Tissue Doppler Imaging in the horse

Gehlen, Heidrun; Iversen, C.; Štádler, P

doi:10.21836/pem20090101

Cited by 2 publications

(2 citation statements)

References 13 publications

(23 reference statements)

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“…Therefore, assessing all segments and the inclusion of longitudinal measurements would have allowed us to assess the complex movement of the heart more in detail. Such longitudinal measurements are available in STE as has been recently shown [ 32 33 34 ], but are technically not feasible for TDE in horse [ 35 36 37 ]. Concerning the TDE, rapid movement, such as the isovolumetric contraction and relaxation, are difficult to measure in horses [ 35 36 38 ] because the frame rate is often limited when high image depth is needed, for example, in EchCG in horses.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on the effects of pergolide on left ventricular function in the horses with pituitary pars intermedia dysfunction

2021

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Background Pituitary pars intermedia dysfunction (PPID), a neurodegenerative disease leading to reduced dopamine production, is a common disease in aged horses. The treatment is based on administration of the dopamine agonist pergolide. This drug has been related to valvular fibrosis in humans, but the cardiovascular effect of this drug has not yet been investigated in horses. Objectives To determine whether pergolide induces valvular disease in horses or affects the cardiac function. Methods Standard, tissue Doppler (TDE) and two-dimensional speckle tracking (STE) echocardiography were performed in horses with diagnosed PPID based on adrenocorticotropic hormone dosage. Measurements taken in horses treated with pergolide were compared with those from untreated horses with nonparametric t -tests. Furthermore, measurements from follow-up examinations performed at least three months after the initial exam were compared with a Wilcoxon signed rank test for repeated measurements in each group. Results Twenty-three horses were included. None of the 12 horses under treatment developed valvular regurgitation. Furthermore, no differences in the measurements of the left ventricular systolic or diastolic function could be seen between the group of horses with treatment and those without treatment. Measurements taken in the follow-up exam did not differ compared to those taken in the initial exam in both groups. Conclusions No changes of the left ventricular function assessed by TDE and STE could be shown in a small population of horses with confirmed PPID. Treatment with pergolide did not affect the ventricular function nor induce valvular disease.

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Section: Discussionmentioning

confidence: 99%

Preliminary study on the effects of pergolide on left ventricular function in the horses with pituitary pars intermedia dysfunction

2021

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“…In veterinary medicine, for different reasons thrombosis is seen less frequently than in human medicine, except for equine patients. Similar to human patients, horses often display severe vascular complications in the context of chronic inflammatory processes, especially after intravenous interventions [17,32,35]. In fact, equine vessels have been described to be more susceptible to chemical or mechanical manipulation 128…”

Section: Introductionmentioning

confidence: 99%

Isolation of equine endothelial cells and life cell angiogenesis assay

Dietze

Slosarek

Fuhrmann-Selter

et al. 2014

Clinical Hemorheology and Microcirculation

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Arterial or venous thromboses are frequent clinical complications with the risk of fatal progression. Recent studies suggest the disruption of angiogenesis in the course of thrombus resolution as the underlying pathomechanism. Very similar to the situation in human patients, equine vessels have been described to be particularly susceptible to thrombosis. In contrast to humans, equine donors are readily available to obtain organs and tissues for isolation of endothelial cells. Objective of this study was to isolate equine endothelial cells and develop an angiogenesis assay from primary cultures. Macrovascular endothelial cells were obtained from jugular veins and carotid arteries of nine horses, one of which suffered from inflammatory processes. After enzymatic isolation, the cells were incubated in different selective primary media. Phenotypic identification of endothelial cells was accomplished by morphology and positive staining to von Willebrand factor. The reliable, inexpensive, and standardized combination of methods presented here resulted in pure endothelial cultures for angiogenesis assays that can be used in any cell culture laboratory. Inverted phase microscopy and life cell imaging was used to characterize the stages of the angiogenic cascade of the endothelial cells. Life cell imaging gave new insights into the in vitro formation of capillary like structures including exocytosis of microparticles from endothelial cells before integration into the three-dimensional structure. We hypothesize that a specific population of endothelial cells showing a highly active migration pattern in life cell imaging might play a role in the resolution of thrombosis.

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Tissue Doppler Imaging in the horse

Cited by 2 publications

References 13 publications

Preliminary study on the effects of pergolide on left ventricular function in the horses with pituitary pars intermedia dysfunction

Preliminary study on the effects of pergolide on left ventricular function in the horses with pituitary pars intermedia dysfunction

Isolation of equine endothelial cells and life cell angiogenesis assay

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