Tissue Engineering Scaffolds for Repairing Soft Tissues

Lantada, Andrés Díaz; Mayola, Enrique Colomer; Deschamps, Sébastien; Sánchez, Beatriz Pareja; Ruiz, Josefa Predestinación García; Iniesta, Hernán Alarcón

doi:10.1007/978-3-319-29328-8_18

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…A common process for generating porous structures involves a pore generator, called porogen. These porous PDMS materials can be prepared using sugar, salt, self‐assembled colloidal microspheres, suspension polymerization, emulsion droplets, and CO 2 gas generated by NaHCO 3 as templates, among which the sacrificial sugar template technique has been the most popular because of its simple steps, cost effectiveness, and ecofriendliness . Recently, porous PDMS materials have been successfully synthesized for selective oil absorption from water.…”

Section: Introductionmentioning

confidence: 99%

Preparation and morphology control of three‐dimensional interconnected microporous PDMS for oil sorption

Wang

Zhao

et al. 2015

Polymers for Advanced Techs

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This study described an approach to impart controlled morphology and improved pore interconnectivity to poly(dimethylsiloxane) (PDMS) sponges for oil sorption by partially fusing the sugar particles together prior to creation of a continuous PDMS matrix. PDMS sponges with high absorption capacity, low water pickup, and remarkable reusability were fabricated by the polymerization of the PDMS prepolymer and a curing agent in cyclohexane. The PDMS sponge showed oil absorbency in the range from 790% to 4000% for various oils solvents, with the maximum absorption capacity reaching up to 23 times of its weight. Compressive modulus of PDMS subjected to sugar fusion for 24 hr was significantly increased to 1900 Mpa. The sponge also exhibited excellent repellency to corrosive strong acid and alkali. Besides, oil can be quickly adsorbed in tens of seconds and maintained for several months. Furthermore, PDMS sponges showed little loss of their absorption capacities and owned weights after 20 absorbing/recovering cycles. Copyright © 2015 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Preparation and morphology control of three‐dimensional interconnected microporous PDMS for oil sorption

Wang

Zhao

et al. 2015

Polymers for Advanced Techs

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“…4 The use of these mixtures of soluble factors, extracellular proteoglycans and collagen produced by hMSCs, known as conditioned medium (CM-hMSCs), has been shown to be effective in forming a bio-interface that increases the adhesion of hMSCs, [5][6][7][8] including sponge structures of PDMS. 9 The concept of a scaffold has changed from being considered an inert material to being a proactive cell-instructive material able to control and guide morphogenesis and tissue repair, by displaying the biochemical and biophysical processes needed for tissue formation, maintenance and function. It is known that changes in material properties such as hydrophobicity, surface charge, roughness and stiffness are important for cell-response.…”

Section: Introductionmentioning

confidence: 99%

Conditioned bio-interfaces of silicon/porous silicon micro-patterns lead to the chondrogenesis of hMSCs

et al. 2015

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aThe interaction between cells and materials is of scientific and technological interest for the development of new biomaterials with improved functional properties. In this work the chondrogenesis (CG) of human mesenchymal stem cells (hMSCs) derived from the bone marrow of healthy donors has been achieved on Si/PSi surfaces after pre-treatment with a conditioned medium derived from hMSCs (CM). The chondrogenic process was analyzed in fixed-cell preparations by immune fluorescence, determining the cellular localization of b-catenin and the transcription factors STAT-5, Runx2 and vitamin D receptor (VDR). In a week of CG on Si/PSi or CM-Si/PSi, b-catenin showed cell-cell contacts priming a preferential chondrogenic process on a PSi surface, in contrast with the preferential proliferation and migration processes observed on hexagonal/triangular micro-designed Si areas. Interestingly, the presence of a CM bio-interface improves this differentiation process with respect to a control PSi surface. The chondroinductive effect was also observed in STAT-5, which was highly expressed and is involved in intracellular signaling of many differentiation receptors related to development and tissue repair. In good agreement with the above results, the co-localization of transcription factors Runx2/VDR at nuclei supports active transcription of chondrogenic genes. Considering these observations, we propose that the combination of a rough PSi surface and the components of the CM-hMSCs biointerface boosts the chondrogenesis of hMSCs. These findings suggest that the tailoring of Si/PSi scaffolds with appropriate bio-interface combinations improves their therapeutic potential.

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Tissue Engineering Scaffolds for Repairing Soft Tissues

Cited by 2 publications

References 43 publications

Preparation and morphology control of three‐dimensional interconnected microporous PDMS for oil sorption

Preparation and morphology control of three‐dimensional interconnected microporous PDMS for oil sorption

Conditioned bio-interfaces of silicon/porous silicon micro-patterns lead to the chondrogenesis of hMSCs

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