Tissue elasticity reconstruction based on ultrasonic displacement and strain images

Skovoroda, A.R.; Emelianov, Stanislav; O’Donnell, Matthew

doi:10.1109/58.393117

Cited by 241 publications

(199 citation statements)

References 24 publications

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“…These estimates are, of course, influenced by the well-known strain intensification effects that occur at boundaries of tissues of different Young's modulus during deformations (Ponnekanti et al 1994;Kallel et al 1996). Strain distributions are also influenced by boundary conditions and assumptions regarding homogeneity of the materials surrounding thrombi (Skovoroda et al 1995;Kallel et al 1996;Doyley et al 2000). Thus, strain measurements provide only approximate measures of the underling Young's modulus distribution in tissue.…”

Section: Introductionmentioning

confidence: 99%

Correspondence of ultrasound elasticity imaging to direct mechanical measurement in aging DVT in rats

Xie

Kim

Aglyamov

et al. 2005

Ultrasound in Medicine & Biology

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Previous ultrasound elasticity imaging experiments supported a generally accepted concept that the hardness of deep venous thrombi increases with thrombus aging. Results also showed that this noninvasive imaging technique can accurately predict thrombus age through strain estimates in a well controlled animal study. In the present study, as an alternative means to characterize elastic properties of thrombi, we employed a direct mechanical measurement system to estimate Young's modulus of ex vivo thrombi. Unlike conventional indentation tests, the device utilizes a specific compression geometry for cylindrical tissue specimens. We also proposed an approximation scheme to retrieve Young's modulus from force-displacement measurements made using the device. Finite element simulations and calibrations on tissue-mimicking phantoms validated the system. Then, using two groups of rats with surgically induced thrombi, we further investigated the correlation between Young's modulus measured ex vivo and elasticity images reconstructed in vivo. This comparison was accomplished by converting the intra-thrombus strains measured in the in vivo studies into Young's modulus estimates using a model based approach. Good agreement between time-dependent Young's modulus estimates observed in vivo and direct measurements of Young's modulus using the mechanical device helps to confirm the ability of elasticity imaging to age DVT for efficient treatment.

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Section: Introductionmentioning

confidence: 99%

Correspondence of ultrasound elasticity imaging to direct mechanical measurement in aging DVT in rats

Xie

Kim

Aglyamov

et al. 2005

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…The elastic wave velocity, c, was then obtained by the inverse slope of the linear fit of the propagation distances, Δd, to the elastic wave propagation delays, Δt [42]. Since the tissue-mimicking agar phantoms can be treated as an isotropic homogeneous elastic material, the Young's modulus [43], E, was estimated by [23,40,44]:…”

Section: J Of Biomedical Photonics and Eng 1(4)mentioning

confidence: 99%

Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

Liu

Schill

et al. 2015

JBPE

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Abstract. Purpose: Elastography is an emerging method for detecting the pathological changes in tissue biomechanical properties caused by various diseases. In this study, we have compared two methods of noncontact optical elastography for quantifying Young's modulus of tissue-mimicking agar phantoms of various concentrations: a laser Michelson interferometric vibrometer and a phase-stabilized swept source optical coherence elastography system. Methods: The elasticity of the phantoms was estimated from the velocity of air-pulse induced elastic waves as measured by these two techniques. Results: The results show that both techniques were able to accurately assess the elasticity of the samples as compared to uniaxial mechanical compression testing. Conclusion: The laser Michelson interferometric vibrometer is significantly more cost-effective, but it cannot directly provide the elastic wave temporal profile, nor can it offer in-depth information.

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“…Determination of the mechanical behaviour of biological tissues is a key issue in the early detection of cancerous tumours (stiff tumours embedded in softer tissues) or in the production of data to establish models of the human body for crash simulation, for instance. The determination of stiffness from such measurements is known as "elastography" in the medical community [23,24]. These tissues also exhibit highly non linear behaviour (hyperviscoelastic for muscle tissues, for instance) and there is still much work to do both on the measurements themselves (moving from images to high quality deformation measurements) and on the identification procedures.…”

Section: Stiffness Reductionmentioning

confidence: 99%

Identification of Materials Mechanical Properties from Full-Field Measurements: Latest Advances in the Virtual Fields Method

Pierron

2008

AMM

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Abstract. This paper presents a short overview of the state of the art and future challenges of the use of full-field measurements and inverse procedures to identify the constitutive mechanical parameters of a wide range of materials. It concentrates on the so-called Virtual Fields Method (VFM) which is a tool fully dedicated to the processing of full-field measurements. Some of the future challenges are briefly covered here, namely the design of test configurations and the application to damage assessment, high strain rate testing and biomaterials. Some examples are given and the main scientific issues briefly discussed.

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Tissue elasticity reconstruction based on ultrasonic displacement and strain images

Cited by 241 publications

References 24 publications

Correspondence of ultrasound elasticity imaging to direct mechanical measurement in aging DVT in rats

Correspondence of ultrasound elasticity imaging to direct mechanical measurement in aging DVT in rats

Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

Identification of Materials Mechanical Properties from Full-Field Measurements: Latest Advances in the Virtual Fields Method

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