Tissue Factor and COVID-19 Associated Thrombosis

Abstract

Microbial infections activate the innate and adaptive immune systems. 1 Pathogen-associated molecular patterns produced by microbes, such as double-stranded RNA, are detected by PRRs (pattern-recognition receptors), such as toll-like receptor 3, and this leads to the expression of interferons and cytokines. 1 , 2

Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19

“…Several studies have found that circulating TF is increased in patients with COVID-19, but the mechanisms underlying this upregulation and how it contributes to COVID-19 clinical manifestations remains unknown. [10][11][12][13] Because of the associations between inflammation and thrombosis in COVID-19, we hypothesized that activated monocytes themselves could orchestrate both inflammation and thrombosis associated with SARS-CoV-2 infections. In this study, we used systems biology approaches, including targeted proteomics, transcriptomics, and mass cytometry (cytometry by time of flight [CyTOF]), to define circulating inflammatory/vascular mediators and the immune phenotypes of circulating immune cells from subjects with COVID-19.…”