Tissue concentrations of manganese and adrenal function

Hughes, E. H.; Meyer, St.; Gc, Cotzias

doi:10.1152/ajplegacy.1966.211.1.207

Cited by 25 publications

(13 citation statements)

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“…The present paper suggests the existence of biological controls for manganese in man, similar to those in other mammals (16)(17)(18)(19)(20). Thereafter it documents a slow turnover of this metal in one patient with hydralazine disease and in seven with active rheumatoid arthritis.…”

supporting

confidence: 72%

“…A slow turnover of the metal is evident only in the total body, liver, and thyroid measurements, but not in those obtained over the thigh (compare with Table III). The hormone had accelerated only these slow rates, whereas the rate of loss of the isotope from the thigh may even have become decelerated (18,19). The latter finding was not clearly evident in all records.…”

Section: Methodsmentioning

confidence: 82%

“…The long-lived (tj = 314 days) gamma rayemitting, carrier-free MMn++, as well as the nonradioactive, natural 6'Mn++ (MnSO), have been discussed earlier (16)(17)(18)(19)(20). Each batch of radioisotope was first tested for toxicity in rabbits or mice.…”

Section: Methodsmentioning

confidence: 99%

“…most rapid turnover (16)(17)(18)(19)(20) with the thyroid RESULTS ranking as second. By contrast, the ear and the Turnover of "4manganese.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, both glucocorticoid hormones (18) and adrenocorticotropin ACTH (19) shifted manganese from the liver to the carcass in mice. It seemed worthwhile to seek similar effects in man.…”

Section: Introductionmentioning

confidence: 99%

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Slow turnover of manganese in active rheumatoid arthritis accelerated by prednisone

Cotzias¹,

Papavasiliou²,

Hughes³

et al. 1968

J. Clin. Invest.

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Total body and area counts of intravenously injected 54Mn were measured periodically in 29 in-patients. A heterogeneous group of 19 control patients showed fair reproducibility in the immediate distribution, and considerable individual variance in the subsequent loss of the isotope. Eight studies of the effects of feeding excesses of manganous sulfate to five patients showed acceleration of the rate of loss of the radioisotope from the whole body and the liver. These findings seem compatible with the presence of control mechanisms in man, operating to vary the metal's excretion, while tending to preserve constancy of its concentration in tissues.Slow turnover rates of the metal were demonstrated in seven out of eight patients with active rheumatoid arthritis, in one with hydralazine disease, but not in one arthritic undergoing an impressive, spontaneous remission. Statistically significant differences were encountered in the measurements of 54Mn turnover of the total body, the thyroid, and the liver.Administration of prednisone induced clinical improvement and significant acceleration of these turnovers. Slow turnovers are characteristic of nutritional manganese deficiency. Therefore, serum and blood manganese determinations were performed by neutron activation analysis on 14 control patients, and on six patients with active rheumatoid arthritis. A statistically significant elevation of the red cell manganese concentration was encountered in patients with rheumatoid arthritis. This argued against the presence of classical trace-

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supporting

confidence: 72%

Section: Methodsmentioning

confidence: 82%