Tissue distribution of the P2X7 receptor

Collo, Ginetta; Neidhart, Sybille; Kawashima, Eric; Kosco‐Vilbois, Marie H.; North, Richard; Buell, Gary

doi:10.1016/s0028-3908(97)00140-8

Cited by 460 publications

(346 citation statements)

References 26 publications

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“…In 1997, Collo et al noted expression of P2X7 in the developing vertebrae and mandible of E19 rat embryos by in situ hybridization (Fig. 2) [24]. More recently, the phenotype of mice with targeted disruption of the gene encoding the P2X7 receptor (P2rx7) has been described, suggesting a role for this receptor in the regulation of bone formation and resorption [25] and in mechanotransduction [26].…”

Section: P2x7 In Bonementioning

confidence: 98%

“…Positive staining for P2X7 receptor mRNA was seen in the developing vertebrae (dark staining, arrowheads) and mandible (arrow) providing evidence for expression of the P2X7 receptor in bone. Modified from [24], copyright 1997, with permission from Elsevier detected in osteoblast-enriched cultures of rat calvarial cells [28]. A subsequent study conducted by Gartland et al localized the P2X7 receptor to a subpopulation of human bone-derived cells in vitro using immunocytochemical analyses and pore-formation assays [29].…”

Section: Expression Of P2x7 In Cells Of the Osteoblast Lineagementioning

confidence: 99%

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Expression, signaling, and function of P2X7 receptors in bone

Grol

Panupinthu

Korcok

et al. 2009

Purinergic Signalling

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Nucleotides released from cells in response to mechanical stimulation or injury may serve as paracrine regulators of bone cell function. Extracellular nucleotides bind to multiple subtypes of P2 receptors on osteoblasts (the cells responsible for bone formation) and osteoclasts (cells with the unique ability to resorb mineralized tissues). Both cell lineages express the P2X7 receptor subtype. The skeletal phenotype of mice with targeted disruption of P2rx7 points to interesting roles for this receptor in the regulation of bone formation and resorption, as well as the response of the skeleton to mechanical stimulation. This paper reviews recent work on the expression of P2X7 receptors in bone, their associated signal transduction mechanisms and roles in regulating bone formation and resorption. Areas for future research in this field are also discussed.

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Section: P2x7 In Bonementioning

confidence: 98%

Section: Expression Of P2x7 In Cells Of the Osteoblast Lineagementioning

confidence: 99%

Expression, signaling, and function of P2X7 receptors in bone

Grol

Panupinthu

Korcok

et al. 2009

Purinergic Signalling

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“…The stoichiometry of P2X 7 R involves a trimeric pore that consists of homomultimers [23]. The P2X 7 R is predominantly expressed on cells of hematopoietic origin such as monocytes [24], dendritic cells, T and B lymphocytes, eosinophils, mast cells, but also on various types of glia within the peripheral and central nervous system including microglia, astrocytes, oligodendrocytes, and Schwann cells [25,26]. Moreover, P2X 7 R protein is expressed on epithelial cells, osteoblasts, synoviocytes, and fibroblasts [27][28][29][30].…”

Section: P2x 7 Rmentioning

confidence: 99%

The role of P2X7 receptors in tissue fibrosis: a brief review

Gentile

Natale

Lazzerini

et al. 2015

Purinergic Signalling

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Many previous studies have demonstrated that P2X 7 receptors (P2X 7 Rs) have a pleiotropic function in different pathological conditions and could represent a novel target for the treatment of a range of diseases. In particular, recent studies have explored the role of P2X 7 R in fibrosis, the pathological outcome of most chronic inflammatory diseases. The aim of this review is to discuss the biological features of P2X 7 R and summarize the current knowledge about the putative role of the P2X 7 R in triggering fibrosis in a wide spectrum of organs such as the lung, kidney, liver, pancreas, and heart.

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“…68,69 Verderio and Matteoli 69 showed that intracellular Ca 2 þ waves induced the release of ATP by astrocytes, which in turn triggered a Ca 2 þ response in microglia via P2X 7 receptors. There is evidence that P2X 7 receptors are upregulated in activated microglia following brain ischaemic injury, 70 in Mü ller glial cells during proliferative vitreoretinopathy, 71 and in reactive astrocytes in the enucleated optic nerve (Figure 6c). 72 NG2-glia (synantocytes): physiological and pathological functions of novel mature glia A significant population of glial cells has been identified in both grey and white matter that express the NG2 chondroitin sulphate proteoglycan (CSPG).…”

Section: Atp-evoked Ca 2 þ Signalling In Physiology and Pathologymentioning

confidence: 99%

Functions of optic nerve glia: axoglial signalling in physiology and pathology

Butt

Pugh

Hubbard

et al. 2004

Eye

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An early concept of glial function envisaged them as passive and unexcitable structural elements, much like the connective tissues of organs in the periphery. It is now known that glia have a widespread range of physiological roles and react to all forms of pathological insult. This paper reviews the major functions of oligodendrocytes and astrocytes, the main types of glia in the optic nerve, and examines novel NG2-glia, otherwise known as oligodendrocyte progenitor cells (OPCs). The major function of oligodendrocytes is to produce the myelin sheaths that insulate CNS axons, but they also have important roles in the establishment of nodes of Ranvier, the sites of action potential propagation, and axonal integrity. Astrocytes have multiple physiological and pathological functions, including potassium homeostasis and metabolism, and reactive astrogliosis in response to CNS insults. The bulk of NG2-glia are postmitotic complex cells, distinct from OPCs, and respond to any insult to the CNS by a rapid and stereotypic injury response. This may be their primary unction, but NG2-glia, or a subpopulation of NG2-expressing adult OPCs, also provide remyelinating oligodendrocytes following demyelination. Oligodendrocytes, astrocytes, and NG2-glia all contact axons at nodes of Ranvier and respond to glutamate, ATP, and potassium released during axonal electrical activity. Glutamate and ATP evoke calcium signalling in optic nerve glia and have dual roles in physiology and pathology, coupling glial functions to axonal activity during normal activity, but enhanced activation induces an injury response, as seen following injury, demyelination, and ischaemia.

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Tissue distribution of the P2X7 receptor

Cited by 460 publications

References 26 publications

Expression, signaling, and function of P2X7 receptors in bone

Expression, signaling, and function of P2X7 receptors in bone

The role of P2X7 receptors in tissue fibrosis: a brief review

Functions of optic nerve glia: axoglial signalling in physiology and pathology

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