Tissue informative cell-free DNA methylation sites in amyotrophic lateral sclerosis
C. Caggiano,
M. Morselli,
X. Qian
et al.
Abstract:Cell-free DNA (cfDNA) is increasingly recognized as a promising biomarker candidate for disease monitoring. However, its utility in neurodegenerative diseases, like amyotrophic lateral sclerosis (ALS), remains underexplored. Existing biomarker discovery approaches are tailored to a specific disease context or are too expensive to be clinically practical. Here, we address these challenges through a new approach combining advances in molecular and computational technologies. First, we develop statistical tools t… Show more
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