Tissue Factor and Tissue Factor Pathway Inhibitor in Men and Women Affected with Hypertension

Abstract

Hypertension is one of the most common chronic diseases characterized with continuous elevation of blood pressure. The present study involved tested 45 hypertensive men and 45 hypertensive women. Sixty (60) apparently healthy subjects (30 men and 30 women) were also included to serve as a control group. All men and women were subdivided into three groups according to their ages (41-50, 51-60, 61-70 years old).Results yield from present study indicated a significant decrease (p<0.05) in the levels of testosterone and estradiol in first age group of hypertensive men and women respectively and there were nonsignificant differences (p>0.05) in second and third age groups of patients compared to healthy groups.A significant progressive increase (p<0.05) in the levels of tissue factor (TF) in all groups of hypertensive men and women compared to healthy groups. In contrast, values of tissue factor pathway inhibitor (TFPI) confirmed a significant lowering (p<0.05) in all age groups of hypertensive men and women when compared with those healthy subjects. In conclusion, data obtained from this study can be attributed to damage of vascular system resulted from continuous increase blood pressure, drop of sexual hormones, and aging