Tissue engineered ceramic artificial joint—ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis

Ohgushi, Hajime; Kotobuki, Noriko; Funaoka, Hiroyuki; Machida, Hiroko; Hirose, Motohiro; Tanaka, Yasuhito; Takakura, Yoshinori

doi:10.1016/j.biomaterials.2004.11.055

Cited by 182 publications

(123 citation statements)

References 25 publications

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“…A variety of ceramic products have been clinically applied as biomaterials, and their advantages include high biocompatibility, in vivo stability, and superior mechanical characteristics compared to biomaterials such as synthetic polymers, resins, and metals [1][2][3][4][5][6][7][8][9][10][11][12][13]. Alumina ceramics are particularly effective as biomaterials owing to their high strength, resistance to wear, and smooth surface [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…They are particularly useful in bone repair in orthopedic surgery, and have composed many products for socket or head of hip joint prostheses for more than 20 years [8]. In addition, these ceramic products have already been used clinically in the femoral components of knee joint prostheses and in ankle joint prostheses [9,10]. In other medical fields, ceramics are used as artificial bone to repair cranial and orbital bone defects and as dental and cochlear implants, among other uses [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

et al. 2012

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Aims: The addition of carbon nanotubes (CNTs) remarkably improves the mechanical characteristics of base materials. CNT/alumina ceramic composites are expected to be highly functional biomaterials useful in a variety of medical fields. Biocompatibility and bone tissue compatibility were studied for the application of CNT/alumina composites as biomaterials.Methods & results: Inflammation reactions in response to the composite were as mild as those of alumina ceramic alone in a subcutaneous implantation study. In bone implantation testing, the composite showed good bone tissue compatibility and connected directly to new bone. An in vitro cell attachment test was performed for osteoblasts, chondrocytes, fibroblasts, and smooth muscle cells, and CNT/alumina composite showed cell attachment similar to that of alumina ceramic.Discussion & conclusion: Owing to proven good biocompatibility and bone tissue compatibility, the application of CNT/alumina composites as biomaterials that contact bone, such as prostheses in arthroplasty and devices for bone repair, are expected.4

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

et al. 2012

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“…Also, several signalling molecules are known to be present in the clot; these include platelet-derived growth factor (PDGF) secondary to platelet degranulation. Similarly, Quarto et al (2001) 3 Tibia, ulna, humerus Critical size defect HA Good integration Warnke et al (2004) 1 Mandible Tumour Titanium, bone, BMP Good integration, bone formation Kitoh et al (2004) 3 Mandible Distraction CaCl and PRP Good bone formation Ohgushi et al (2005) 3 Ankle Ankle arthritis Alumina ceramic Good bone formation around arthroplasty 1 Mandible Distraction CaCl and PRP Union and good bone formation 1 Alveolar bone Cleft palate CaCl and PRP 79.1% more bone formation Morishita et al (2006) Warnke et al (2004) reconstructed the mandible of a patient after surgical removal using a titanium construct with incorporated BMP, bone blocks and bone marrow cells. The authors 'endocultivated' the whole construct in the latissimus dorsi of the patient before transfer to the defect area.…”

Section: Treatment Of Bone Lossmentioning

confidence: 99%

“…In addition, BMSCs have been used clinically to augment bone integration into artificial implants and thus decrease loosening. Ohgushi et al (2005) cultured BMSCs on ceramic ankle arthroplasty implants in three patients. Following implantation, the authors found good host bone-implant integration with high clinical scores.…”

Section: Treatment Of Bone Lossmentioning

confidence: 99%

Updates on stem cells and their applications in regenerative medicine

Bajada

Mazakova

Richardson

et al. 2008

J Tissue Eng Regen Med

307

188

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“…10 We have used human MSCs from the patient's bone marrow for treating various diseases centering on bone diseases since 2001. [11][12][13] MSCs and/or osteoblasts differentiated from MSCs have been transplanted into more than 80 patients.…”

Section: Introductionmentioning

confidence: 99%

Restoration of cellular function of mesenchymal stem cells from a hypophosphatasia patient

et al. 2009

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Mesenchymal stem cells (MSCs) can differentiate into multiple cell lineages and are used for regenerative treatments for a variety of diseases. However, the patient's cells cannot be used to treat genetic diseases. Allogeneic cells can serve as an alternative but long-term survival is uncertain. Our experience of allo-transplantation to a patient with hypophosphatasia, which is caused by mutations of the tissue non-specific alkaline phosphatase (TNSALP) gene resulting in low serum alkaline phosphatase (ALP) activity and skeletal deformity, did not improve these clinical characteristics. Therefore, we sought to use autologous MSCs for the treatment of hypophosphatasia. MSCs derived from the patient's bone marrow had a similar profile when compared with well-reported MSCs. However, the MSCs had extremely low ALP activity and could not produce a mineralized bone matrix even under the osteogenic culture conditions. We therefore transduced a retroviral vector with TNSALP promoter-driven TNSALP gene in the MSCs. In the culture condition, the MSCs had about 7-fold higher ALP activity than did mock-transduced MSCs, and showed mineralization as well as bone-specific markers. Furthermore, the MSCs, but not mock-transduced MSCs, newly formed bone at the frequency of 50% in nude rats. Transplantation of the TNSALP-transduced autologous MSCs might become a new therapy for hypophosphatasia.

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Tissue engineered ceramic artificial joint—ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis

Cited by 182 publications

References 25 publications

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

Updates on stem cells and their applications in regenerative medicine

Restoration of cellular function of mesenchymal stem cells from a hypophosphatasia patient

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