Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling
Hella Luksch,
Felix Schulze,
David Geißler-Lösch
et al.
Abstract:Constitutive activation of STING by gain-of-function mutations triggers manifestation of the systemic autoinflammatory disease STING-associated vasculopathy with onset in infancy (SAVI). In order to investigate the role of signaling by tumor necrosis factor (TNF) in SAVI, we used pharmacological inhibition and genetic inactivation of TNF receptors 1 and 2 in murine SAVI, which is characterized by T cell lymphopenia, inflammatory lung disease and neurodegeneration. Pharmacologic inhibition of TNF signaling impr… Show more
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