Tissue Engineering and Regenerative Science in Pediatrics

Stem cells in the trabecular meshwork: Present and future promises

“…Cultured ex vivo , ESCs propagate as a homogeneous, uncommitted cell population for an almost unlimited period of time without losing their pluripotency or stable karyotype (Prelle et al, 2002; Yu and Silva, 2008). ESCs have the greatest differentiation plasticity and the most potential for tumor formation (Prelle et al, 2002; Brevini et al, 2008; Dunn, 2008). Human ESC cells were initially established from embryos (Thomson et al, 1998) and early fetuses (Shamblott and Gearhart, 1998; Prelle et al, 2002).…”

Collagen and heparan sulfate coatings differentially alter cell proliferation and attachmentin vitroandin vivo

“…Newer treatments have attempted to increase intestinal transit time or intestinal length, thereby improving nutrient absorption 8–10 , but have limited regenerative ability. Tissue engineering is an emerging field of biomedical research that aims to regrow or create tissues or organs and may be a viable alternative to current treatments for SBS 11 . Engineered intestine is often limited by expansion of SMCs and the contractile forces they generate 12,13 ; therefore the survival of thick, contractile smooth muscle tissues are essential to the ability to regenerate intestine.…”

Ingeniería tisular y medicina regenerativa en cirugía pediátrica

“…Frente a estas necesidades la Ingeniería Tisular emerge como una alternativa futurística que ha comenzado a tomar vida, desembarcando desde el laboratorio al paciente, logrando en algunos casos la solución frente a problemas de salud, dando origen a la Medicina Regenerativa. En la etapa infantil, producto de la adaptación rápida y óptima en comparación a los adultos, sumado a la necesidad de sustitutos que crezcan con el enfermo, y el seguimiento a largo plazo que brinda la especialidad, es posible advertir que parte del futuro de la cirugía pediátrica está en estas revolucionarias disciplinas [2][3][4] .…”