Tissue composition of major and trace elements in uremia and hypertension

Indraprasit, Suchati; Alexander, G. V.; Gonick, Harvey C.

doi:10.1016/0021-9681(74)90082-4

Cited by 48 publications

(14 citation statements)

References 45 publications

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“…Most authors have taken samples for analysis from subjects who have died abruptly in accidents, but they hav,e also included subjects with 'known diseases (1,9,25). Even subjects with dissimilar diseases have been used as control groups in studies concerning tissue copper concentrations in certain other diseases (11,14,15). In our study we collected samples from autopsy subjects who were obviously healthy prior to death and who at autopsy were verified to have been kiJled accidentally.…”

Section: Resultsmentioning

confidence: 99%

“…No differences in liver oopper levels have been found between subjects who died from hypertensive disease or neoplastic disease and subjects dying from other causes (14). However, these findings are not unif.orm; a decreased liver ,oopper concentration has been reported to occur in hypertensive patients (11). Low hepaticcopperoontent has been reported in patients with a hepatic neoplasm or with diabetes mellitus (20).…”

Section: Resultsmentioning

confidence: 99%

“…Although the literature on the copper content of human tissues is extensive, only a few studies have evaluated the effect of age (9,11,22) and sex (14). In our study the order of tissues with respect to desoending copper concentrations was liver, heart, kidney, pancreas, lung, musde and aorta.…”

Section: Resultsmentioning

confidence: 99%

“…Besides, some materilals comprise not only healthy persons who had died :in .aocidents, but also chronically ill, hospitalized patients (1,7,9,11,14,16,25).…”

Section: Resultsmentioning

confidence: 99%

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Biologically active metals in human tissues. I. The effect of age and sex on the concentration of copper in aorta, heart, kidney, liver, lung, pancreas and skeletal muscle.

Vuori¹,

Huunan-Seppälä²,

Kilpiö³

1978

Scand J Work Environ Health

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Biologically active metals in human tissues. I. The effect of age and sex on the concentration of copper in aorta, heart, kidney, liver, lung, pancreas and skeletal muscle.by Vuori E, Huunan-Seppälä A, Kilpiö JO 4 (1978) 167-175. Autopsy specimens of aorta, heart, kidney, liver, lung, pancreas and skeletal muscle were collected from 86 accident victims. The ,capper concentration~n each tissue was determined w1th aJtomic absorption spectrophotometry. The descending order of the tissues in respect to capper COThcenltrartJiJon was: liver, heart, kidn'ey, pan-cr,eas, lung, muscle, and aorta. No signdfioaoIlJt difference was found in 1Jhe oopper leV€lls of samples from male and female autopsies. When the effect of age on the averag,e copper concentration was studied, liver and kidney showed oa decreaffiJng concentrntiQn .up to matumy, the copper oonoenltratdon in pancreas and s'keIetal muscle showed a

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Besides, some materilals comprise not only healthy persons who had died :in .aocidents, but also chronically ill, hospitalized patients (1,7,9,11,14,16,25).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Biologically active metals in human tissues. I. The effect of age and sex on the concentration of copper in aorta, heart, kidney, liver, lung, pancreas and skeletal muscle.

Vuori¹,

Huunan-Seppälä²,

Kilpiö³

1978

Scand J Work Environ Health

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“…The kidney is the main excretory organ for Si, almost entirely by glomerular filtration [32], Renal insufficiency is invariably associated with increased plasma Si levels (table 2) [1,2,[18][19][20][21], which tend to rise in parallel with the increase in serum creatinine levels. Tubular secretion of Si in uremic patients has been reported [19], although not confirmed by others [20].…”

Section: Silicon Excess In Dialysismentioning

confidence: 99%

Silicon-Related Syndrome in Dialysis Patients

Saldanha

Gonick²,

Rodriguez³

et al. 1997

Nephron

Self Cite

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Two dialysis patients with markedly elevated plasma silicon (Si) levels (3,849 and 2,350 μg/l, respectively) and a presumed Si-related syndrome are described in this report. One patient presented with transient hypercalcemia in the face of low PTH, vitamin D and plasma Al levels. Both patients had painful, nodular skin eruptions and aberrant hair growth, characterized as perforating folliculitis on skin biopsy, compatible with known effects of organosilicon compounds in man and animals. Plasma Si was found to be moderately elevated in 30 dialysis patients studied at random (710 ± 53 μg/l, dialysis, vs. 152 ± 9 μg/l, normal control), but there was no significant difference between the arterial values before and after dialysis, implying that the source of Si was ingested foods and fluids rather than dialysate. In these patients, plasma Si was weakly correlated with serum calcium as well as with serum calcium corrected for serum albumen, indicating that Si, like aluminum, may affect calcium metabolism.

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Silver and Gold

Juberg¹,

Hearne²

2001

Patty's Toxicology

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Silver, an element of the II(B) Group, is in the second transition series of the periodic table. It is a white, lustrous, relatively soft and very malleable metal. Silver has high thermal and electrical conductivity and resists oxidation in air that is devoid of hydrogen sulfide. Silver is insoluble in water although it can exist in an aqueous environment in three cationic forms, Ag(I), Ag(II), and Ag(III), in addition to its metallic state (AgO). Most silver compounds are made from silver nitrate, which is prepared from silver metal. The toxicological properties of many substances depend on the particular chemical species of that substance, and silver is no exception. Although silver exists in its elemental state and many references within the scientific literature are simply to “silver,” it is important to stress that speciation is critical to understanding the potential for toxicity and subsequent health effects. As with many substances, a discussion of each silver species' toxicological properties would appear rather incomplete due to the lack of information available. Given these factors, it is more logical to discuss silver based on specific target organs or endpoints of concern (i.e., irritation, carcinogenicity) and to provide information on relevant silver species within this context. An explanation for the apparent lack of toxicity information on numerous species of silver is that many of the commonly used forms are insoluble in aqueous media and therefore are not readily tested in laboratory animal species. This property of many silver species may, in part, also explain its apparent lack of acute or chronic toxicity in humans based on years of occupational and workplace experience. Gold is a dense, yet malleable, lustrous, yellow metal widely found in nature as elemental gold or in combination with sulfides in igneous rocks and ores. Gold is very stable and nonreactive and does not burn or oxidize in air. Other than in its atomic state, the metal does not react with oxygen, sulfur, or selenium at any temperature. Gold does react with various oxidizing agents at ambient temperatures provided a good ligand is present to lower the redox potential below that of water. Therefore, gold is not attacked by most acids under ordinary conditions and is stable in basic media. Early uses of gold were in medicinal, antibacterial, and dental applications dating back to the ancient Chinese and Egyptians. Gold salts have been used therapeutically, without notable success in treating several diseases, including asthma, leprosy, syphilis, and tuberculosis. Presently, gold salts have therapeutic usefulness (chrysotherapy) limited to treating rheumatoid arthritis of the peripheral joints and in certain rare skin diseases. Gold salts are most efficacious in the early stages of arthritic disease and reduce the inflammatory process but without inducting any repair process in the joints. Two generally recognized disadvantages to chrysotherapy include relapse following discontinuation of treatment and potential toxicity associated with gold salts. Because of its distribution in the body and short half‐life, colloidal radioactive gold, has been used as a radiation source in treating cancer. As noted for silver, a discussion of the toxicological properties for each gold compound is not practical from the standpoint of available information. Therefore, this discussion on gold and its toxicity potential centers on particular aspects of gold toxicology, and within this framework, where a particular gold compound has been evaluated, it are discussed.

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Tissue composition of major and trace elements in uremia and hypertension

Cited by 48 publications

References 45 publications

Biologically active metals in human tissues. I. The effect of age and sex on the concentration of copper in aorta, heart, kidney, liver, lung, pancreas and skeletal muscle.

Biologically active metals in human tissues. I. The effect of age and sex on the concentration of copper in aorta, heart, kidney, liver, lung, pancreas and skeletal muscle.

Silicon-Related Syndrome in Dialysis Patients

Silver and Gold

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