Tissue-engineered chitosan/bioactive glass bone scaffolds integrated with PLGA nanoparticles: A therapeutic design for on-demand drug delivery

Nazemi, K.; Azadpour, P.; Moztarzadeh, F.; Urbanska, Aleksandra M.; Mozafari, Masoud

doi:10.1016/j.matlet.2014.09.086

Cited by 58 publications

(25 citation statements)

References 15 publications

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“…In 2015, Nazemi et al studied the effect of adding PLGA NPs on a chitosan-bioactive glass (chitosan-BG) scaffold revealing that the presence of NPs could increase the mechanical strength of the scaffold, reducing its swelling behavior. Moreover, the addition of NPs makes the system suitable to be implanted as a controlled-release platform of model drugs [143]. The aim of the study carried out by Zhang et al (2015) was to develop and to evaluate CaP composite scaffolds containing simvastatin-loaded PLGA microspheres.…”

Section: Bone Regenerationmentioning

confidence: 99%

Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics

et al. 2020

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Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.

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Section: Bone Regenerationmentioning

confidence: 99%

Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics

et al. 2020

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“…Reinforcement of biomolecules within biodegradable NPs and further insertion of such carriers into tissue-engineered scaffolds will provide a controlledrelease drug delivery system. With this in mind, Nazemi et al [72] investigated the influence of adding PLGA NPs on a chitosan-bioactive glass (CH-BG) scaffold. They prepared two groups of scaffolds (with and without NPs) and studied drug release.…”

Section: Application Of Biodegradable Nanostructure Polymersmentioning

confidence: 99%

Polymeric nanoparticles: Recent development in synthesis and application

Mallakpour¹,

Behranvand²

2016

Express Polym. Lett.

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Abstract. Nanosized particles have attractive characteristics, which have received considerable attention in the last decade. Polymeric nanoparticles (PNP)s are solid particles or particulate dispersions with size in the range of 10-1000 nm. Due to the very small size, the surface area is very large so the percentage of atoms or molecules on the surface is significantly increased, which is expected to have extensive applications in various fields such as drug delivery systems, biosensors, catalysts, nanocomposites, agriculture and environment. The aim of the present paper is to critically review enhancement in the field of synthesis and different application of novel PNPs in various area from drug delivery to composite fabrication. Literature sources were mainly taken from the publications of 2011 and later; though, for a basic depiction of the structural principles, older publications have also been cited. Vol.10, No.11 (2016) 895-913 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2016.84 * Corresponding author, e-mail: mallak@cc.iut.ac.ir © BME-PT of these methods as low cost and safe ways should be highlighted. Furthermore, their importance according to their applications discusses. We will also show some properties of them such as morphology and biological activity. Keywords: biopolymers, biocomposites, polymeric nanoparticles, drug delivery systems, biosensors eXPRESS Polymer Letters

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“…While the resulting nanoparticles can be fabricated of similar sizes and relative compositions as dendrimers, they lack the tight regulation over the number of generations associated with dendrimer synthesis making polymeric nanoparticles significantly more polydisperse. There also exist naturally occurring biodegradable polymers such as collagen and chitosan which have recently become more clinically prevalent [25,26]. …”

Section: Nanoparticle Classesmentioning

confidence: 99%

Emerging Therapeutic Delivery Capabilities and Challenges Utilizing Enzyme/Protein Packaged Bacterial Vesicles

et al. 2015

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Nanoparticle-based therapeutics are poised to play a critical role in treating disease. These complex multifunctional drug delivery vehicles provide for the passive and active targeted delivery of numerous small molecule, peptide and protein-derived pharmaceuticals. This article will first discuss some of the current state of the art nanoparticle classes (dendrimers, lipid-based, polymeric and inorganic), highlighting benefits/drawbacks associated with their implementation. We will then discuss an emerging class of nanoparticle therapeutics, bacterial outer membrane vesicles, that can provide many of the nanoparticle benefits while simplifying assembly. Through molecular biology techniques; outer membrane vesicle hijacking potentially allows for stringent control over nanoparticle production allowing for targeted protein packaged nanoparticles to be fully synthesized by bacteria.

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Tissue-engineered chitosan/bioactive glass bone scaffolds integrated with PLGA nanoparticles: A therapeutic design for on-demand drug delivery

Cited by 58 publications

References 15 publications

Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics

Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics

Polymeric nanoparticles: Recent development in synthesis and application

Emerging Therapeutic Delivery Capabilities and Challenges Utilizing Enzyme/Protein Packaged Bacterial Vesicles

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