Tissue Engineering the Annulus Fibrosus Using 3D Rings of Electrospun PCL:PLLA Angle-Ply Nanofiber Sheets

Shamsah, Alyah H; Cartmell, Sarah H.; Richardson, Stephen M.; Bosworth, Lucy A.

doi:10.3389/fbioe.2019.00437

Cited by 30 publications

(34 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NP demands most TE strategies to employ the use of hydrogels as they are hydrophilic [ 361 ]. Conversely, biomaterials’ research for AF TE targets rather fibrous organized constructs, often achieved through electrospinning [ 362 , 363 ]. However, the natural complexity of the AF structure and composition is uniquely designed to resist an amazing variety of mechanical loads, both in nature and magnitude, which makes AF TE particularly challenging [ 363 , 364 ].…”

Section: Ivd Regeneration Strategies: Biological Targets and Biomamentioning

confidence: 99%

Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research

Baumgartner

Wuertz‐Kozak

Maitre

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a progressive loss of the IVD structure and functionality, leading to severe impairments with restricted treatment options due to the highly demanding mechanical exposure of the IVD. Degenerative changes in the IVD usually increase with age but at an accelerated rate in some individuals. To understand the initiation and progression of this disease, it is crucial to identify key top-down and bottom-up regulations’ processes, across the cell, tissue, and organ levels, in health and disease. Owing to unremitting investigation of experimental research, the comprehension of detailed cell signaling pathways and their effect on matrix turnover significantly rose. Likewise, in silico research substantially contributed to a holistic understanding of spatiotemporal effects and complex, multifactorial interactions within the IVD. Together with important achievements in the research of biomaterials, manifold promising approaches for regenerative treatment options were presented over the last years. This review provides an integrative analysis of the current knowledge about (1) the multiscale function and regulation of the IVD in health and disease, (2) the possible regenerative strategies, and (3) the in silico models that shall eventually support the development of advanced therapies.

show abstract

Section: Ivd Regeneration Strategies: Biological Targets and Biomamentioning

confidence: 99%

Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research

Baumgartner

Wuertz‐Kozak

Maitre

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Regeneration of annulus fibrosus (AF) tissue to alleviate chronic lower back pain was carried out by using a bilayer scaffold prepared from synthetic biopolymer blend of poly(ε-caprolactone) and poly(L-lactic acid). These electrospun fiber scaffolds mimicked the AF tissue and supported cell viability and orientation, secretion of collagen, and desirable tensile properties [93]. Nanaki et al reported the fabrication of risperidone controlled release microspheres as long-acting injectable formulations.…”

Section: Poly(lactic Acid) Plamentioning

confidence: 99%

Development of Hybrid Materials Based on Polymers for Biomedical Applications: A Short Introduction

Miguel

2021

Materials Research Foundations

View full text Add to dashboard Cite

This chapter is focused on some of the most important polymers used for preparing hybrid materials applied in biomedicine. The work is divided into two parts: Non-degradable polymers used for hybrid materials in implants and degradable polymers employed to fabricate biomedical implants and devices. Each part describes the main characteristics of these structures, followed by a list of the most significant polymers and derivatives. This brief introduction could be useful for industry, students, or people interested in the recent advances of biomedical applications where polymers play an important role.

show abstract

“…This technique is based on seeding cells directly onto a scaffold, whose biocompatible structure will allow the cells to adhere and grow. The seeding can be static or dynamic through the use of a rotational systems ( Villalona et al, 2010 ; Shamsah et al, 2020 ) but in every case, the scaffolds are immersed in different solutions containing the cells of interest until these latter adhere to the scaffold.…”

Section: Biofabrication Techniquesmentioning

confidence: 99%

Vascular Tissue Engineering: Challenges and Requirements for an Ideal Large Scale Blood Vessel

Devillard

Marquette

2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Since the emergence of regenerative medicine and tissue engineering more than half a century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (>1 cm3) to meet the clinical needs of viable tissue grafts but also for biological research applications. Considerable advancements in biofabrication have been made since Weinberg and Bell, in 1986, created the first blood vessel from collagen, endothelial cells, smooth muscle cells and fibroblasts. The synergistic combination of advances in fabrication methods, availability of cell source, biomaterials formulation and vascular tissue development, promises new strategies for the creation of autologous blood vessels, recapitulating biological functions, structural functions, but also the mechanical functions of a native blood vessel. In this review, the main technological advancements in bio-fabrication are discussed with a particular highlights on 3D bioprinting technologies. The choice of the main biomaterials and cell sources, the use of dynamic maturation systems such as bioreactors and the associated clinical trials will be detailed. The remaining challenges in this complex engineering field will finally be discussed.

show abstract

Tissue Engineering the Annulus Fibrosus Using 3D Rings of Electrospun PCL:PLLA Angle-Ply Nanofiber Sheets

Cited by 30 publications

References 38 publications

Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research

Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research

Development of Hybrid Materials Based on Polymers for Biomedical Applications: A Short Introduction

Vascular Tissue Engineering: Challenges and Requirements for an Ideal Large Scale Blood Vessel

Contact Info

Product

Resources

About