Tissue bioavailability of anthocyanins from whole tart cherry in healthy rats

Kirakosyan, Ara; Seymour, Eric; Wolforth, Janet; McNish, Robert W.; Kaufman, Peter B.; Bolling, Steven F.

doi:10.1016/j.foodchem.2014.08.114

Cited by 50 publications

(59 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, it should be taken into consideration that the improvement of the oxidative/antioxidative status of the serum (reflecting the whole body oxidative/antioxidative status) and bone tissue by AME administration under physiological conditions and exposure to Cd might be related to the ability of polyphenols to penetrate into tissues (including bone). These compounds have been reported to be present in various organs of rats, including target organs for Cd, such as kidneys and liver [37]; however, their penetration into the bone tissue has not been investigated, but it cannot be excluded. The available data indicating that consumption of polyphenols improves bone turnover and BMD in both human [21] and experimental animals [16,23] confirm the possibility of the direct impact of these compounds on bone status.…”

Section: Figmentioning

confidence: 99%

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

et al. 2016

View full text Add to dashboard Cite

!Recently, we demonstrated in a rat model that consumption of a polyphenol-rich extract obtained from the berries of Aronia melanocarpa could protect from cadmium-induced disorders in bone turnover and changes in bone mineral status. The aim of this study was to investigate whether the osteoprotective effect of this extract is mediated by the oxidative defense system. Enzymatic and nonenzymatic antioxidants, total antioxidative and oxidative status, hydrogen peroxide, and markers of oxidative protein, lipid, and DNA damage were determined in bone tissue at the distal femoral epiphysis of female Wistar rats receiving 0.1 % aqueous A. melanocarpa extract (prepared from the lyophilized commercial extract containing 65.74 % of polyphenols) as the only drinking fluid and/or cadmium in the diet (1 and 5 mg/kg) for 3, 10, 17, and 24 months. The total oxidative and antioxidative status of the serum was also evaluated. The administration of A. melanocarpa extract provided significant protection from cadmium-induced oxidative stress in the bone and serum, and from lipid peroxidation and oxidative damage to the protein and DNA in the bone tissue. Numerous correlations were noted between indices of the oxidative/antioxidative bone status and markers of bone metabolism previously assayed in the animals receiving A. melanocarpa extract. The results allow the conclusion that the ability of A. melanocarpa extract to mediate the oxidative defense system and prevent oxidative modifications of protein, lipid, and DNA in the bone tissue plays an important role in its osteoprotective action under exposure to cadmium. The findings provide further evidence supporting our suggestion that chokeberry may be a promising natural agent for protection against the toxic action of cadmium in women chronically exposed to this metal. Abbreviations

show abstract

Section: Figmentioning

confidence: 99%

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Pharmacokinetic trial to evaluate the bioavailability of anthocyanins and colonic polyphenol metabolites after consumption of aronia berry extract in plasma and urine [96] Pharmacokinetic characterization and bioavailability of strawberry anthocyanins relative to meal intake [97] Bioavailability studies and anticancer properties of malvidin-based anthocyanins, pyranoanthocyanins and nonoxonium derivatives [98] Effect of red cabbage fermentation on anthocyanin bioavailability and plasma antioxidant capacity in humans [99] Bioavailability of red raspberry anthocyanins and ellagitannins: new insights [82] Bioavailability and uptake of anthocyanins and their metabolites from grape/blueberry juice and smoothie in vivo and in vitro [100] Tissue bioavailability and intake of tart cherry anthocyanins [101] Confirmation and identification of tart cherry anthocyanins in several target tissues of healthy rats [102] Bioactive anthocyanins in 'Queen Garnet' plum: maturity and bioavailability [103] Use of anthocyanins as bioactive colourants in lipstick formulations [104] Application of the developed flavonoid-poor menu meals to the study of the bioavailability of bilberry anthocyanins as model flavonoids [105] Anthocyanin stability, mucus binding, and uptake into epithelial cells in healthy individuals that retained red grape or chokeberry juice in the mouth [106] Absorption and bioavailability of anthocyanins across the gastrointestinal mucosa [107] Effects of processing sour cherry fresh fruit to the final juice product on the content of anthocyanins and other related polyphenols [108] …”

Section: Comments Referencesmentioning

confidence: 99%

Antioxidant Capacity of Anthocyanin Pigments

Martín¹,

Kuskoski²,

Navas³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

View full text Add to dashboard Cite

Anthocyanins are a family of natural pigments classified into the group of flavonoids, considered to be responsible for the color and taste of many fruits and vegetables, i.e. berries. Anthocyanins are common components of the human diet. Besides their interest as colorant because of their coloring properties, the study of anthocyanin compounds stems from their wide applicability in the prevention and even in the treatment of various human diseases. However, various aspects of the pharmacological roles of anthocyanins remain in the dark, having still several obstacles to the development of robust diets or prescribing lines on consumption of anthocyanins. The chemical structure of anthocyanins determines in large measure its capacity and efficacy as an antioxidant agent. In this study, the following aspects are reviewed: the antioxidant effect of anthocyanin pigments; the oxidative stress, the bioavailability after intake and biological aspects of anthocyanins, the method for measuring the antioxidant activity of anthocyanins, the relationship between structure and activity; and the influence of the anthocyanins in the antioxidant activity of wines. Finally an overview of some potential uses in food industry is attempted mainly focusing in the anthocyanin encapsulation topic. Attention has been paid to the more recent publications in the field.

show abstract

“…Studies using cell lines, animal models, and humans demonstrated that the phytochemicals found in tart cherry confer health benefits by inducing cell-cycle arrest and apoptosis in precancerous and cancer cells (Kang et al 2003;Bobe et al 2006;Martin and Wooden 2012;Sehitoglu et al 2014), decreasing triglyceride and total cholesterol levels (Seymour et al 2008), reducing inflammation (Seeram et al 2001b;Tall et al 2004;Seymour et al 2009;Ou et al 2012), and decreasing oxidative stress (Kim et al 2005;Traustadottir et al 2009). Furthermore, a study by Kirakosyan showed that cherry anthocyanins accumulated in the brain of young rats after 3 weeks of feeding with either 1 or 10 % tart cherry-supplemented diets in a dose-dependent manner (Kirakosyan et al 2015). Therefore, cherry anthocyanins may improve behavior by acting directly to improve brain cell function, signaling, and/or extraneuronal parameters of survival, such as inflammation, within the aging brain.…”

Section: Introductionmentioning

confidence: 99%

Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats

Thangthaeng

Poulose

Gomes

et al. 2016

AGE

View full text Add to dashboard Cite

High consumption of fruits and vegetables has been associated with reduced risk of debilitating diseases and improved cognition in aged populations. These beneficial effects have been attributed to the phytochemicals found in fruits and vegetables, which have previously been shown to be anti-inflammatory and modulate autophagy. Tart cherries contain a variety of potentially beneficial phytochemicals; however, little research has been done to investigate the effects of tart cherry on the aging brain. Therefore, the purpose of this study was to determine if tart cherry supplementation can improve cognitive and motor function of aged rats via modulation of inflammation and autophagy in the brain. Thirty 19-month-old male Fischer 344 rats were weight-matched and assigned to receive either a control diet or a diet supplemented with 2 % Montmorency tart cherry. After 6 weeks on the diet, rats were given a battery of behavioral tests to assess for strength, stamina, balance, and coordination, as well as learning and working memory. Although no significant effects were observed on tests of motor performance, tart cherry improved working memory of aged rats. Following behavioral testing, the hippocampus was collected for western/densitometric analysis of inflammatory (GFAP, NOX-2, and COX-2) and autophagy (phosphorylated mTOR, Beclin 1, and p62/SQSTM) markers. Tart cherry supplementation significantly reduced inflammatory markers and improved autophagy function. Daily consumption of tart cherry reduced age-associated inflammation and promoted protein/cellular homeostasis in the hippocampus, along with improvements in working memory. Therefore, addition of tart cherry to the diet may promote healthy aging and/or delay the onset of neurodegenerative diseases.

show abstract

Tissue bioavailability of anthocyanins from whole tart cherry in healthy rats

Cited by 50 publications

References 37 publications

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

Antioxidant Capacity of Anthocyanin Pigments

Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats

Contact Info

Product

Resources

About