Tissue Concentrations of Cefepime in Acute Cholecystitis Patients

Pharmacokinetics of cefepime in bile and gall bladder tissue after prophylactic administration in patients with extrahepatic biliary diseases

“…Furthermore, there was also a good correlation between delta time and serum and gall bladder tissue concentrations, whilst there was no correlation between serum and bile fluid concentrations in accordance with previous studies [7,8].…”

“…In a previous study [7], cefepime tissue concentrations in patients undergoing elective cholecystectomy ca. 8 h after a 2 g i.v.…”

“…The pharmacokinetics of cefepime in the biliary tract after i.v. administration of multiple doses has been studied previously [7][8][9].…”

Cefepime versus ceftazidime: considerations for empirical use in critically ill patients

“…Penetration into the CNS was 23-37% of serum concentrations (dose, 2 g q8h); penetration similar to other cephalosporins. Peritoneal fluid Study group: elective cholecystectomy patients [96]. Tissue 7.63 ± 14.17 g/mL vs. serum 5.66 ± 6.80 g/mL at 8.58 ± 3.53 h; penetration sufficient for susceptible organisms.…”

Biliary Excretion of Antimicrobial Drugs

“…Pharmacokinetics values for cefepime were determined in patients with acute cholecystitis who had undergone cholecystectomy. In one study Okamoto et al [67] administered the cefepine to 15 patients with acute cholecystitis and found that cefepime concentration in bile ranged from 0.2 to 70 Ìg/ ml 8 h after administration of the dose. However, the volume of bile and the total amount of cefepime excreted in the bile in these patients are not known [68].…”