Tissue distribution of human IgG Fc receptors CD16, CD32 and CD64: An immunohistochemical study

Tuijnman, Wouter B.; Wichen, D.F. van; Schuurman, Henk‐Jan

doi:10.1111/j.1699-0463.1993.tb00117.x

Cited by 38 publications

(30 citation statements)

References 37 publications

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“…Similar to human lymphoid tissues, immunostaining for CD32 was limited mainly to the mantle zone of the follicles suggesting that not all the IgM + cells express CD32 (Tuijnman et al, 1993). This finding correlates with flow cytometry data showing that only 75% to 83% of IgM + cells express CD32 in newborn and older calves (Chattha et al, 2010b).…”

Section: Discussionsupporting

confidence: 82%

Immunohistochemical investigation of cells expressing CD21, membrane IgM, CD32 and a follicular dendritic cell marker in the lymphoid tissues of neonatal calves

Chattha

Hodgins

Delay

et al. 2010

Veterinary Immunology and Immunopathology

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a b s t r a c tActivation of B lymphocytes in the presence of passive maternal antibodies depends on expression of CD21, membrane IgM and CD32. On colligation with IgM, CD32 inhibits activation whereas CD21 enhances it. Recently, we assessed expression of CD21 and CD32 on IgM + cells from lymphoid tissues of newborn calves by flow cytometry, but this approach does not provide information about spatial distribution within lymphoid compartments. Therefore, histologic sections of lymphoid tissues from newborn and 7-month-old calves were examined using an immunoperoxidase technique. In all calves, CD21 and IgM stained cells were collocated in the cortex and paracortex of the retropharyngeal lymph node, in the marginal zone of the spleen and in lymphoid aggregates of palatine tonsils. Most CD32 + cells were in the mantle zone of lymphoid follicles in 7-month-old calves, whereas only weak staining was observed in newborns. A few CD32 + cells were also observed in the paracortex at both ages. Absence of CD32 + cells in the center of follicles suggests that IgM + CD32 − cells observed previously by flow cytometry were from germinal centers. Overall, there were few organized lymphoid aggregates within lymphoid tissues of newborn calves, and follicular dendritic cells were virtually undetectable. Their absence may be an important limitation for neonatal immunization.

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Section: Discussionsupporting

confidence: 82%

Immunohistochemical investigation of cells expressing CD21, membrane IgM, CD32 and a follicular dendritic cell marker in the lymphoid tissues of neonatal calves

Chattha

Hodgins

Delay

et al. 2010

Veterinary Immunology and Immunopathology

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“…There are few reports of FcgRIII expression by macrophages in other normal tissues. The clearest evidence relates to Kuppfer cells, alveolar macrophages, and a small minority of monocytes [12,13]. Cells within lymphoid tissue, bone marrow and placenta express FcgRIII, but at least a proportion of these are likely to be NK cells.…”

Section: Discussionmentioning

confidence: 99%

“…Information on the distribution of FcgRIIIa expression by macrophages in other normal tissues is conflicting. Kuppfer cells and alveolar macrophages show expression, but in many other tissues FcgRIIIa expression appears to be absent or limited to a few scattered cells [12]. In one study [13], FcgRIIIa was rarely found in tissues not containing tumours.…”

Section: Introductionmentioning

confidence: 99%

Restricted expression of FcγRIII (CD16) in synovium and dermis: implications for tissue targeting in rheumatoid arthritis (RA)

Edwards

Blades

Cambridge

1997

Clinical and Experimental Immunology

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Interactions between immune complexes and immunoglobulin Fc receptors may contribute to inflammation in RA. Previous studies suggested that FcγRIII (CD16) may be preferentially expressed in diseased synovial intima. The distribution of immunoreactive FcγRIII was examined in normal fetal limb tissues, and both normal and selected abnormal samples of adult synovium and skin. In fetal limbs at 10–14 weeks gestation FcγRIII was restricted to synovial intima. In normal adult synovium FcγRIII was restricted to intimal cells. In inflamed synovia differential expression of FcγRIII in the intima was less consistent. In both fetal and adult synovium FcγRIII was largely restricted to cells expressing CD45 (leucocyte common antigen). Staining for FcγRIII was, however, occasionally associated with CD45− intimal cells in fetal synovium. In both fetal and adult tissues cell membrane FcγRIII was frequently closely associated with complement decay‐accelerating factor (DAF), which is present on intimal fibroblasts and extracellular matrix. FcγRIII expression was minimal in normal forearm dermis, but widespread on CD45+ cells in skin exposed to mechanical stress. In skin containing rheumatoid nodules, FcγRIII was preferentially expressed on palisading macrophages. These observations indicate that expression of FcγRIII on macrophages may be involved in the susceptibility of connective tissues to immune complex‐induced damage in RA. Colocalization of FcγRIII and DAF in synovium may indicate an unrecognized functional interrelationship.

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“…17 Another study using immunohistochemistry suggested that FcgRI, FcgRII, and FcgRIII all are present on macrophages of the spleen. 18 These studies could not distinguish between the isoforms of FcgRII and FcgRIII.…”

mentioning

confidence: 90%

Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors

et al. 2018

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Tissue distribution of human IgG Fc receptors CD16, CD32 and CD64: An immunohistochemical study

Cited by 38 publications

References 37 publications

Immunohistochemical investigation of cells expressing CD21, membrane IgM, CD32 and a follicular dendritic cell marker in the lymphoid tissues of neonatal calves

Immunohistochemical investigation of cells expressing CD21, membrane IgM, CD32 and a follicular dendritic cell marker in the lymphoid tissues of neonatal calves

Restricted expression of FcγRIII (CD16) in synovium and dermis: implications for tissue targeting in rheumatoid arthritis (RA)

Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors

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