Tissue engineering: applications for maxillofacial surgery

Sumi, Yukio; Mizuno, Hirokazu; Honda, Masaki; Oda, Tetsuya; Wada, Keisuke; Boo, Jae Seong; Hata, Ken‐ichiro

doi:10.1016/s0928-4931(00)00170-3

Cited by 11 publications

(5 citation statements)

References 7 publications

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“…The medical applications of carbon nanotubes are determined by the following properties: biocompatibility in contact with blood, bone, cartilage and soft tissues; biofunctionality understood as the ability of taking over certain functions of tissues by a mutual adjustment of implants and tissues properties [276][277][278].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Contreras-García¹,

Bucio²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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By definition, nanomaterials are multifunctional due to the co-incorporation of both therapeutic and bioimaging agents. Among the therapeutic applications of the polymeric nanomaterials are found drug, protein or gene delivery, tissue engineering. Other advances in bioapplications include cell-labeling, cell membrane modeling, agent delivery and targeting. Additionally, imaging nanobiotechnology is applied to sensorization and diagnosis with biosensors and biomarkers for biodetection and bioimaging, respectively. In this chapter are described the different polymeric nanostructures applied to therapy and diagnosis such as polymeric-based core-shell colloid, proteins and peptides, drug conjugates and complexes with synthetic polymers, dendrimers, vesicles, micelles, carbon nanotubes, biopolymers, smart nano polymers, metal-polymer complexes, enzyme-responsive nanoparticles, and hybrid polymeric nanomaterials. The different types of polymers are fabricated using several approaches ranging from conventional chemical methods to more sophisticated processes such as surface modification using ionizing radiation to obtain layers free of pollutants without purification and isolation processes among other advantages.

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Section: Carbon Nanotubesmentioning

confidence: 99%

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Contreras-García¹,

Bucio²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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“…28 Çalışmanın sonucunda, TCP ile MKH'nin birlikte uygulandığı deney grubunda lamellar yapıya sahip yeni kemik oluştuğu gözlenmiştir. Bunun yanında Ueda ve ark., fibuladan MKH izolasyonunu kolay olması nedeniyle tercih ettiklerini belirtirken, bu çalışmada, kemik iliği, tavşanın tibiasından ayrıştırılmıştır.…”

Section: S Sk Ko or Runclassified

“…30 Buna ilave olarak, Ueda ve ark., sinüs tabanını kaldırdıklarından, yeni kemiğin oluşabilmesi için kavite şeklinde bir boş alan elde etmişler ve böylece bariyer olarak membran kullanılabilmiş ve yönlen-dirilmiş doku rejenerasyonu uygulayabilmişlerdir. 28 Çalışmamızda ise kemik yüzeyi düz bir hat halinde olduğundan, titanyum kapsüller ile bariyer oluş-turmak zorunda kalınmıştır. Ayrıca, kök hücrelerin kemik yüzeyinde tutunmaları güç olduğundan, MKH'ler kapsül içindeki kollajene emdirilerek yerleştirilmiştir.…”

Section: S Sk Ko or Runclassified

Histologic Evaluation of the New Bone Obtained from Directed Bone Enhancement with Mesenchymal Stem Cell Transplatation in Rabbit Calvarium

Ulukaradağ¹,

Aydıntuğ²,

Günhan³

et al. 2012

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Çene yüz bölgesinde oluşan kemik yetersizliklerinin yeniden yapılanmasında birçok tedavi yöntemi mevcuttur. Bu yöntemlerin birçok avantaj ve dezavantajları bulunmaktadır. Gü-nümüzde çene kemiğinin yeniden yapılandırılmasına yönelik çalışmalar kök hücre üzerine yoğunlaşmıştır. Bu çalışmada, mezenşimal kök hücre (MKH) uygulamasının yönlendirilmiş kemik yükseltilmesinde yeni kemik oluşumu üzerindeki etkisini değerlendirmeyi amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma 7 adet Yeni Zelanda tavşanı üzerinde gerçekleştirilmiştir. Çalışma grubunun dışındaki bir tavşanın tibia kemik iliğinden ayrıştırılan MKH'ler, in vitro olarak çoğaltıldıktan sonra, deneyde kullanılan tavşanların kalvaryumlarına kollajen taşıyıcı ile nakledilmiştir. MKH'nin dokuda dağılmaması ve kemik dışındaki dokulardan ayrıştırılabilmesi için titanyum kapsüller kullanılmıştır. Çalışma dört deney grubu içerecek şekilde planlanmış, her tavşana dörder adet titanyum kapsül uygulanmıştır. A ve B gruplarında kemik yüzeyine dekortikasyon yapılmış, A ve C gruplarında MKH uygulanmıştır. D grubunda ise ne dekortikasyon ne de MKH uygulaması yapıl-mıştır. Oluşan yeni kemik miktarı altı skor derecesiyle ve histopatolojik olarak değerlendirilmiş-tir. B Bu ul lg gu ul la ar r: : İstatistiksel olarak, gruplar arasında kemik oluşumu açısından anlamlı bir farklılık elde edilmemiş, ancak grup A'da grup D'ye göre istatistiksel olarak anlamlı ölçüde fazla yeni kemik dokusu oluşumu saptanmıştır. S So on nu uç ç: : MKH uygulamaları, yeni kemik dokusu oluşumunu başarılı bir şekilde indüklemekte ve defekte göre üretilecek yönlendirilmiş doku rejenerasyonu kafesleri ile gereksinim duyulan hacim ve şekilde yeni kemik dokusu elde edilmesi mümkün olabilmektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Mezenşimal kök hücreler; alveolar sırtın büyütülmesi; tavşanlar A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Many treatment methods are available for the reconstruction of bone defects of the mandible with a number of advantages and disadvantages. Current studies in mandible reconstructions are focused on stem cells. In this study, we aimed to investigate the effect of mesenchymal stem cell (MSC) procedure on new bone formation in directed bone enhancement. M Ma a--t te er ri ia al l a an nd d M Me et th ho od ds s: : The study was carried out with 7 New Zealand rabbits. Mesenchymal stem cells isolated from the tibial bone of a rabbit not included in the study, were transferred after in vitro proliferation to the calvariums of rabbits included in the experiment using a collagen carrier. Titanium capsules were used in order to prevent dispersion of MSCs in the tissue and to isolate them from tissues other than bones. The study was planned to include four test groups and each rabbit was implanted four titanium capsules. While Groups A and B underwent decortication, MSC were transplanted to Groups A and C. Neither decortication nor MSC was used in Group D. The amount of new bone formation was evaluated wi...

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“…In case of periodontal and peri-implant therapies that, for instance, require an increase in gingivaltissue volume,three-dimensional (3D) culture could help confirm the findings of studies that have used 2D culture techniques [7]. Tissue engineering comprises three essential elements: culture of appropriate cells; a collagen-, bone-, or synthetic-polymer-based matrix; and addition of soluble mediators containing growth factors and adhesins [8]; the matrices must exhibit structural integrity to form new tissues [9]. These techniques are meant to overcome the limitations of plate-or flask-based cell culture in nutrient cell-culture medium in aspects such as transportation to human receptor sites.…”

Section: Introductionmentioning

confidence: 98%

Review of the biological aspects in the periodontal ligament and alveolar bone associated with compression

2020

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Background: Tissue remodeling requires protein degradation through a process directly dependent on metalloproteinases — enzymes capable of degrading the majority of proteins in this system. This process is regulated by some enzyme inhibitors, and balance between enzyme and inhibitor activity is fundamental to tissue integrity and health. Bone resorption and formation, and the molecules involved in these processes, raise questions on possible differences in tissue behavior in the system. Histological studies of tissues surrounding teeth that have been subjected to such forces show the presence of tension (associated with bone formation) and compression, which induce bone resorption. The duration of load application is an important parameterin osteoclastogenesis. The present study aimed to analyze the biological aspects associated with in vitro compression of the PL and alveolar bone. To this end, we reviewed articles describing the biological events that occur in the PL and alveolar bone during load application on this system and the possible influence of culture medium on the expression of molecules involved in response to such an event. Methods: This literature review included articles published between March 2008 and January 2018 describing in vitro laboratory tests and data on load application and its associated biological events in the human PL and alveolar bone, including studies on molecular-expression events and pathways involved in the process. Conclusions: Intermittent compressive forces stimulate bone resorption in orthodontic treatment, while cyclical forces induce cellular apoptosis at lighter loads than do compressive forces. Both 2D and 3D cell-culture systems seem to reproduce the physiology of evaluated tissues and are reliable analytical models for research purposes.

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Tissue engineering: applications for maxillofacial surgery

Cited by 11 publications

References 7 publications

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Histologic Evaluation of the New Bone Obtained from Directed Bone Enhancement with Mesenchymal Stem Cell Transplatation in Rabbit Calvarium

Review of the biological aspects in the periodontal ligament and alveolar bone associated with compression

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