Tissue distribution of drug-metabolizing enzymes in humans

Conjugation pathways in liver disease.

“…Thus, the in vivo glucuronidating capacity of those patients whose functional hepatic parenchyma is much less may be limited. The recovery of microsomal protein from normal liver reported in this study accords with that described previously (Pacifici et al, 1988e).…”

Conjugation pathways in liver disease.

“…Thus, the in vivo glucuronidating capacity of those patients whose functional hepatic parenchyma is much less may be limited. The recovery of microsomal protein from normal liver reported in this study accords with that described previously (Pacifici et al, 1988e).…”

Profile of Drug-Metabolizing Enzymes in Human Ileum and Colon

“…We have previously reported on the ethoxycoumarin O-deethylase, microsomal epoxide hydrolase, glucuronyltransferase, sulphotransferase and acetyltransferase in human gut [17]. The present results are in accordance with those published.…”

Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer

“…This may be attributed to multifactorial role of the GSTT1, both activation and detoxification process, expression of GSTT1 in red blood cells resulting in more generalized detoxification process[ 9 ] and expression of GSTT1 in the squamous mucosa of the head and neck. [ 71 72 73 ] In the present meta-analysis, GSTT1 null genotype was a significant risk factor for OC, in line with meta-analysis of esophageal cancers,[ 37 ] prostate cancer,[ 38 ] breast cancer[ 77 ] and OC. [ 15 ]…”

Conjugation pathways in liver disease.

“…Thus, the in vivo glucuronidating capacity of those patients whose functional hepatic parenchyma is much less may be limited. The recovery of microsomal protein from normal liver reported in this study accords with that described previously (Pacifici et al, 1988e).…”

Profile of Drug-Metabolizing Enzymes in Human Ileum and Colon

“…We have previously reported on the ethoxycoumarin O-deethylase, microsomal epoxide hydrolase, glucuronyltransferase, sulphotransferase and acetyltransferase in human gut [17]. The present results are in accordance with those published.…”

Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer

“…This may be attributed to multifactorial role of the GSTT1, both activation and detoxification process, expression of GSTT1 in red blood cells resulting in more generalized detoxification process[ 9 ] and expression of GSTT1 in the squamous mucosa of the head and neck. [ 71 72 73 ] In the present meta-analysis, GSTT1 null genotype was a significant risk factor for OC, in line with meta-analysis of esophageal cancers,[ 37 ] prostate cancer,[ 38 ] breast cancer[ 77 ] and OC. [ 15 ]…”

Conjugation pathways in liver disease.

“…Thus, the in vivo glucuronidating capacity of those patients whose functional hepatic parenchyma is much less may be limited. The recovery of microsomal protein from normal liver reported in this study accords with that described previously (Pacifici et al, 1988e).…”

Profile of Drug-Metabolizing Enzymes in Human Ileum and Colon

“…We have previously reported on the ethoxycoumarin O-deethylase, microsomal epoxide hydrolase, glucuronyltransferase, sulphotransferase and acetyltransferase in human gut [17]. The present results are in accordance with those published.…”

Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer

“…This may be attributed to multifactorial role of the GSTT1, both activation and detoxification process, expression of GSTT1 in red blood cells resulting in more generalized detoxification process[ 9 ] and expression of GSTT1 in the squamous mucosa of the head and neck. [ 71 72 73 ] In the present meta-analysis, GSTT1 null genotype was a significant risk factor for OC, in line with meta-analysis of esophageal cancers,[ 37 ] prostate cancer,[ 38 ] breast cancer[ 77 ] and OC. [ 15 ]…”