Tissue Engineering and Its Potential to Reduce Prostate Cancer Treatment Sequelae—Narrative Review

Adamowicz, Jan; Kluth, Luis A.; Pokrywczyńska, Marta

doi:10.3389/fsurg.2021.644057

Cited by 6 publications

(4 citation statements)

References 79 publications

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“…Tissue engineering also shows promise in providing therapeutic opportunities for cancer treatment. Patients suffering from post-prostatectomy incontinence or erectile dysfunction due to prostate cancer, or who need reconstructive surgeries, can be treated with tissue engineering therapies [ 51 , 52 , 53 ]. Bone and other cancers are also treated with the use of tissue-engineered scaffolds [ 54 ].…”

Section: Tissue Engineeringmentioning

confidence: 99%

Current Advances in the Use of Tissue Engineering for Cancer Metastasis Therapeutics

Katti,

Jasuja

2024

Polymers

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Cancer is a leading cause of death worldwide and results in nearly 10 million deaths each year. The global economic burden of cancer from 2020 to 2050 is estimated to be USD 25.2 trillion. The spread of cancer to distant organs through metastasis is the leading cause of death due to cancer. However, as of today, there is no cure for metastasis. Tissue engineering is a promising field for regenerative medicine that is likely to be able to provide rehabilitation procedures to patients who have undergone surgeries, such as mastectomy and other reconstructive procedures. Another important use of tissue engineering has emerged recently that involves the development of realistic and robust in vitro models of cancer metastasis, to aid in drug discovery and new metastasis therapeutics, as well as evaluate cancer biology at metastasis. This review covers the current studies in developing tissue-engineered metastasis structures. This article reports recent developments in in vitro models for breast, prostate, colon, and pancreatic cancer. The review also identifies challenges and opportunities in the use of tissue engineering toward new, clinically relevant therapies that aim to reduce the cancer burden.

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Section: Tissue Engineeringmentioning

confidence: 99%

Current Advances in the Use of Tissue Engineering for Cancer Metastasis Therapeutics

Katti,

Jasuja

2024

Polymers

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“…The use of cell implantable 3D biological scaffolds is believed to allow precise delivery as well as a favorable environment for the stem cells. [ 72 ] Despite these limitations, better understanding, and advancements in material science, the scope is limitless. For instance, various trials have been registered in an attempt to regenerate the urethral sphincter and to salvage the function of erectile tissue.…”

Section: Application Of Newer Technologymentioning

confidence: 99%

Prosthetics in urology: Current status and future directions

Cheriyan

2023

Indian J Urol

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“…During the last decades in the field of biomedicine, enormous efforts have been made to achieve therapies focused on restoring the function of tissues that have suffered critical tissue damage through surgical reconstruction, mechanical devices, or transplants that will provide them with a better quality of life (Klar et al, 2017;Adamowicz et al, 2021). However, the lack of donors and the lack of biocompatible biomaterials prompted the development of adequate and personalized therapies, restoring the function of the injured tissue and organ.…”

Section: Introductionmentioning

confidence: 99%

Biofunctionalization of hydrogel-based scaffolds for vascular tissue regeneration

López-Gutierrez¹,

Ramos‐Payán²,

Ayala-Ham³

et al. 2023

Front. Mater.

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Congenital and acquired tissular losses due to disease or trauma are a major world health problem. Regenerative therapy aims to fix damaged tissues by directing the natural capacity of a host organism to use biofunctionalized artificial tissue scaffolds. These three-dimensional (3D) scaffolds can be customized with cells and/or bioactive molecules to induce cellular homing and angiogenesis, essential to ensure successful tissue regeneration. Hydrogels (HGs) scaffolds are networks of hydrophilic homopolymers, copolymers, and/or macromers with chemical and biological activities that enhance their cell colonization. The use of HGs in regenerative medicine has shown to be advantageous since HGs can be prepared under clinical-grade conditions and tailored to the specific needs of the replaced tissue. They can be made to emulate native extracellular matrices (ECMs) including physical, mechanical, and chemical cues and resilience properties. These customized HGs can reproduce the natural hygroscopic capacity of the original tissue which improves cellular anchoring, nutrition, and waste disposal. They can enable host molecular and cellular modification conducive to a natural cellular microenvironment, modifying the properties of the scaffold, and improving chemotaxis, cell adhesion, migration, proliferation, differentiation, and angiogenesis; HGs can be created and biofunctionalized with linked growth factors and synthetic peptides tailored to positively influence scaffold colonization and functional biocompatibility. This review aims to collect the most relevant information regarding biofunctionalization of HGs used for vascular tissue regeneration, their biological effects, and their clinical implications. While most biofunctionalized HGs are still under investigation, some of them have been studied in vitro, ex vivo, and in vivo with promising results. In this regard, in vivo studies have shown that biofunctionalized scaffolds with peptides such as chitosan hydrogel with LL-37 promotes angiogenesis and healing of pressure ulcers. Also, the GHK tripeptide is widely used in trials focused on guided tissue remodeling.

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Tissue Engineering and Its Potential to Reduce Prostate Cancer Treatment Sequelae—Narrative Review

Cited by 6 publications

References 79 publications

Current Advances in the Use of Tissue Engineering for Cancer Metastasis Therapeutics

Current Advances in the Use of Tissue Engineering for Cancer Metastasis Therapeutics

Prosthetics in urology: Current status and future directions

Biofunctionalization of hydrogel-based scaffolds for vascular tissue regeneration

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