Tissue distribution and functional analysis of vitellogenin-6 of Toxocara canis

Zhu, Hong-Hong; Ma, Guangxu; Luo, Yong-Fang; Luo, Yongli; Yin, Shasha; Xiong, Yi; Zhou, Rongqiong

doi:10.1016/j.exppara.2017.03.009

Cited by 6 publications

(3 citation statements)

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“…Vitellogenin (Vg), recognized as a reservoir of both amino acids and lipids within the eggs of the parasites, is acknowledged to hold a pivotal role in the embryonic development of a diverse spectrum of organisms. A recent study focused on quantifying the transcription levels of the Tc-vit-6 gene in adult male and female T. canis using quantitative real-time PCR revealed a significant transcription of the Tc-vit-6 gene in specific anatomical regions, including the intestines, reproductive tract, and body wall of both male and female T. canis, highlighting the multifaceted roles of TcVg6 in T. canis, extending beyond its involvement in the reproductive processes of the parasite [235] and making it a potential future point of research in the diagnosis of toxocariasis.…”

Section: Diagnosis Of Toxocariasis In Humansmentioning

confidence: 99%

Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection

Henke,

Ntovas,

Xourgia

et al. 2023

IJERPH

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Toxocariasis remains an important neglected parasitic infection representing one of the most common zoonotic infections caused by the parasite Toxocara canis or, less frequently, by Toxocara cati. The epidemiology of the disease is complex due to its transmission route by accidental ingestion of embryonated Toxocara eggs or larvae from tissues from domestic or wild paratenic hosts. Even though the World Health Organization and Centers for Disease Control classified toxocariasis amongst the top six parasitic infections of priority to public health, global epidemiological data regarding the relationship between seropositivity and toxocariasis is limited. Although the vast majority of the infected individuals remain asymptomatic or experience a mild disease, the infection is associated with important health and socioeconomic consequences, particularly in underprivileged, tropical, and subtropical areas. Toxocariasis is a disease with multiple clinical presentations, which are classified into five distinct forms: the classical visceral larva migrans, ocular toxocariasis, common toxocariasis, covert toxocariasis, and cerebral toxocariasis or neurotoxocariasis. Anthelmintic agents, for example, albendazole or mebendazole, are the recommended treatment, whereas a combination with topical or systemic corticosteroids for specific forms is suggested. Prevention strategies include educational programs, behavioral and hygienic changes, enhancement of the role of veterinarians, and anthelmintic regimens to control active infections.

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Section: Diagnosis Of Toxocariasis In Humansmentioning

confidence: 99%

Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection

Henke,

Ntovas,

Xourgia

et al. 2023

IJERPH

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“…Vg is a major precursor of vitellins, which are egg yolk proteins that provide energy reserves for embryonic development in oviparous organisms (Matozzo et al 2008). To date, six Vg genes (1 to 6) have been identified in the nematode Caenorhabditis elegans (Boag et al 2001), and a female-specific Vg-6 has been identified in Haemonchus contortus (Hartman et al 2001), Trichostrongylus vitrines (Nisbet and Gasser 2004), and Toxocara canis (Zhu et al 2017). These Vg genes play roles in reproduction and may be involved in adult biological processes (Zhu et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Role of the insulin-like growth factor system in gonad sexual maturation in Pacific oyster Crassostrea gigas

Moon

Choi

2020

Fish Aquatic Sci

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Background: The IGF system plays important roles in controlling growth, development, reproduction, and aging of organisms. Methods: To estimate maturation of the Pacific oyster Crassostrea gigas, we investigated the expression of insulinlike growth factor (IGF) system components and sex-specific genes. To determine the role of the IGF system in the growth and spawning period of female and male oysters, we examined mRNA expression levels of the C. gigas insulin receptor-related receptor (CIR), IGF binding protein complex acid labile subunit (IGFBP_ALS), and molluscan insulin-related peptide (MIP), as well as those of vitellogenin (Vg) and receptor-type guanylate cyclase (Gyc76C) in gonads of C. gigas collected between April and October, when sex can be determined visually in this species. Results: We found that MIP, IGFBP_ALS, and CIR mRNA expression levels were dependent on sex and month and were greater in males than in females. CIR and Vg mRNA expression levels were very similar among females, whereas IGF system components and Gyc76C were very similarly expressed among males. The highest expression values were observed in May, when oysters are mature; CIR and Vg mRNA expression levels were highest in females, and those of MIP, IGFBP_ALS, CIR, and Gyc76C were highest in males. Interestingly, we observed a 1:1 proportion of females to males during this period. Conclusion: Our results suggest that IGF system components, as well as Vg and Gyc76C, are associated with sexual maturation in C. gigas.

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“…Caenorhabditis elegans has been the primary model for investigating vitellogenin in nematodes; however, orthologous genes have been found in other free-living nematodes, Oscheius tipulae (Almenara et al, 2013) and C. briggsase (Zucker-Aprison & Blumenthal, 1989). Vitellogenin has also been identified in the animalparasitic nematodes Toxocara canis (Zhu et al, 2017), Haemonchus contortus (Hartman et al, 2001) and Trichostrongylus vitrinus (Nisbet & Gasser, 2004). In Heterodera glycines, vitellogenin has been described and partially characterised as two major egg proteins (Masler, 1999).…”

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confidence: 99%

Comparative phylogenetic analysis of vitellogenin in species of cyst and root-knot nematodes

2023

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Summary Plant-parasitic nematodes (PPN) are an economically important group of crop pests and are oviparous animals; all nutrients required to develop and ensure the survival of their unhatched progeny need to be deposited within the egg, including proteins. The most abundant protein deposited is vitellin, formed of a precursor protein vitellogenin, which has roles in transporting lipids, providing amino acids and influencing post-embryonic development. The genes encoding vitellogenin have been well studied in Caenorhabditis elegans, but little is known about vitellogenin in PPN. Using the vitellogenin gene sequences from C. elegans, homologous sequences in the genomes of some economically important cyst and root-knot nematodes were identified and hypothetical vitellogenin genes were predicted. Protein domains were then determined. Sequences were aligned using MUSCLE and then used to construct phylogenetic trees using the maximum likelihood method. With the availability of genomic data and use of online local alignment tools, the vitellogenin encoding genes from C. elegans could be aligned to PPN genomes. All predicted genes contained the same protein domains as C. elegans; Vitellogenin_N, vitellogenin open beta-sheet and von Willebrand factor domain type D. The constructed phylogenetic tree clustered the species into four groups: root-knot nematodes, two cyst nematode groups and Caenorhabditis species. By determining the hypothetical vitellogenin genes in PPN and inferring their relationships, this could form a potential basis to understand further the role of vitellogenin in cyst and root-knot nematodes.

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Tissue distribution and functional analysis of vitellogenin-6 of Toxocara canis

Cited by 6 publications

References 50 publications

Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection

Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection

Role of the insulin-like growth factor system in gonad sexual maturation in Pacific oyster Crassostrea gigas

Comparative phylogenetic analysis of vitellogenin in species of cyst and root-knot nematodes

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