Tissue engineering for female reproductive organs

Magalhaes, Renata S.; Williams, J. Koudy; Atala, Anthony

doi:10.1016/b978-0-12-818422-6.00049-6

Cited by 2 publications

(2 citation statements)

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“…While surgical and non-surgical treatment options are available for treating vaginal defects, the low efficacy and long-term complications of these treatments necessitate developing alternative treatment options [7,8]. For example, repeated vaginal dilation is not convenient for the patients, and the surgical development of neovagina using tissue grafting is challenged by the unavailability of suitable donor tissues, graft failure, and the need for additional surgery for graft harvesting [9,10].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

et al. 2023

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Congenital vaginal anomalies and pelvic organ prolapse affect different age groups of women and both have significant negative impacts on patients’ psychological well-being and quality of life. While surgical and non-surgical treatments are available for vaginal defects, their efficacy is limited, and they often result in long-term complications. Therefore, alternative treatment options are urgently needed. Fortunately, tissue-engineered scaffolds are promising new treatment modalities that provide an extracellular matrix (ECM)-like environment for vaginal cells to adhere, secrete ECM, and be remodeled by host cells. To this end, ECM-based scaffolds or the constructs that resemble ECM, generated by self-assembly, decellularization, or electrospinning techniques, have gained attention from both clinicians and researchers. These biomimetic scaffolds are highly similar to the native vaginal ECM and have great potential for clinical translation. This review article aims to discuss recent applications, challenges, and future perspectives of these scaffolds in vaginal reconstruction or repair strategies.

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Section: Introductionmentioning

confidence: 99%

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

et al. 2023

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“…Scientific researchers have recently expanded their research involving stem cells to offer the opportunity to treat gynecological pathologies such as pelvic floor prolapse and uterine and vaginal reconstruction. New techniques and ideas from different fields are leading to surgical procedures innovations and these available therapies involve biological substitutes that can provide a favourable microenvironment for cells and tissues to grow and restore biological activities (Magalhaes et al, 2020 ). In this vein, considering the advances in scientific experiments, the tissue engineering may offer new therapies for vaginal reconstruction as well as congenital agenesis by combining cell therapy and new technologies to create new tissue.…”

Section: Introductionmentioning

confidence: 99%

Scaffold strategies combined with mesenchymal stem cells in vaginal construction: a review

et al. 2021

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Tissue engineering has provided new treatment alternatives for tissue reconstruction. Advances in the tissue engineering field have resulted in mechanical support and biological substitutes to restore, maintain or improve tissue/organs structures and functions. The application of tissue engineering technology in the vaginal reconstruction treatment can not only provide mechanical requirements, but also offer tissue repairing as an alternative to traditional approaches. In this review, we discuss recent advances in cell-based therapy in combination with scaffolds strategies that can potentially be adopted for gynaecological transplantation.

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Tissue engineering for female reproductive organs

Cited by 2 publications

References 84 publications

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

Scaffold strategies combined with mesenchymal stem cells in vaginal construction: a review

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