Tissue Hormones

Labhart, A.

doi:10.1007/978-3-642-96158-8_15

Cited by 1 publication

(2 citation statements)

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“…This approximately 3-fold enhancement occurred at concentrations slightly above those encountered physiologically (Labhart, 1986) but could approximate the ranges of concentrations encountered in the therapy of neoplastic diseases with SMS analogs (Kutz et al, 1986). It is of interest that cytotoxic activity is statistically significantly increased over a very narrow range of concentrations not including the highest concc;.…”

Section: Discussionmentioning

confidence: 85%

“…Since SMS does inhibit the secretion of other peptides (Brazeau et al, 1973;McCann et al, 1980) including those of the immune system (Yousefi et al, 1990), it might be anticipated that it would also decrease the secretion of cytotoxic cytokines. This inhibition occurs in ranges that are above those encountered in the circulation (Labhart, 1986). However, such levels of SMS could possibly be found in areas proximate to the cells secreting SMS (paracrine effect).…”

Section: Discussionmentioning

confidence: 98%

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The paradoxical effects of somatostatin on the bioactivity and production of cytotoxins derived from human peripheral blood mononuclear cells

Yousefi

Vaziri²,

Carandang³

et al. 1991

Br J Cancer

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Summary Somatostatin (SMS), a naturally occurring peptide is known to inhibit the production of certain protein molecules and to diminish the ability of peripheral blood mononuclear cells to proliferate. We tested the effects of three forms of SMS on the bioactivity of both lymphotoxin (LT) and tumour necrosis factor (TNF). We also tested the effects of these agents on production of cytotoxins by peripheral blood mononuclear cells. We found the 28 amino acid form of SMS significantly enhanced the bioactivity of both LT and TNF (10-9 M concentration) when tested in mouse L cells. The 14 amino acid form of SMS enhanced LT (10-9 M concentration) activity but not TNF activity. The first 14 amino acid form of SMS-28 (amino terminal) did not affect bioactivity of the cytotoxin. In contrast, the naturally occurring 14 amino acid form of SMS (10-8 M concentration) significantly diminished production of cytotoxin by human peripheral blood mononuclear cells. Cytotoxin produced by the latter was shown to be a combination of both LT and TNF.

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Section: Discussionmentioning

confidence: 85%