Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism

Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model

“…In addition, other studies conducted autologous bone marrow stem cells transplantation with platelet-rich plasma to treat BRONJ in patients [46,47]. However, animal studies have indicated that MSCs frequently congregate within the pulmonary circulation after I.V [29]. In addition, clinical MSCs I.V.…”

“…of allogeneic multipotent mesenchymal stromal cells (MSCs) is effective for bone exposure in BRONJ-like animal models [25,26]. However, injected MSCs at the diseased area are relatively unstable [27]; thus, cells that do not engraft circulate throughout the body, resulting in pulmonary embolism and even death in some clinical cases and animal studies [28,29].…”

Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model

“…Previous studies documented two contrary opinions about the relationship between stem cell therapy and APTE. Some clinical studies and animal experimental studies indicated that intravenous administration of stem cells facilitated PTE development [8][9][10]27], while others implied transplantation of stem cells may be a therapeutic option for treating solitary deep venous thrombosis [6,11,12]. However, so far there has been no study investigating the function of BMSCs on established or existed PTEs which containing multiple thrombi, nor the gender difference of therapeutic efficacy of BMSCs on APTE.…”

“…Several clinical studies indicated that the intravascular administration of stem cells may increase the risk for developing PTE [8,9]. A recent investigation in a mouse model indicated significant procoagulation and resulting PTE after stem cell administration [10]. However, there are also studies indicating that stem cells could facilitate thrombus resolution [11][12][13].…”

Autologous fat is an efficient hemostatic agent in perforator flap surgery

“…TF localized to the cell surface of adipose-derived mesenchymal stem cells triggers the coagulation cascade. 4 The adipose tissue microenvironment is also prone to increased local fibrin deposition through TF up regulation. 5 The use of autologous fat as a haemostatic agent in perforator flap surgery has not been described before.…”