Tissue Engineering von Herzklappen

Abstract

With the introduction of heart valve prostheses cardiac valvular disease has become much more accessible to therapeutic options. However, currently available prostheses display significant limitations, such as limited long-term durability (biological prostheses) and a long-term necessity for anticoagulation therapy. Hence, alternative prosthesis types have been extensively explored in recent years particularly aiming at the development of vital and regenerative prostheses by means of tissue engineering. In the scientific field, different competing concepts have been introduced, including biological or synthetic scaffolds which can be further enhanced by cellular or extracellular components to promote further in vivo development of the prosthesis after implantation. Nowadays, decellularized donor heart valves are among the most advanced prosthesis types experiencing growing clinical attention and widespread use.

Kardiovaskuläres Tissue-Engineering

“…Für die meisten Patienten kommt lediglich ein prothetischer Klappenersatz mit den entsprechenden Nachteilen in Betracht. Die "ideale" Klappenprothese sollte folgende Anforderungen erfüllen [4,5]:…”

The Effect of Rolling and Crimping on Cell-Seeded Synthetic Scaffolds for the Development of Transcatheter Valves by Tissue Engineering

“…Tissue-engineered synthetic heart valves have been in research for some time past (Akhyari et al, 2011;Vacanti, 2006) and minimal invasive valve replacement has been in the ascendant recently (Higgins et al, 2011;Raja & Navaratnarajah, 2009). Combining tissue-engineering and minimal-invasive methods in heart surgery would be a new milestone in therapy of valvular disease.…”

Supremacy of modern morphometry in typing renal oncocytoma and malignant look-alikes

“…As it is now possible to test several marker proteins simultaneously, immunohistochemical tumour characterization has shifted from the hunt for a single typespecific protein to the employment of a marker spectrum (Zitzelsberger et al 1994). Keeping in line with the markerbased approach, the differential diagnosis of RO versus CCRCC versus ChRCC uses several adjunct stains such as Hale's colloidal iron (Tickoo et al 1998), cytokeratin 7 (Adley et al 2006) and CD117 (Akhyari et al 2011). However, these methods are expensive and may eschew standardization, putting reproducibility at risk, and may cause interpretation flaws due to a limited sensitivity and specificity (Fischer et al 2007).…”