Tissue Distribution and Whole Body Burden of the Chlorinated Polyfluoroalkyl Ether Sulfonic Acid F-53B in Crucian Carp (<i>Carassius carassius</i>): Evidence for a Highly Bioaccumulative Contaminant of Emerging Concern

Shi, Yunfeng; Vestergren, Robin; Zhou, Zhen; Song, Xiaowei; Xu, Lin; Liang, Yong; Cai, Yaqi

doi:10.1021/acs.est.5b04299

Cited by 195 publications

(187 citation statements)

References 53 publications

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“…Given the lack of mammalian toxicokinetic data for Cl-PFESAs, it was assumed that PFOS and C8 Cl-PFESA have the same V d (230 mL/kg) 37 based on their similar blood/tissue distribution ratios in crucian carp. 30 Exposure Mass-Balance and Calculation of Total Elimination Half-Lives. In order to estimate total elimination half-lives by all routes of excretion, a one-compartment model was used to establish a mass-balance of C8 Cl-PFESA and PFOS in high fish consumers.…”

Section: ■ Methodsmentioning

confidence: 99%

“…28,29 In a proceeding paper, we provided the first evidence for efficient uptake and accumulation of F-53B in crucian carp under natural conditions. 30 Combined with widespread contamination of surface water, 28 sewage sludge 29 and fish samples 30 from China we postulated that Cl-PFESAs could make a significant contribution to the body burden of PFASs in humans.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The lack of a clear trend between Cl-PFESAs in serum and length of employment at the fishery may be explained by the fact that many individuals in this group reported a high fish consumption prior to starting their job at the fishery. Since the fish from Tangxun Lake was found to contain similar or lower concentrations of Cl-PFESAs compared to other parts of China, 30 it is possible the majority of fishery employees have had a similar dietary exposure for a long time. Thus, the lack of a clear trend with duration of exposure indicates that the serum concentrations in fishery employees with >1 years of employment may be close to a steady-state.…”

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confidence: 99%

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Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)

Shi

Vestergren

et al. 2016

Environ. Sci. Technol.

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ABSTRACT:The incomplete mass-balance of organic fluorine in human serum indicates the existence of unknown per-and polyfluoroalkyl substances (PFASs) with persistent and bioaccumulative properties. Here we characterized human exposure and elimination kinetics of chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) in metal plating workers (n = 19), high fish consumers (n = 45), and background controls (n = 8). Cl-PFESAs were detected in >98% of the sampled individuals with serum concentrations ranging <0.019−5040 ng/mL. Statistically higher median serum levels were observed in high fish consumers (93.7 ng/mL) and metal plating workers (51.5 ng/mL) compared to the background control group (4.78 ng/mL) (Kruskal−Wallis rank sum test, p < 0.01). Cl-PFESAs could account for 0.269 to 93.3% of ∑PFASs in human serum indicating that this compound class may explain a substantial fraction of previously unidentified organic fluorine in the Chinese population. Estimated half-lives for renal clearance (median 280 years; range 7.1−4230 years) and total elimination (median 15.3 years; range 10.1−56.4 years) for the eight carbon Cl-PFESA suggest that this is the most biopersistent PFAS in humans reported to date. The apparent ubiquitous distribution and slow elimination kinetics in humans underscore the need for more research and regulatory actions on Cl-PFESAs and PFAS alternatives with similar chemical structures.

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Section: ■ Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)

Shi

Vestergren

et al. 2016

Environ. Sci. Technol.

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232

167

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“…33 Muscle samples were processed using an alkaline digestion method, 34 whereas homogenates of whole fish and other tissue samples were extracted with the ion-pairing liquid extraction method using tetra-n-butyl ammonium hydrogen sulfate (TBA) and methyl tert-butyl ether (MTBE). 34 Instrumental analysis was accomplished using a high performance liquid chromatography (Ultimate 3000 HPLC, Thermo Fisher Scientific Co.) equipped with an electrospray ionization tandem mass spectrometer (ESI-MS/MS, API 4500, Applied Biosystems/MDS SCIEX, USA) operated in negative mode. Two different chromatographic systems were tested for effective separation of cyclic PFASs using (i) an Acclaim 120 C18 Column (5 μm, 4.6 mm × 150 mm, ThermoFisher Scientific Co.) and (ii) an ACQUITY HSS PFP Column (1.8 μ m, 100 Å, 5 cm × 2.1 mm, Waters Co.), respectively.…”

Section: Environmental Science and Technologymentioning

confidence: 99%

Identification, Tissue Distribution, and Bioaccumulation Potential of Cyclic Perfluorinated Sulfonic Acids Isomers in an Airport Impacted Ecosystem

Wang

Vestergren

Shi

et al. 2016

Environ. Sci. Technol.

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The use of cyclic perfluoroalkyl acids as anticorrosive agents in hydraulic fluids remains a poorly characterized source of organofluorine compounds to the environment. Here, we investigated the presence of perfluoroethylenecyclohexanesulfonate (PFECHS) isomers in environmental samples for the first time using a combination of high resolution and tandem mass spectrometry. Five distinct peaks attributed to different isomers of PFECHS and perfluoropropylcyclopentanesulfonate (PFPCPeS) were identified in environmental samples. The sum of PFECHS and PFPCPeS isomers displayed logarithmically decreasing spatial trends in water (1.04−324 ng/L) and sediment samples (

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“…These compounds have been produced and used for many different industrial and commercial applications, such as textiles, paper packaging, carpets, pesticides, surfactants, polymer additives and fire-fighting foams, since the 1950s [1][2][3]. PFASs have been detected in human serum [4][5][6], milk [7], and urine [8].…”

Section: Introductionmentioning

confidence: 99%

A rapid and fully automatic method for the accurate determination of a wide carbon-chain range of per- and polyfluoroalkyl substances (C4–C18) in human serum

Gao

et al. 2016

Journal of Chromatography A

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a b s t r a c tA rapid and fully automatic method for determining 21 per-and polyfluoroalkyl substances (with carbon chains ranging from C4 to C18, including 13 PFCAs, 5 PFSAs, 2 Cl-PFESAs, and PFOSA) in human serum samples was developed. The HPLC parameters, Turboflow column, mobile phase, sample injection volume, loading flow rate, and sample cleanup and elution time were optimized. 25 L serum sample was directly injected into the developed on-line Turboflow SPE HPLC-MS/MS system for analysis after dilution. Matrix effects were corrected due to the matrix removal efficiency of the Turboflow column and sufficient types of internal isotope standards that were used. The established method showed a good linearity (r 2 > 0.99), rapid processing time (20 min per sample), satisfactory recoveries (matrix spiked recoveries range from 84.6% to 114%) and precision (intra-day and inter-day RSDs ranged from 1.5% to 9.2% and from 1.1% to 7.0%, respectively). The limits of detection (LODs) of the 21 analyzed PFASs were between 0.008 and 0.19 ng mL −1 . The LODs of short-and long-chain PFASs, such as PFBA, PFPeA, PFHxDA, and PFODA, were 0.008, 0.022, 0.15 and 0.19 ng mL −1 , respectively; the spiked recoveries of these PFASs were 101, 105, 87.1, and 85.8%, respectively. Both the LODs and recoveries were better than previous studies. Further, serum PFASs concentrations detected by the presented on-line SPE method were consistent with the traditional off-line SPE method (r: 0.98-0.99), which verified the accuracy and applicability of the present method. The method shows good practical prospects in the analysis of trace per-and polyfluoroalkyl substances in human serum.

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Tissue Distribution and Whole Body Burden of the Chlorinated Polyfluoroalkyl Ether Sulfonic Acid F-53B in Crucian Carp (Carassius carassius): Evidence for a Highly Bioaccumulative Contaminant of Emerging Concern

Cited by 195 publications

References 53 publications

Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)

Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)

Identification, Tissue Distribution, and Bioaccumulation Potential of Cyclic Perfluorinated Sulfonic Acids Isomers in an Airport Impacted Ecosystem

A rapid and fully automatic method for the accurate determination of a wide carbon-chain range of per- and polyfluoroalkyl substances (C4–C18) in human serum

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