Tissue Damage in Cattle Infected withTheileria annulataAccompanied by Metastasis of Cytokine-producing, Schizont-infected Mononuclear Phagocytes

Forsyth, L.M.G.; Minns, Fiona; Kirvar, E.; Adamson, Rachel; Hall, Franklin R.; McOrist, S.; Brown, C.G.D.; Preston, Patricia M.

doi:10.1053/jcpa.1998.0256

Cited by 95 publications

(75 citation statements)

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“…According to previous studies, schizont-infected cells may disseminate through the lymphoid tissues into pituitary and thyroid glands and cause injury and reduce their secretions (Forsyth et al, 1999). It has been reported that following experimental infection with T. annulata, thyroid hormones decreased significantly (Garg et al, 2001;Khalil et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Razavi¹,

Moghaddas²,

Rakhshande³

et al. 2015

Research J. of Parasitology

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Tropical theileriosis of cattle is a common tick-borne disease in tropical and subtropical regions and is recognized as a disease of major economic importance. This study aimed to determine whether Theileria annulata infection influences the plasma homocystein (Hcy), thyroid activity and serum lipid status in infected cattle. Fifty crossbred Holstein cattle, naturally infected with Theileria annulata were selected and divided into 3 subgroups according to their parasitemia rates (<2, 2-4, 4-8%). Also, 10 non-infected cattle were assigned as controls. Blood samples were collected and hematological parameters, plasma Homocystein (Hcy), thyroid hormones (T 3 , T 4 , free T3 (fT 3 ) and free T 4 (fT 4 )) and the concentrations of serum lipid and lipoproteins (cholesterol, triglyceride and lipoproteins including HDL, LDL and VLDL cholesterol) and phosphatidylserine (PS) on erythrocytes were measured. According to the results, significant elevations were observed in the concentration of plasma Hcy (hyperhomocysteinemia) in the infected groups compared to controls. In addition, we conclude that T. annulata can interfere with the lipid metabolism, which is particularly characterized by substantial decreases in the levels of cholesterol, LDL and HDL in the serum of affected animals. In spite of remarkable influences of the parasite on Hcy and lipid contents of the serum, our study proved that tropical theileriosis did not affect the thyroid hormones during parasitemia. This study demonstrates that the infection of cattle with Theileria annulata is mainly characterized by the anemia. Also, evidenced elevation in the level of homocystein (hyperhomocysteinemia) in parasitized cattle can result in oxidative stress on erythrocytes and the probable endothelial injuries. In addition, T. annulata can induce failure in lipid metabolism which is particularly featured by a decrease in the cholesterol, LDL-cholesterol and HDL-cholesterol concentrations; however the parasite cannot implement significant influences on the thyroid hormones in the affected cattle.

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Section: Discussionmentioning

confidence: 99%

“…In cattle with tropical theileriosis, some reports stated that schizont-infected cells may disseminate through the lymphoid tissues into pituitary and thyroid glands and cause injury (Forsyth et al, 1999). Moreover, the thyroid metabolism may deteriorate as a result of the decrease in oxygen transport due to anemia (Issi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Razavi¹,

Moghaddas²,

Rakhshande³

et al. 2015

Research J. of Parasitology

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“…TNF-a and IL-2 could play a role in the pathogenesis of Theileria infections by promoting the proliferation of macroschizont-infected cells and the associated lymphoid hyperplasia (Preston et al 1992). The ulcerative lesions associated with tropical theleriosis may be due to this proinflammatory cytokines (Forsyth et al 1999). It has also been stated that the clinical symptoms of tropical theleriosis (anorexia, pyrexia, cachexia and anaemia) are characteristic of those induced by TNF-a.…”

Section: Discussionmentioning

confidence: 99%

Molecular and pathological studies on natural cases of bovine theileriosis

Gupta

Leishangthem

et al. 2016

J Parasit Dis

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The present communication is a part of study conducted on 32 cases of bovine lymphadenopathies. Out of which, six cases of bovine theileriosis were diagnosed on the basis of peripheral blood smear examination and gross lesions in lymph nodes and visceral organs. Nested PCR using two primer sets N516/N517 and 14136/294 was conducted on samples collected from affected lymph nodes confirms Theileria annulata infection in five out of six cases. Sequencing analysis of amplified product showed 92, 94 and 93 % homology of isolate TH1_Bovine, TH2_Bovine and THEN_Bovine for T. annulata with T.

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“…Sandhu et al (1998) reported an increase in BUN and uric acid in calves infested with theileria, with focal to diffuse coagulative necrosis, severe damage to collecting tubules, haemorrhages and lymphoid aggregations in interstitial spaces. It has also been stated that parasitized lymphoid cells can infect non-lymphoid organs such as liver and kidney inducing tissues damage (Forsyth et al 1999). …”

Section: Discussionmentioning

confidence: 99%

“…Later, the merozoites invade red blood cells. It is followed by the development of piroplasms in erythrocytes, and these intraerythrocyte piroplasms become available to the vector (Campbell and Spooner 1999;Forsyth et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Studying the correlations among hematological and serum biochemical constituents in cattle theileriosis

Ellah

2013

J Parasit Dis

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The present study was undertaken to investigate the influence of tropical theileriosis on serum constituents, erythrocytes and platelets pictures and to study the correlation between the studied parameters. A total number of 26 cows were subjected to study. Out of them 16 cows were suffered from theileria infection. Comparing theileria infected group with the control group revealed significant decreases in total RBCS counts (p \ 0.01), haemoglobin concentration (p \ 0.01), packed cell volume (PCV) (p \ 0.01), platelets count (PLT) (p \ 0.01), plateletcrit (PCT) (p \ 0.01), significant decreases in serum total proteins (p \ 0.01), albumin (p \ 0.01), calcium (p \ 0.01), and phosphorus (p \ 0.01) levels, and significant increases in serum blood urea nitrogen (BUN) (p \ 0.05) and creatinine (p \ 0.05) levels, and in serum aspartate aminotransferase (p \ 0.01) and gamma glutamyl transferase (GGT) (p \ 0.01) activities. Correlations between serum biochemical parameters revealed significant positive correlations between total proteins and albumin (r = 0.598*), A/G ratio and albumin (r = 0.860**), calcium and albumin (r = 0.729*), calcium and A/G ratio (r = 0.752*), GGT and BUN (r = 0.539*), and significant negative correlations between A/G ratio and globulins (r = -0.809**) and between glucose and albumin (r = -0.614*). Erythrocytes count showed a significant negative correlation with mean corpuscular volume (MCV) (r = -0.966**) and red blood cells distribution width (RDW) (r = -0.909**). MCV showed a significant positive correlation with RDW (r = 0.860*) and PCV (r = 0.781*). RDW was positively correlated with PCV (r = 0.966**). PLT count showed a significant positive correlation with mean platelet volume (MPV) (r = 0.992**), platelets distribution width (PDW) (r = 0.956**) and PCT (r = 0.994**). Furthermore, MPV showed a significant positive correlation with PDW (r = 0.940**) and a negative correlation with PCT (r = -0.974**). PDW was negatively correlated with PCT (r = -0.974**). It could be concluded that theileria infection in cattle resulted in mia, thrombocytopenia, hypoproteinaemia, hypoalbuminaemia and hypophosphataemia, in addition to hepatic and kidney dysfunction.

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Tissue Damage in Cattle Infected withTheileria annulataAccompanied by Metastasis of Cytokine-producing, Schizont-infected Mononuclear Phagocytes

Cited by 95 publications

References 0 publications

Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Molecular and pathological studies on natural cases of bovine theileriosis

Studying the correlations among hematological and serum biochemical constituents in cattle theileriosis

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