Tissue concentrations of sulfamethazine and tetracycline hydrochloride of swine ( Sus scrofa domestica ) as it relates to withdrawal methods for international export

Mason, Sharon E.; Wu, Huali; Yeatts, Jim; Baynes, Ronald E.

doi:10.1016/j.yrtph.2015.02.013

Cited by 7 publications

(3 citation statements)

References 14 publications

(17 reference statements)

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“…Extra-label drug use (ELDU) refers to the use of an approved drug in a manner that is not in accordance with the approved label directions. It occurs when a drug only approved for human use is used in animals when a drug approved for one species of animal is used in another, when a drug is used to treat a condition for which it was not approved, or the use of drugs at levels in excess of recommended doses [12]. For instance, the use of enrofoxacin solution as a topical ear medication (only approved for use as an injection) is the common ELDU in veterinary medicine [13].…”

Section: Extra-label Drugmentioning

confidence: 99%

Evaluation of Antibiotics Residues in Milk and Meat Using Different Analytical Methods

Getahun

Abebe

Sendekie

et al. 2023

International Journal of Analytical Chemistry

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Veterinary drugs are pharmacologically and biologically active chemical agents. At present, veterinary drugs are extensively used to prevent and treat animal diseases, to promote animal growth, and to improve the conversion rate of feed. However, the use of veterinary drugs in food-producing animals may leave residues of the parent compounds and/or their metabolites in food products resulting in harmful effects on humans. To ensure food safety, sensitive and effective analytical methods have been developing rapidly. This review describes sample extraction and cleanup methods, and different analytical techniques are used for the determination of veterinary drug residues in milk and meat. Sample extraction methods, such as solvent extraction, liquid-liquid extraction, and cleanup methods such as dispersive solid-phase extraction and immunoaffinity chromatography, were summarized. Different types of analytical methods such as microbial, immunological, biosensor, thin layer chromatography, high-performance liquid chromatography, and liquid chromatography–tandem mass spectrometry were discussed for the analysis of veterinary drug residues in animal-derived foods. Liquid chromatography–tandem mass spectrometry is the most widely used analytical technique for the determination of antibiotic drug residues. This is due to the powerful separation of LC and accurate identification of MS, and LC-MS/MS is more popular in the analysis of veterinary drug residues.

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Section: Extra-label Drugmentioning

confidence: 99%

Evaluation of Antibiotics Residues in Milk and Meat Using Different Analytical Methods

Getahun

Abebe

Sendekie

et al. 2023

International Journal of Analytical Chemistry

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“…In addition, different approaches, many based on statistics, have been used to determine the withdrawal time for veterinary drugs in foodproducing animals. These include the use of half-life multipliers (number of half-lives contained within the withdrawal time), the withdrawal-period estimator algorithm [30,31], the non-parametric methods for specific drugs [32], and the physiologically based pharmacokinetic modeling [33][34][35][36]. The statistical linear regression method is the most widely used and recommended by both FDA (at 99% of tolerance interval with 95% confidence intervals) and EU (at 95% tolerance with 95% confidence intervals), although it was not considered the best approach [37].…”

Section: Lack Of Global Harmonization: Mrls/tolerances and Withdrawal Periodsmentioning

confidence: 99%

“…These singularities, related to the different MRLs, procedures for calculating WP, and drug tissue residue data considered, have been demonstrated. When Udiani et al [38] estimated the WP for veterinary drugs, such as sulfamethazine in swine liver [35] and flunixin in calf liver [26], different values were obtained depending on the data and the MRL taken into account. In the same way, tissue residue levels of florfenicol and tylosin in different tissues were considered to determine the WP by the linear regression method with both recommendations (FDA and EU), and different values were obtained [39].…”

Section: Lack Of Global Harmonization: Mrls/tolerances and Withdrawal Periodsmentioning

confidence: 99%

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

Cantón

Lanusse

Moreno

2021

Animals

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Drugs are used in veterinary medicine to prevent or treat animal diseases. When rationally administered to livestock following Good Veterinary Practices (GVP), they greatly contribute to improving the production of food of animal origin. Since humans can be exposed chronically to veterinary drugs through the diet, residues in food are evaluated for effects following chronic exposures. Parameters such as an acceptable daily intake (ADI), the no-observed-adverse-effect level (NOAEL), maximum residue limits (MRLs), and the withdrawal periods (WPs) are determined for each drug used in livestock. Drug residues in food exceeding the MRLs usually appear when failing the GVP application. Different factors related either to the treated animal or to the type of drug administration, and even the type of cooking can affect the level of residues in edible tissues. Residues above the MRLs can have a diverse negative impact, mainly on the consumer’s health, and favor antimicrobial resistance (AMR). Drug residue monitoring programmes are crucial to ensure that prohibited or authorized substances do not exceed MRLs. This comprehensive review article addresses different aspects of drug residues in edible tissues produced as food for human consumption and provides relevant information contributing to rational pharmacotherapy in food-producing animals.

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Automation and applications of the tolerance limit method in estimating meat withdrawal periods for veterinary drugs

Udiani

Mason

Smith

et al. 2018

Computers and Electronics in Agriculture

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Tissue concentrations of sulfamethazine and tetracycline hydrochloride of swine ( Sus scrofa domestica ) as it relates to withdrawal methods for international export

Cited by 7 publications

References 14 publications

Evaluation of Antibiotics Residues in Milk and Meat Using Different Analytical Methods

Evaluation of Antibiotics Residues in Milk and Meat Using Different Analytical Methods

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

Automation and applications of the tolerance limit method in estimating meat withdrawal periods for veterinary drugs

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