Tissue Engineering of the Meniscus

Buma, P.; Meel, Marloes van; Tienen, T.G. van; Veth, R.P.H.

doi:10.1007/978-1-59745-239-7_16

Cited by 5 publications

(7 citation statements)

References 106 publications

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“…Over the last two decades, a number of tissue engineering strategies have emerged to replace all or part of the meniscus, with the objective of improving immediate and longterm patient outcomes [6]. Cells are an important component in tissue engineering, and should facilitate regeneration of injured meniscus through proliferation, as well as synthesis of appropriate extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

Osteoarthritis Prevention Through Meniscal Regeneration Induced by Intra-Articular Injection of Meniscus Stem Cells

Shen

Chen

Zhu

et al. 2013

Stem Cells and Development

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Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain in the short-term but often leads to osteoarthritis (OA) in the long-term. Here, this study aimed to identify and characterize a novel population of meniscus-derived stem cells (MeSCs) and develop a new strategy of articular cartilage protection by intra-articular injection of these cells. The ''stemness'' and immune properties of MeSCs were investigated in vitro, while the efficacy of intra-articular injection of MeSCs for meniscus regeneration and OA prevention were investigated in vivo at 4, 8, and 12 weeks postsurgery. MeSCs displayed typical stem cell characteristics such as low immunogenicity and even possessed immunosuppressive function. In a rabbit meniscus injury model, transplantation of allogenous MeSCs did not elicit immunological rejection, but promoted neo-tissue formation with better-defined shape and more matured extracellular matrix. In a rabbit experimental OA model, transplantation of MeSCs further protected joint surface cartilage and maintained joint space at 12 weeks postsurgery, whereas extensive joint surface irregularities and joint space stenosis were observed in the control group. This study thus evoked a new strategy for articular cartilage protection and meniscus regeneration by intra-articular injection of MeSCs for patients undergoing meniscectomy.

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Section: Introductionmentioning

confidence: 99%

Osteoarthritis Prevention Through Meniscal Regeneration Induced by Intra-Articular Injection of Meniscus Stem Cells

Shen

Chen

Zhu

et al. 2013

Stem Cells and Development

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“…Thus, the permeability was maintained constant to the value estimated in Table 2 for the other simulations. Furthermore, it has been shown that the more porous is a scaffold structure, the rougher is the surface, which ultimately results in poor frictional properties [2]. Although this might be a critical issue for the proper biomechanical function of the anatomical scaffolds, the surface of the fibers comprising the specific scaffolds treated in this study are rather smooth despite any variation in porosity.…”

Section: Maximal Fibril Strainmentioning

confidence: 88%

“…Their main functions are to provide stability to the joint, to absorb mechanical shocks, and to assist in the lubrication and in the nutrient supply of the over-and under-lying articular cartilaginous plateaus through the synovial fluid [1,2]. Only about 20% of the meniscus is supplied with blood in the periphery where it joins to the vascular knee lining [1,3].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, alternative methods to restore the joint articulation while keeping menisci functionality are needed. A possible alternative to meniscal removal is the implantation of a tissue engineered meniscus, which might result in the restoration of the original tissue functionalities [2,[10][11][12]. This tissue engineered construct typically consists of a temporal template -a scaffold -where cells are seeded and can migrate to homogeneously form the desired tissue through the production of extra cellular matrix [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering

Moroni¹,

Lambers²,

Wilson³

et al. 2007

TOBEJ

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Solid Free-Form Fabrication (SFF) technologies allow the fabrication of anatomical 3D scaffolds from computer tomography (CT) or magnetic resonance imaging (MRI) patients' dataset. These structures can be designed and fabricated with a variable, interconnected and accessible porous network, resulting in modulable mechanical properties, permeability, and architecture that can be tailored to mimic a specific tissue to replace or regenerate. In this study, we evaluated whether anatomical meniscal 3D scaffolds with matching mechanical properties and architecture are beneficial for meniscus replacement as compared to meniscectomy. After acquiring CT and MRI of porcine menisci, 3D fiber-deposited (3DF) scaffolds were fabricated with different architectures by varying the deposition pattern of the fibers comprising the final structure. The mechanical behaviour of 3DF scaffolds with different architectures and of porcine menisci was measured by static and dynamic mechanical analysis and the effect of these tissue engineering templates on articular cartilage was assessed by finite element analysis (FEA) and compared to healthy conditions or to meniscectomy. Results show that 3DF anatomical menisci scaffolds can be fabricated with pore different architectures and with mechanical properties matching those of natural menisci. FEA predicted a beneficial effect of meniscus replacement with 3D scaffolds in different mechanical loading conditions as compared to meniscectomy. No influence of the internal scaffold architecture was found on articular cartilage damage. Although FEA predictions should be further confirmed by in vitro and in vivo experiments, this study highlights meniscus replacement by SFF anatomical scaffolds as a potential alternative to meniscectomy.

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“…The most common available clinical treatment for meniscus tear is partial meniscectomy. However, this treatment only resolves the short-term clinical problem and in the longer-term, it will still lead to cartilage degradation, increase in pain as well as the loss of joint function [3].…”

Section: Introductionmentioning

confidence: 99%

Decellularized bovine meniscus in morphological assessment prior to bioscaffold preparation

Norzarini¹,

Azhim²,

Ushida

2015

2015 10th Asian Control Conference (ASCC)

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Tissue Engineering of the Meniscus

Cited by 5 publications

References 106 publications

Osteoarthritis Prevention Through Meniscal Regeneration Induced by Intra-Articular Injection of Meniscus Stem Cells

Osteoarthritis Prevention Through Meniscal Regeneration Induced by Intra-Articular Injection of Meniscus Stem Cells

Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering

Decellularized bovine meniscus in morphological assessment prior to bioscaffold preparation

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