Tissue <i>N-</i>linked glycosylation as potential prognostic biomarker for biochemical recurrence-free survival

Vermassen, Tijl; Broeck, Arne Van Den; Lumen, Nicolaas; Callewaert, Nico; Rottey, Sylvie; Delanghe, Joris

doi:10.1080/1354750x.2021.1891290

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…Secondly, in the RP cohort, both the 2AFc/2T and 2AFc/MA ratios showed prognostic properties in relation to EFS. The observation for the latter ratio is in concordance with the findings for tissue N-glycosylation, in which the 2AFc/MA ratio, among other N-glycan patterns, was significantly associated with BCR-free survival in PCa patients undergoing RP [22]. On the other hand, in the EBRT cohort, only the overall Fc/MA ratio showed a trend toward significant association to EFS.…”

Section: Discussionsupporting

confidence: 89%

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The Association between Urine N-Glycome and Prognosis after Initial Therapy for Primary Prostate Cancer

Vermassen,

Lumen,

Van Praet

et al. 2024

Biomedicines

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Next to prostate-specific antigen, no biochemical biomarkers have been implemented to guide patient follow-up after primary therapy for localized prostate cancer (PCa). We evaluated the prognostic potential of urine N-glycome in terms of event-free survival (EFS) in patients undergoing primary therapy for PCa. The prognostic features of the urine N-glycosylation profile at diagnosis, assessed in 77 PCa patients, were determined in terms of EFS next to standard clinical parameters. The majority of patients were diagnosed with International Society of Urological Pathology grade ≤ 3 (82%) T1–2 tumors (79%) and without pelvic lymph node invasion (96%). The patients underwent active surveillance (14%), robot-assisted laparoscopic prostatectomy (48%), or external beam radiotherapy (37%). Decreased ratios of biantennary core-fucosylation were noted in patients who developed an event, which was linked to a shorter EFS in both the intention-to-treat cohort and all subcohort analyses. Combining the urine N-glycan biomarker with the D’Amico Risk Classification for PCa resulted in an improved nomogram for patient classification after primary therapy. The rate of urine N-glycan biantennary core-fucosylation, typically linked to more aggressive disease status, is lower in patients who eventually developed an event following primary therapy and subsequently in patients with a worse EFS. The combination of urine N-glycan biomarkers together with clinical parameters could, therefore, improve the post-therapy follow-up of patients with PCa.

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Section: Discussionsupporting

confidence: 89%

“…Our research group has previously demonstrated that aberrations in the N-glycome show tremendous potential as diagnostic and prognostic biomarkers in PCa [21][22][23][24]. However, no data exist on the prognostic properties of urine N-glycans following primary PCa therapy.…”

Section: Introductionmentioning

confidence: 99%

The Association between Urine N-Glycome and Prognosis after Initial Therapy for Primary Prostate Cancer

Vermassen,

Lumen,

Van Praet

et al. 2024

Biomedicines

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“…This can also be the case here, as we noticed that a high vibrational state at 5236 cm −1 is associated with an improved prognosis. This can be associated with the fact that a higher amount of fucosylated triantennary structures, as indicated in previous research from our group, is also associated with a prolonged BCR-FS [ 31 ]. Furthermore, the comparison for the second derivative of the NIR spectra between patients with and without BCR also revealed several spectral bands of interest (n = 8), of which most can be linked to changes observed in glycans.…”

Section: Discussionsupporting

confidence: 57%

“…Here, in contrast to the observation at 5236 cm −1 , a high vibrational state at 5956 cm −1 was associated with a poor prognosis. This association may be explained by the fact that the presence of bisecting N-acetylglucosamines is also linked to a shorter BCR-FS [ 31 ]. It is therefore safe to assume that the NIR spectra can detect changes in the glycoprotein content in prostatectomy samples, possibly due to malignant transformation in the PCa specimens.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Features of Near-Infrared Spectroscopy Following Primary Radical Prostatectomy

Vermassen

Himpe

Coopman

et al. 2021

Cancers

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Background: Only a few biomarkers have been evaluated for their prognostic value with regard to biochemical recurrence (BCR) following primary radical prostatectomy. We explored the possibilities of using near-infrared (NIR) spectroscopy as a prognostic biomarker for BCR-free survival (BCR-FS). Methods: Tissue specimens from 82 prostate cancer patients were obtained. Formalin-fixed paraffin-embedded slides (hematoxylin–eosin-stained) were analyzed using NIR spectroscopy. Prognostic features for BCR-FS were determined following normalization of the spectra. Results: Several differences were found throughout the NIR spectrum for the patients with or without BCR, for both the first derivative and second derivative of the NIR spectrum. Following categorization and Cox regression analysis, spectral regions at 5236 cm−1 (first derivative; median BCR-FS not reached versus 3.2 years; HRhigh = 0.18 [0.08–0.39]; and p < 0.0001) and at 5956 cm−1 (second derivative; median BCR-FS not reached versus 3.8 years; HRlow = 0.22 [0.10–0.48]; and p = 0.0002) showed prognostic properties for BCR-FS. The combination of both parameters further increased the prognostic value of NIR (p < 0.0001). Conclusions: We demonstrated NIR spectral variations between patients with or without BCR, which have been shown to have prognostic value. This easy-to-use technique could possibly further improve post-primary radical prostatectomy monitoring and swift referral to adjuvant local therapies. Further elaboration is highly recommended to fully elucidate these variations and to gain a deeper insight into the changing chemical and physical compositions of the prostate tumor architecture.

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How glycomic studies can impact on prostate cancer

Tkac,

Bertok

2023

Expert Review of Proteomics

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Tissue N-linked glycosylation as potential prognostic biomarker for biochemical recurrence-free survival

Cited by 3 publications

References 39 publications

The Association between Urine N-Glycome and Prognosis after Initial Therapy for Primary Prostate Cancer

The Association between Urine N-Glycome and Prognosis after Initial Therapy for Primary Prostate Cancer

Prognostic Features of Near-Infrared Spectroscopy Following Primary Radical Prostatectomy

How glycomic studies can impact on prostate cancer

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