Tissue Destruction Following Cold Coagulation of the Cervix

Haddad, Nabil F.; Hussein, I. Y.; Blessing, K.; Kerr-Wilson, R.; Smart, G. E.

doi:10.1089/gyn.1988.4.23

Cited by 17 publications

(11 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cold coagulation is indicated for non‐pregnant women of any age with CIN1‐3 when the entire transformation zone is visible, when there is no suspicion of endocervical involvement or of micro‐invasive, invasive, or glandular disease, and when the transformation zone has not previously been treated . The procedure is fast (20–45 seconds per application) and achieves a treatment depth of 4–7 mm . Anaesthesia can be avoided in most patients, and complications and adverse effects are minimal .…”

Section: Introductionmentioning

confidence: 99%

Meta‐analysis of the efficacy of cold coagulation as a treatment method for cervical intraepithelial neoplasia: a systematic review

Dolman

Sauvaget

Muwonge

et al. 2014

BJOG

105

123

View full text Add to dashboard Cite

Background Cold coagulation is an ablative method for treatment of cervical intraepithelial neoplasia (CIN). Despite reports of efficacy against all grades of CIN (CIN1-3), cold coagulation has been infrequently used since the 1980s, and was absent from the recent Cochrane review on CIN treatment.Objectives To provide a systematic review of cold coagulation efficacy and acceptability for CIN treatment through meta-analysis of clinical reports and a randomised control trial.Search strategy A literature search in PubMed, Web of Science, EMBASE, and regional databases yielded 388 papers. Title, abstract and/or reference list review identified 22 papers describing cold coagulation treatment of CIN, with 13 providing adequate data for inclusion in the meta-analysis.Selection criteria Publications or conference abstracts describing original data (number of women treated, followed up and cured, provider type, cure definition) were retained. No language or publication date limitations were imposed.Data collection and analysis Data extracted from 13 studies were pooled, and statistical analyses of proportion cured were conducted with data stratified by lesion grade and study region.Main results Among 4569 CIN patients treated with cold coagulation, summary proportion cured of 96% [95% confidence interval (CI) 92-99%] and 95% (92-98%) were obtained for CIN1 and CIN2-3 disease, respectively. Side-effects and adverse effects were infrequent, and fertility was not impaired.Conclusions Cold coagulation CIN cure rates were comparable to those of other excisional and ablative methods. Cold coagulation is indicated for all grades of CIN, is safe, quick and acceptable, and may be of particular relevance for use in resource-limited settings.

show abstract

Section: Introductionmentioning

confidence: 99%

Meta‐analysis of the efficacy of cold coagulation as a treatment method for cervical intraepithelial neoplasia: a systematic review

Dolman

Sauvaget

Muwonge

et al. 2014

BJOG

105

123

View full text Add to dashboard Cite

show abstract

“…(1988) showed that the depth of destruction ranged from 2.5 mm to 4 mm or more after treatment at 100°C for 30s and always cxcceded 4 mm after treatment at 120°C for 30s. Haddad et al (1988) found that the mean depth of tissue destruction ranged from 2-6 mm (100°C for 20 s) to 3.5 mm (120°C for 30 s).…”

Section: Discussionmentioning

confidence: 99%

Effective destruction of cervical intraepithelial neoplasia (CIN) 3 at 100°C using the Semm cold coagulator: 14 years experience

Gordon¹,

Duncan²

1991

International Journal of Gynecology & Obstetrics

View full text Add to dashboard Cite

A total of 1628 women with CIN 3 treated with the Semm cold coagulator between 1975 and 1989 was followed primarily by cytology. The standard suitability criteria for ablation were adhered to except that patients were treated at their first visit when the colposcopist expected that the diagnosis would be no worse than CIN 3. Overall 97% of the women were treated at their first visit. In 30 women (2%) the histology was glandular or worse than expected, but 22 of these showed no persistent cervical disease subsequently. Follow-up was achieved for 87% at 10 years. In actuarial terms the primary success rate was 95% at 1 year and 92% at 5 years, it was similar for all age groups. Repeat coldcoagulation for persistenthecurrent CIN 3 was less successful and is not advised. The outcome for 226 pregnancies established after treatment is known. The rates for miscarriage, preterm or operative delivery were not increased. Cold-coagulation of CIN 3 at 100°C as performed by us is as effective as any other treatment and calls into question the need for more expensive practices.

show abstract

“…De Cristofaro et al . (1988) showed that the depth of destruction ranged from 2.5 mm to 4 mm or more after treatment at 100°C for 30s and always exceeded 4 mm after treatment at 120°C for 30 s. Haddad et al . (1988) found that the mean depth of tissue destruction ranged from 2.6 mm (100°C for 20s) to 3.5 mm (120°C for 30s).…”

Section: Discussionmentioning

confidence: 99%

Effective destruction of cervical intraepithelial neoplasia (CIN) 3 at 100°C using the Semm cold coagulator: 14 years experience

Gordon

Duncan

1991

BJOG

View full text Add to dashboard Cite

Summary. A total of 1628 women with CIN 3 treated with the Semm cold coagulator between 1975 and 1989 was followed primarily by cytology. The standard suitability criteria for ablation were adhered to except that patients were treated at their first visit when the colposcopist expected that the diagnosis would be no worse than CIN 3. Overall 97% of the women were treated at their first visit. In 30 women (2%) the histology was glandular or worse than expected, but 22 of these showed no persistent cervical disease subsequently. Follow‐up was achieved for 87% at 10 years. In actuarial terms the primary success rate was 95% at 1 year and 92% at 5 years, it was similar for all age groups. Repeat coldcoagulation for persistent/recurrent CIN 3 was less successful and is not advised. The outcome for 226 pregnancies established after treatment is known. The rates for miscarriage, preterm or operative delivery were not increased. Cold‐coagulation of CIN 3 at 100°C as performed by us is as effective as any other treatment and calls into question the need for more expensive practices.

show abstract

Tissue Destruction Following Cold Coagulation of the Cervix

Cited by 17 publications

References 4 publications

Meta‐analysis of the efficacy of cold coagulation as a treatment method for cervical intraepithelial neoplasia: a systematic review

Meta‐analysis of the efficacy of cold coagulation as a treatment method for cervical intraepithelial neoplasia: a systematic review

Effective destruction of cervical intraepithelial neoplasia (CIN) 3 at 100°C using the Semm cold coagulator: 14 years experience

Effective destruction of cervical intraepithelial neoplasia (CIN) 3 at 100°C using the Semm cold coagulator: 14 years experience

Contact Info

Product

Resources

About