Tissue Engineered Cartilage

Ashiku, Simon; Randolph,; Vacanti, Charles A.

doi:10.4028/www.scientific.net/msf.250.129

Cited by 25 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The creation of tissues for medical use is already used to a significant extend in hospitals. These groundbreaking applications involve fabricated skin, 9 liver, 10,11 pancreas, intestines, urothelium, esophagus, 12 nerves, 13 valve leaflet, 14 cartilage, 15 bone, [16][17][18][19] ligament, and tendon. 20 The first commercial application is a bioartificial skin product for burn treatment that was introduced in 1990.…”

Section: Factors Necessary To Enhance the Design Of Scaffolds For Usementioning

confidence: 99%

The Design of Scaffolds for Use in Tissue Engineering. Part I. Traditional Factors

et al. 2001

View full text Add to dashboard Cite

In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods. Advantages and limitations of these traditional methods are also discussed.

show abstract

Section: Factors Necessary To Enhance the Design Of Scaffolds For Usementioning

confidence: 99%

The Design of Scaffolds for Use in Tissue Engineering. Part I. Traditional Factors

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Histological analysis showed viable, phenotypically chondrogenic cells in the defects embedded in a positively‐stained matrix for proteoglycans (Diduch et al , 2000). The application of alginate in cartilage tissue engineering dates back to 1997 (Ashiku et al , 1997) and has since then revealed a constant increasing tendency. However, after 2008 interest in this biomaterial has declined, mainly due to industrial policies and economic reasons (Figure 2).…”

Section: Polysaccharides In Cartilage Tissue Engineeringmentioning

confidence: 99%

Polysaccharide-based materials for cartilage tissue engineering applications

Oliveira

Reis

2010

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Tissue engineering was proposed approximately 15 years ago as an alternative and innovative way to address tissue regeneration problems. During the development of this field, researchers have proposed a variety of ways of looking into the regeneration and engineering of tissues, using different types of materials coupled with a wide range of cells and bioactive agents. This trilogy is commonly considered the basis of a tissue-engineering strategy, meaning by this the use of a support material, cells and bioactive agents. Different researchers have been adding to these basic approaches other parameters able to improve the functionality of the tissue-engineered construct, such as specific mechanical environments and conditioned gaseous atmospheres, among others. Nowadays, tissue-engineering principles have been applied, with different degrees of success, to almost every tissue lacking efficient regeneration ability and the knowledge and intellectual property produced since then has experienced an immense growth. Materials for regenerating tissues, namely cartilage, have also been continuously increasing and most of the theoretical requirements for a tissue engineering support have been addressed by a single material or a mixture of materials. Due to their intrinsic features, polysaccharides are interesting for cartilage tissue-engineering approaches and as a result their exploitation for this purpose has been increasing. The present paper intends to provide an overview of some of the most relevant polysaccharides used in cartilage tissue-engineering research.

show abstract

“…Compared to other surgical methods, the main advantage of using cartilage cultured in vitro with speciÿc 3-D shapes lies in the recovery of tissue damage without any risk of tissue rejection by the patient since the culture could be initiated with the patient's cells. Typically, in this technique, cartilage is formed from chondrocytes cultured in an agitated bio-reactor on synthetic polymeric sca olds made of a felt of biodegradable polymer ÿbres like poly-glycolic or poly-lactic acid (Ashiku et al, 1997). The use of such substances provides a safe environment free of viruses and bacteria (Freed et al, 1993).…”

Section: Introductionmentioning

confidence: 99%