Tissue Doppler Imaging of the Diaphragm: A New Kid on the Block?

McCool, F. Dennis; Tzelepis, George E.

doi:10.1164/rccm.202007-2771ed

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…The diaphragm is the primary inspiratory muscle during breathing, and its movement is restricted with decreased compliance ( 23 - 25 ). Ultrasound has emerged as a widely used method for monitoring diaphragm function in patients with chronic obstructive pulmonary disease ( 26 - 28 ). Our study is the first to evaluate diaphragmatic muscle function using ultrasound as a proxy for changes in IAP.…”

Section: Discussionmentioning

confidence: 99%

A nomogram for predicting the risk of intra-abdominal hypertension in critically ill patients based on ultrasound and clinical data

Chen,

Yang,

Lyu

et al. 2023

Quant Imaging Med Surg

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Background Intra-abdominal hypertension (IAH) is a common complication in critically ill patients. This study aimed to identify independent risk factors for IAH and generate a nomogram to distinguish IAH from non-IAH in these patients. Methods We retrospectively analyzed 89 critically ill patients and divided them into an IAH group [intra-abdominal pressure (IAP) ≥12 mmHg] and a non-IAH group (IAP <12 mmHg) based on the IAP measured from their bladders. Ultrasound and clinical data were also measured. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for IAH. The correlation between IAP and independent risk factors was also assessed. Results Of these 89 patients, 45 (51%) were diagnosed with IAH. Univariate analysis showed there were significant differences in the right renal resistance index (RRRI) of the interlobar artery, the right diaphragm thickening rate (RDTR), and lactic acid (Lac) between IAH and non-IAH groups (P<0.001). Multivariate logistic regression analysis revealed that increasing RRRI, RDTR, and Lactic acid (Lac) were independent risk factors for IAH (P=0.001, P=0.001, and P=0.039, respectively). IAP was significantly correlated with RRRI, RDTR, and Lac (r=0.741, r=−0.774, and r=0.396, respectively; P<0.001). The prediction model based on regression analysis results was expressed as follows: predictive score = −17.274 + 31.125 × RRRI − 29.074 × RDTR + 0.621 × Lac. Meanwhile, the IAH nomogram prediction model was established with an area under the receiver operating characteristic (ROC) curve of 0.956 (95% confidence interval: 0.909–1.000). The nomogram showed good calibration for IAH with the Hosmer-Lemeshow test (P=0.864) and was found to be applicable within a wide threshold probability range, especially that higher than 0.40. Conclusions The noninvasive nomogram based on ultrasound and clinical data has good diagnostic efficiency and can predict the risk of IAH. This nomogram may provide valuable guidance for clinical interventions to reduce IAH morbidity and mortality in critically ill patients.

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Section: Discussionmentioning

confidence: 99%

A nomogram for predicting the risk of intra-abdominal hypertension in critically ill patients based on ultrasound and clinical data

Chen,

Yang,

Lyu

et al. 2023

Quant Imaging Med Surg

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“…Although the preliminary results are very significant, it is important to point out that much progress is still needed in the standardization of the method that includes the determination of the diaphragmatic movement point of interest (ROI); influence of other factors, such as compliance of the rib cage and activation of accessory inspiratory and expiratory muscles [ 114 ].…”

Section: Novel Techniques and Future Developments For Functional Imag...mentioning

confidence: 99%

Diaphragm Ultrasound in Critically Ill Patients on Mechanical Ventilation—Evolving Concepts

Cardenas

Baldi

2023

Diagnostics

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Mechanical ventilation (MV) is a life-saving respiratory support therapy, but MV can lead to diaphragm muscle injury (myotrauma) and induce diaphragmatic dysfunction (DD). DD is relevant because it is highly prevalent and associated with significant adverse outcomes, including prolonged ventilation, weaning failures, and mortality. The main mechanisms involved in the occurrence of myotrauma are associated with inadequate MV support in adapting to the patient’s respiratory effort (over- and under-assistance) and as a result of patient-ventilator asynchrony (PVA). The recognition of these mechanisms associated with myotrauma forced the development of myotrauma prevention strategies (MV with diaphragm protection), mainly based on titration of appropriate levels of inspiratory effort (to avoid over- and under-assistance) and to avoid PVA. Protecting the diaphragm during MV therefore requires the use of tools to monitor diaphragmatic effort and detect PVA. Diaphragm ultrasound is a non-invasive technique that can be used to monitor diaphragm function, to assess PVA, and potentially help to define diaphragmatic effort with protective ventilation. This review aims to provide clinicians with an overview of the relevance of DD and the main mechanisms underlying myotrauma, as well as the most current strategies aimed at minimizing the occurrence of myotrauma with special emphasis on the role of ultrasound in monitoring diaphragm function.

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“…However, since we focused on the ultrasound test that was supported by the most evidence of validation at the time of data collection [16, 23-25, 30, 31], a cutaneous marker was not applied to minimize the variability of the ultrasound measurements, as described by Goligher et al [23]. In addition, advanced tools that are used to evaluate diaphragmatic function, such as tissue Doppler and speckle tracking, were not utilized [36][37][38][39].…”

Section: Limitationsmentioning

confidence: 99%

Utilization of spontaneous breathing trial, objective cough test, and diaphragmatic ultrasound results to predict extubation success: COBRE-US trial

Varón-Vega,

Giraldo-Cadavid,

Uribe

et al. 2023

Crit Care

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Background The results of clinical and weaning readiness tests and the spontaneous breathing trial (SBT) are used to predict the success of the weaning process and extubation. Methods We evaluated the capacity of the cuff leak test, rate of rapid and shallow breathing, cough intensity, and diaphragmatic contraction velocity (DCV) to predict the success of the SBT and extubation in a prospective, multicenter observational study with consecutive adult patients admitted to four intensive care units. We used receiver operating characteristic (ROC) curves to assess the tests’ predictive capacity and built predictive models using logistic regression. Results We recruited 367 subjects who were receiving invasive mechanical ventilation and on whom 456 SBTs were performed, with a success rate of 76.5%. To predict the success of the SBT, we derived the following equation: (0.56 × Cough) − (0.13 × DCV) + 0.25. When the cutoff point was ≥ 0.83, the sensitivity was 91.5%, the specificity was 22.1%, and the overall accuracy was 76.2%. The area under the ROC curve (AUC-ROC) was 0.63. To predict extubation success, we derived the following equation: (5.7 × SBT) + (0.75 × Cough) − (0.25 × DCV) − 4.5. When the cutoff point was ≥ 1.25, the sensitivity was 96.8%, the specificity was 78.4%, and the overall accuracy was 91.5%. The AUC-ROC of this model was 0.91. Conclusion Objective measurement of cough and diaphragmatic contraction velocity could be used to predict SBT success. The equation for predicting successful extubation, which includes SBT, cough, and diaphragmatic contraction velocity values, showed excellent discriminative capacity.

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Tissue Doppler Imaging of the Diaphragm: A New Kid on the Block?

Cited by 5 publications

References 16 publications

A nomogram for predicting the risk of intra-abdominal hypertension in critically ill patients based on ultrasound and clinical data

A nomogram for predicting the risk of intra-abdominal hypertension in critically ill patients based on ultrasound and clinical data

Diaphragm Ultrasound in Critically Ill Patients on Mechanical Ventilation—Evolving Concepts

Utilization of spontaneous breathing trial, objective cough test, and diaphragmatic ultrasound results to predict extubation success: COBRE-US trial

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