Tissue engineered bone as an alternative for repairing bone defects

Abstract

Background: Dentist es�ecially �ral s�rge�n, are �req�ently �aced ��it� de�ect in ��ne res�lting �r�� disease �r tra��a. �� t�e de�ect is s�all, it ��ill �req�ently �as a g��d �ealing, ����ever, i� t�e de�ect is larger, inc���lete regenerati�n ��ten �cc�rs and a �i�r��s scar res�lts. �rans�lantati�n �� a�t�gen��s ��ne �as �een �ne �� t�e ��st �req�ent �r�ced�res �� rec�nstr�ctive �ral and �a�ill��acial s�rgery �eca�se it �as s����n e�cellent clinical s�ccess; ����ever, a�t�gen��s ��ne gra�ting is ��ten related t� disadvantages like li�ited availa�ility, and d�n�r ��r�idity. Purpose: ��e ��r��se �� t�is revie�� is t� e��lain t�e �asic �rinci�les �� tiss�e engineering, �ackgr��nd �� regenerati�n �r�cess, als� advantages and disadvantages �� tiss�e engineered ��ne c���ared t� a�t�gen��s ��ne gra�t. review: Recently, tiss�e engineered ��ne �r�vides a �r��ising strategic inn�vati�n and �ec��es a ne�� alternative ��r ��ne regenerati�n �r�cess. �iss�e engineering is a ter� �riginally �sed t� descri�e tiss�e �r�d�ced in is�lati�n and c�lt�re �y cells seeded in vari��s ��r��s a�s�r�a�le �atrices. �iss�e engineering generally c���ines t�ree key ele�ents (�iss�e Engineering �riad) i.e: sca���lds (�atrices), signaling ��lec�les (gr���t� �act�rs), and cells (�ste��last, �i�r��last, etc). Conclusion: �iss�e engineering ��ill �acilitate initial ��ne �ealing in �rder t� acc���lis� tiss�e regenerati�n �r�cess. abstrak latar belakang: Se�rang d�kter gigi k��s�snya d�kter gigi �eda� ��l�t, seringkali di�ada�kan dengan keadaan de�ek t�lang aki�at dari s�at� �enyakit ata� tra��a. Jika de�eknya kecil ��ngkin da�at se���� dengan �aik, teta�i �ila de�eknya �esar, ke��ngkinan regenerasi t�lang tidak se���rna dan �eng�asilkan scar/ jaringan �ar�t. �rans�lantasi dengan �engg�nakan a�t�gen��s ��ne gra�t �eski��n sa��ai saat ini �asi� �anyak dig�nakan �nt�k ��erasi rek�nstr�ksi di �idang �eda� ��l�t dan �aksil��asial karena tela� �en�nj�kkan ke�er�asilan klinik yang c�k�� �aik, na��n cara ini �e���nyai �anyak kek�rangan, diantaranya ��r�iditas dari sisi d�n�r. tujuan: ��j�an dari �en�lisan ini adala� �nt�k �enjelaskan tentang �rinsi�-�rinsi� dasar tiss�e engineering, �al-�al yang �er�eran dala� �r�ses regenerasi serta ke�nt�ngan dan ker�gian tiss�e engineering di�andingkan dengan a�t�gen��s ��ne gra�t. tinjauan pustaka: Saat ini �engg�naan tiss�e engineered ��ne �er��akan s�at� strategi in�vati� yang tela� dike��angkan dan �e��erikan s�at� alternati� dala� �r�ses regenerasi t�lang. �iss�e engineering ata� rekayasa jaringan �er��akan s�at� istila� yang dig�nakan �nt�k �enjelaskan �agai�ana s�at� jaringan di�asilkan dengan cara is�lasi dan k�lt�r sel dala� �er�agai �atriks ��r��s a�s�r�le. �iss�e engineering akan �eli�atkan tiga ele�en k�nci (tiss�e engineering triad) yait� Sca���ld (�atriks), ��lek�l-��lek�l signal (gr���t� �act�rs) dan sel-sel (�ste��last, �i�r��last, dll). Kesimpulan: �eknik tiss�e engineering akan �e��asilitasi �r�ses a��al �enye����an t�lang se�ingga �r�ses regenerasi jaringan akan terca�ai.