Tissue Doppler imaging in detection of myocardial dysfunction in survivors of childhood cancer treated with anthracyclines

Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

“…Both prolonged isovolumic relaxation time and an increased myocardial performance index late after treatment reportedly can indicate anthracycline-induced cardiotoxicity in the presence of normal LV ejection fraction. 203,240,262,263 Myocardial strain is a dimensionless measure of regional and global ventricular deformation. Myocardial strain rate, a time derivative of strain, correlates with LV peak elastance, which is a load-independent global measure of ventricular systolic function.…”

Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

“…When this technology is not available, the quantitation of LV longitudinal function by simple ultrasound tools such as mitral annular plane systolic excursion by M-mode echocardiography, and/or the peak systolic velocity (s ′ ) of the mitral annulus by pulsed-wave DTI, could be useful adjunct information to LVEF in the evaluation of LV systolic function. [45][46][47][48][49] Mitral annular plane systolic excursion is less dependent on image quality. Although there are no cut-off values that allow the prediction of CTRCD, a progressive decline should raise concern for sub-clinical LV dysfunction.…”

Possibilities of early detection of cardiotoxicity in patients with malignancy

“…This is only a small change in the size, which was not associated with either a clinical deterioration of the circulatory status or a significant change in the pump function. Similarly to our study, several authors described a non-significant enlargement (61,62), a process that was not followed by a substantial deterioration of the ejection fraction in our case.…”