Tissue Doppler Imaging and Plasma BNP Levels to Assess the Prognosis in Patients with Hypertrophic Cardiomyopathy

Kitaoka, Hiroaki; Kubo, Toru; Okawa, Makoto; Takenaka, Nana; Sakamoto, Chiyo; Baba, Yuichi; Hayashi, Kamichika; Yamasaki, Naohito; Matsumura, Yuichi; Doi, Yoshinori

doi:10.1016/j.echo.2011.05.009

Cited by 54 publications

(39 citation statements)

References 33 publications

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“…These histopathological changes result in a diastolic dysfunction and, later in the disease course, might also provoke systolic longitudinal function impairment, which is associated with poor prognosis [24,25]. In patients with heart failure, MAPSE correlated with parameters of systolic longitudinal and diastolic dysfunction as well as with left ventricular twist and torsion [5].…”

Section: Discussionmentioning

confidence: 98%

Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Doesch

Sperb

Sudarski³

et al. 2015

Archives of Cardiovascular Diseases

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MAPSE measurement using CMR is feasible, reproducible and comparable to echocardiography in healthy controls and patients with HCM. The asymmetric and mainly septal distribution of myocardial hypertrophy and fibrosis detected by LGE in patients with HCM was reflected by significantly reduced septal versus lateral MAPSE. Therefore, reduced MAPSE seems to be an easily determinable marker of fibrosis accumulation leading to left ventricular mechanical dysfunction and also seems to have a prognostic implication.

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Section: Discussionmentioning

confidence: 98%

Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Doesch

Sperb

Sudarski³

et al. 2015

Archives of Cardiovascular Diseases

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“…Nonetheless, our present results suggest that the BNP level has a significant value as an integrated biomarker reflecting several cardiovascular risk factors as shown in the present study (aging, BMI, LVOT obstruction, LAD, LVM, and LVFM). Other factors relevant to the BNP levels, such as renal function, EDWS, and diastolic function, may contribute to the prognosis (9,26,27). Furthermore, the plasma BNP level may be more sensitive than the LVM or LVFM for the prognosis in the HCM cohort.…”

Section: Prognostic Markers Of Hcmmentioning

confidence: 99%

Interrelationship between the Myocardial Mass, Fibrosis, BNP, and Clinical Outcomes in Hypertrophic Cardiomyopathy

et al. 2016

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Objective Increased left ventricular mass (LVM) and LV fibrosis mass (LVFM) are characteristics of hypertrophic cardiomyopathy (HCM). Additionally, a substantial increase in the plasma B-type natriuretic peptide (BNP) level is observed. Therefore, we investigated the interrelationship and clinical significances of these parameters in a HCM cohort that underwent cardiac MRI (CMR). Methods Patients with HCM (n=109) receiving regular outpatient treatment underwent CMR and follow-up through 2015 from CMR examinations. The clinical outcome measures were all-cause mortality, admission for worsening heart failure, and ventricular tachycardia/fibrillation. Results The baseline body mass index (BMI), LV outflow tract (LVOT) obstruction, New York Heart Association (NYHA) class, and increased left atrial dimension (LAD) index were associated with the plasma BNP level. In the CMR analysis, LVM and LVFM indices significantly correlated with the BNP level (r=0.422 and 0.368, respectively), which were independent determinants according to a multivariate analysis (p=0.009 and 0.023, respectively). A Kaplan-Meier analysis during a median follow-up of 19.4 months showed that the baseline LVM or LVFM index was not associated with the clinical outcomes. However, the baseline BNP level was significantly associated with them (p<0.001). In addition, a multivariate Cox proportional hazard analysis showed that plasma BNP was an independent predictor for the clinical outcomes after adjusting for age, sex, LVM, and LVFM. Conclusion The LVM and LVFM are determinants of the BNP level independent of the BMI, LVOT obstruction, LAD, and NYHA class in patients with HCM. However, plasma BNP may be a more sensitive integrated-marker for the clinical outcomes than LVM or LVFM.

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“…7,8 The development of an anteroposterior LA diameter > 48 mm was associated with an increased risk for all-cause, HCM-related, and heart failure-related death (but not SCD). 9 More recent echocardiographic studies with smaller HCM cohorts and shorter observation periods have explored additional Doppler echocardiographic measures, LA volume indexed to body surface area, 10 and Doppler tissue imaging, 11,12 to further refine the risk assessment of patients. The detection of an LA volume index > 27 mL/m 2 , 10 a Doppler tissue imaging lateral annular systolic velocity < 4 cm/sec, 11 and a septal E/e 0 ratio > 15 12 impart an increased risk for HCM-related events.…”

Section: Risk Assessment In Patients With Hypertrophic Cardiomyopathymentioning

confidence: 99%

Echocardiography in Hypertrophic Cardiomyopathy: In with Strain, Out with Straining?

Chun

Woo

2015

Journal of the American Society of Echocardiography

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Tissue Doppler Imaging and Plasma BNP Levels to Assess the Prognosis in Patients with Hypertrophic Cardiomyopathy

Cited by 54 publications

References 33 publications

Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Interrelationship between the Myocardial Mass, Fibrosis, BNP, and Clinical Outcomes in Hypertrophic Cardiomyopathy

Echocardiography in Hypertrophic Cardiomyopathy: In with Strain, Out with Straining?

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