Tissue distribution of the 1,25-dihydroxyvitamin D3 receptor in the male rat

Sandgren, Maria E.; Brönnegård, Mikael; DeLuca, Hector F.

doi:10.1016/0006-291x(91)91234-4

Cited by 94 publications

(60 citation statements)

References 27 publications

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“…2 Apart from playing a recognized role in suppressing secondary hyperparathyroidism, vitamin D has been suggested to play a protective role against cardiovascular disease and exert its effects on the heart and vascular walls through interaction with the vitamin D receptor. 3,4 Experimental studies showed associations between vitamin D deficiency and impairment of cardiac contractile function, 5 increased myocardial collagen content, and increased cardiac mass. 6,7 Similarly, targeted deletion of the vitamin D receptor gene resulted in increased cardiomyocyte size and LV weight.…”

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confidence: 99%

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD—The OPERA Trial

Wang

Fang

Chan

et al. 2014

Journal of the American Society of Nephrology

222

192

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Vitamin D seems to protect against cardiovascular disease, but the reported effects of vitamin D on patient outcomes in CKD are controversial. We conducted a prospective, double blind, randomized, placebocontrolled trial to determine whether oral activated vitamin D reduces left ventricular (LV) mass in patients with stages 3-5 CKD with LV hypertrophy. Subjects with echocardiographic criteria of LV hypertrophy were randomly assigned to receive either oral paricalcitol (1 mg) one time daily (n=30) or matching placebo (n=30) for 52 weeks. The primary end point was change in LV mass index over 52 weeks, which was measured by cardiac magnetic resonance imaging. early diastolic and systolic mitral annular velocities, and ratio of early mitral inflow velocity to early diastolic mitral annular velocity did not differ between the groups. However, paricalcitol treatment significantly reduced intact parathyroid hormone (P,0.001) and alkaline phosphatase (P=0.001) levels as well as the number of cardiovascular-related hospitalizations compared with placebo. In conclusion, 52 weeks of treatment with oral paricalcitol (1 mg one time daily) significantly improved secondary hyperparathyroidism but did not alter measures of LV structure and function in patients with severe CKD.

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confidence: 99%

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD—The OPERA Trial

Wang

Fang

Chan

et al. 2014

Journal of the American Society of Nephrology

222

192

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“…Binding of vitamin D 3 promotes the vitamin D receptor (VDR) to form a heterodimer with the retinoid X receptor and transactivates vitamin D-responsive elements present in target genes (6) . VDR mRNA and protein have previously been detected and studied in several rat tissues including liver (7,8) .Diabetes-associated liver complications are widely studied using STZ-induced diabetic rats (9) . Net glucose uptake and its metabolism in hepatocytes depend on intracellular metabolic status, which is determined by metabolic enzymes, second messengers and transcription factors.…”

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confidence: 99%

Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

George¹,

Kumar

Antony

et al. 2012

Br J Nutr

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Diabetes mellitus is a growing health problem worldwide and is associated with severe liver complications. The aim of the present study is to analyse the status of metabolic and free-radical-scavenging enzymes and second messengers in the liver of streptozotocin (STZ)-induced diabetic rats, and to determine the hepatoprotective role of vitamin D 3 . All studies were performed using the liver of adult male Wistar rats. Gene expression studies were carried out using real-time PCR with specific probes. Second messenger levels were determined using 3 H-labelled Biotrak assay kits, and glucose uptake assay with D-[ 14 C]glucose. The present results show that there was a decrease in hepatic glucose uptake, malate dehydrogenase activity, glycogen content, inositol triphosphate (IP 3 ) and cyclic GMP levels, and superoxide dismutase, glutathione peroxidase, phospholipase C, cyclic AMP-responsive element-binding protein, vitamin D receptor (VDR) and insulin receptor (INSR) gene expression in the diabetic rats when compared with the controls (all P,0·05), while cyclic AMP levels and GLUT2 expression were increased (P,0·05). Treatment of the diabetic rats with vitamin D 3 and insulin reversed the altered parameters to near control values. In conclusion, the data suggest a novel role of vitamin D 3 in restoring impaired liver metabolism in STZ-induced diabetic rats by regulating glucose uptake, storage and metabolism. We demonstrated that the restoring effect of vitamin D 3 is mediated through VDR modulation, thereby improving signal transduction and controlling free radicals in the liver of diabetic rats. These data suggest a potential role for vitamin D 3 in the treatment of diabetes-associated hepatic complications.Key words: Vitamin D: Diabetes: Liver: Oxidative stress: Metabolism: Insulin Diabetes-associated complications are major causes of morbidity and mortality. The liver plays a unique role in glucose homeostasis. Because of its anatomical location, it is ideally suited to control the systemic supply of absorbed nutrients, and it is one of only two organs that both consume and produce substantial amounts of glucose. The central role of the liver in the maintenance of blood glucose levels is assured by complex regulation by metabolic substrates, insulin and other hormones (1) . Diabetes-associated hyperglycaemia and hypoinsulinaemia lead to the impairment of hepatic glucose and lipid metabolism. Virtually, the entire spectrum of liver diseases is seen in patients with diabetes, including liver cirrhosis, a significant cause of death in diabetic patients, even more relevant than CVD (2) . Interest in the development of novel antidiabetic agents has been fuelled by the intense complications due to therapeutic treatment of diabetes and associated liver failure (2,3) . An increased prevalence of diabetes has been observed in vitamin D-deficient individuals (4) , and our previous study has shown that vitamin D 3 treatment restores blood glucose homeostasis in streptozotocin (STZ)-induced diabetic rats (5) . Bind...

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“…These include interaction of calcitriol with a membrane receptor, either a novel receptor or the known vitamin D receptor, thereby activating cell signalling pathways (Nemere and Campbell, 2000;Holick, 2003;Evans et al, 2004;Fleet, 2004;Mizwicki et al, 2004;Dusso et al, 2005;Hendy et al, 2006). There is growing direct evidence that the traditional vitamin D receptor may also have a unique, nontranscriptional role in plasma membrane initiated signalling (Fleet, 2004 (Berger et al, 1988;Sandgren et al, 1991;Rougui et al, 1998;Sheinin et al, 2000;Chatterjee, 2001;Holick, 2003;Lee et al, 2003). The exact roles of calcitriol at all these sites are not always completely understood.…”

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confidence: 99%

“…Vitamin D receptors are also more abundant deep in crypts than in villar cells (Clemens et al, 1988). Results are, however, controversial in some instances (Berger et al, 1988;Sandgren et al, 1991;Kinyamu et al, 1997;Wood et al, 1998;Colin et al, 1999;Sheinin et al, 2000;Leonard et al, 2001;Lee et al, 2003;Pazianas et al, 2003;Chen et al, 2006). …”

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Vitamin D receptor distribution in intestines of domesticated sheep Ovis ammon f. aries

Riner

Boos

Hässig

et al. 2007

Journal of Morphology

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The biologically active form of vitamin D, i.e., 1,25‐dihydroxycholecalciferol or calcitriol, plays an important role in bone metabolism and calcium homeostasis, which is often disturbed at the onset of lactation in high milk‐yielding domestic ruminants. Gene transcription is modulated via vitamin D receptors, but nongenomic effects of vitamin D via membrane receptors have also been described. In the intestines, vitamin D promotes calcium absorption via vitamin D receptors. Vitamin D receptors are of clinical relevance, but have not been systematically assessed within all segments of the intestine in any species. Thus, we present for the first time an immunohistochemical study of the distribution patterns of the vitamin D receptor protein in sheep, which may be the basis for present and future investigations on mineral homeostasis in domestic ruminants. Tissue probes of the intestines were collected from five lambs and five nonlactating and nonpregnant dams, fixed in formalin, embedded in paraffin, and used for the assessment of vitamin D receptor protein. Nuclear vitamin D receptor immunoreaction was scored semiquantitatively and exhibited a segment‐specific distribution pattern. Goblet cells always were devoid of any vitamin D receptor immunoreaction. Surface epithelial cells and enterocytes of the crypt openings generally demonstrated only a weak immunoreaction. Basally and/or intermediately located crypt epithelial cells exhibited stronger immunoreactions in duodenum, jejunum, and colon descendens. This basal/intermediate to superficial gradient was most pronounced in the duodenum and less evident in jejunum and colon descendens and not observed in ileum and cecum. There were no age‐dependent variations in vitamin D receptor protein expression. Results demonstrate that intestinal vitamin D receptor distribution patterns are segment‐specific and strongest immunoreactions correlate with highest intestinal calcium absorptive activities, as reported in literature. Strong expression of vitamin D receptors within the lower half of crypts also suggests a role for calcitriol in epithelial differentiation and cellular homeostasis. J. Morphol., 2008. © 2007 Wiley‐Liss, Inc.

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Tissue distribution of the 1,25-dihydroxyvitamin D3 receptor in the male rat

Cited by 94 publications

References 27 publications

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD—The OPERA Trial

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD—The OPERA Trial

Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

Vitamin D receptor distribution in intestines of domesticated sheep Ovis ammon f. aries

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Tissue distribution of the 1,25-dihydroxyvitamin D3 receptor in the male rat

Cited by 94 publications

References 27 publications

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD—The OPERA Trial

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD—The OPERA Trial

Effect of vitamin D3in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

Vitamin D receptor distribution in intestines of domesticated sheep Ovis ammon f. aries

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Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats