Tissue histamine levels in male and female normal and nude mice

Abstract

In comparison with those in normal (+/+) mice, tissue histamine levels were lower in athymic (nu/nu) female mice and higher in athymic male mice. The sexual difference was less marked or absent in nu/nu mice. These results show (a) that endocrine factors are involved in the distribution of tissue histamine, and (b) that the thymus cannot be considered as the main source of tissue histamine in pathogen-free mice.

Tissue histamine levels in male and female mast cell deficient mice (W/Wv) and in their littermates (Wv/+, W/+ and +/+)

“…Histological study of the ovaries and testes of normal and genetically sterile animals collected 0 to 28 days postnatal has demonstrated that the few ova and spermatogonia found in gonads of W/W v mice develop more slowly than do the much larger numbers in the gonads of normal littermates [17]. The absence of sexual difference in tissue histamine levels of W/W v mice is in accordance with results obtained in nude mice which present endocrine disturbances [18]. Moreover, in normal mice, after ovariectomy, tissue histamine levels decreased while they increased after castration of males [19].…”

Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c

“…Very high concentrations of histamine in the stomach had been detected already previously [14,15]. However, in these latter studies, the values found were about twice as high as those found in the present study.…”

<b>THE SEROTONIN CONTENT AND TRYPTOPHAN 5-MONOOXYGENASE ACTIVITY IN THE STOMACH OF AN ATHYMIC NUDE MOUSE AND MAST CELL-DEEICIENT </b><b>MOUSE </b>

“…In the skin of this mouse, the histamine concentration and the number of mast cells were also reported to be increased (histamine: 1.7-fold; number of cells: 3-4-fold) (3,8,19), but the increases were not as great as that in SHT observed in this study. In an athymic rat (rnu/rnu), the number of mast cells in the subepidermis but not in the deep dermis was reported to be increased compared with the control rat (1).…”

“…The inability of the thymus-deficient nude mouse to accumulate mucosal mast cells in response to a nematode infection also suggested the dependency of mucosal mast cells on the thymus (14). In other studies, however, the differentiation was demonstrated to be independent of the thymus or T cells (3,9,11). It was also reported that the thymus suppresses the dif- €¢Z"I|l_q:,< §,?t" ' "' €- §:-555!…”