Tissue-based long non-coding RNAs “PVT1, TUG1 and MEG3” signature predicts Cisplatin resistance in ovarian Cancer

El-Khazragy⃰, Nashwa; Mohammed, Hayam F; Yassin, Mohamed; Elghoneimy, K.K.; Bayoumy, Walid Abd Elmenim; Hewety, Amr; Magdoub, Hekmat M. El; Elayat, Wael M.; Zaki, W S; Safwat, Gehan; Mosa, Mai; Zedan, Khouloud; Salem, Salema; Bannunah, Azzah M.; Mansy, Azza El‐Sayed

doi:10.1016/j.ygeno.2020.08.005

Cited by 20 publications

(17 citation statements)

References 32 publications

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“…In the present study, we successfully constructed the cisplatin-resistant-related ceRNA network including 71 DElncRNAs, 121 DEmRNAs and 8 DEmiRNAs. The selected ncRNAs in this network conformed to the ceRNA rules and some of them were demonstrated to be well-established drug-resistant-related genes or signaling pathways in many cancers [25][26][27][28][29][30][31][32]. Therefore, this network provided a credible and systematic perspective on the potential function of lncRNAs in cisplatin resistance of GC.…”

Section: Discussionmentioning

confidence: 97%

“…6a-b). We noted that 5 DElncRNAs, including LINC00200 [25], LINC00460 [26], MEG3 [27], NEAT1 [28] and UCA1 [29], have been substantiated to be chemoresistant-related genes. Interestingly, some studies have also reported that MEG3, NEAT1 and UCA1 exerted vital roles in regulating cisplatin resistance in ovarian cancer [30], lung cancer [31] and gastric cancer [32].…”

Section: Construction Of Cisplatin-resistant-related Cerna Networkmentioning

confidence: 99%

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Construction of a competing endogenous RNA network and identification of potential regulatory axes in gastric cancer chemoresistance

Yang

Fang

et al. 2022

Pathology - Research and Practice

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Section: Discussionmentioning

confidence: 97%

Section: Construction Of Cisplatin-resistant-related Cerna Networkmentioning

confidence: 99%

Construction of a competing endogenous RNA network and identification of potential regulatory axes in gastric cancer chemoresistance

Yang

Fang

et al. 2022

Pathology - Research and Practice

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“…LncRNAs regulate epigenetic, transcriptional, and translational responses, and are critical regulators of immune cell differentiation, especially for type-2 immune responses (20,21). Previous studies have suggested that lncRNA TUG1 participates in the development of cancers (22,23), hypoxic pulmonary hypertension (24), and Alzheimer's disease (25). Moreover, the experimental asthma model suggested that lncRNA TUG1 promotes airway smooth muscle cell proliferation and migration by sponging miR-590-5p/FGF1 (26).…”

Section: Discussionmentioning

confidence: 99%

LncRNATUG1 Facilitates Th2 Cell Differentiation by Targeting the miR-29c/B7-H3 Axis on Macrophages

et al. 2021

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The role of long non-coding RNAs (lncRNA) in asthma remains unclear. In this study, we examined the role of long non-coding RNA taurine upregulated 1 (lncRNA TUG1) in asthma. We found that lncRNA TUG1 is one of the differentially expressed lncRNAs in the monocytes of asthmatic children and is associated with Th cell differentiation. LncRNA TUG1 and miR-29c are mainly distributed in the cytoplasm of macrophages. Our data suggested that lncRNA TUG1 increased in macrophages stimulated by House Dust Mite in a dose-dependent manner. Using loss- and gain of function strategy, we found that miR-29c might regulate Th2 cell differentiation by directly targeting co-stimulatory molecule B7-H3. Furthermore, down-regulation of lncRNA TUG1 decreased the level of GATA3 in CD4+T cells and was associated with miR-29c/B7-H3 axis. Moreover, the dual-luciferase reporter assay confirmed that lncRNA TUG1 serves as a competing endogenous RNA to sponge miR-29c. According to the rescue experiment, lncRNA TUG1 regulated Th2 cell differentiation via miR-29c. These data suggest that lncRNA TUG1 in macrophages regulates Th2 cell differentiation via miR-29c/B7-H3 axis.

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“…MEG3 is one of the three signature lncRNA that can be used to predict cisplatin resistance in OC. Upregulated PVT1 and downregulated TUG1 and MEG3 have high sensitivity and specificity in predicting chemoresistance and are negatively associated with OS and progression-free survival [202]. Sensitivity to cisplatin can be restored with curcumin treatment, as it leads to demethylation of the MEG3 promoter, sponging of miR-214 by MEG3, and consequent reduction of drug resistance [203].…”

Section: Meg3mentioning

confidence: 99%

(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers

Sabol

Calleja‐Agius

Fiore

et al. 2021

Cancers

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Rare ovarian cancers (ROCs) are OCs with an annual incidence of fewer than 6 cases per 100,000 women. They affect women of all ages, but due to their low incidence and the potential clinical inexperience in management, there can be a delay in diagnosis, leading to a poor prognosis. The underlying causes for these tumors are varied, but generally, the tumors arise due to alterations in gene/protein expression in cellular processes that regulate normal proliferation and its checkpoints. Dysregulation of the cellular processes that lead to cancer includes gene mutations, epimutations, non-coding RNA (ncRNA) regulation, posttranscriptional and posttranslational modifications. Long non-coding RNA (lncRNA) are defined as transcribed RNA molecules, more than 200 nucleotides in length which are not translated into proteins. They regulate gene expression through several mechanisms and therefore add another level of complexity to the regulatory mechanisms affecting tumor development. Since few studies have been performed on ROCs, in this review we summarize the mechanisms of action of lncRNA in OC, with an emphasis on ROCs.

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Tissue-based long non-coding RNAs “PVT1, TUG1 and MEG3” signature predicts Cisplatin resistance in ovarian Cancer

Cited by 20 publications

References 32 publications

Construction of a competing endogenous RNA network and identification of potential regulatory axes in gastric cancer chemoresistance

Construction of a competing endogenous RNA network and identification of potential regulatory axes in gastric cancer chemoresistance

LncRNATUG1 Facilitates Th2 Cell Differentiation by Targeting the miR-29c/B7-H3 Axis on Macrophages

(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers

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