Tissue adhesives in gastrointestinal anastomosis: a systematic review

Vakalopoulos, Konstantinos A.; Daams, Freek; Wu, Zhi‐Yong; Timmermans, Lucas; Jeekel, J.; Kleinrensink, Gert-Jan; Ham, Arie van der; Lange, Johan F.

doi:10.1016/j.jss.2012.12.043

Cited by 110 publications

(88 citation statements)

References 64 publications

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“…These results are in line with those from other studies on sealing of gastrointestinal anastomoses with FG [47,48] that were not included in the present review due to a lack or inadequate evaluation of healing. The results from these studies are inconsistent, but a number of human and experimental studies have revealed positive effects on anastomotic leakage, bursting pressure or anastomotic strength.…”

Section: Discussionsupporting

confidence: 91%

“…Unfortunately, many of these attempts have failed to show convincing results [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48]. Numerous studies have reported on the sealing of gastrointestinal anastomoses with fibrin glue (FG), also called fibrin sealant.…”

Section: Introductionmentioning

confidence: 99%

“…In most studies on FG, the commercially produced FG was used, but in some studies FG was produced locally in the clinical setting from human or animal blood. Positive effects of FG on intestinal anastomoses have been found in both human and experimental studies [47,48]. However, healing has not been the primary end point in these studies.…”

Section: Introductionmentioning

confidence: 99%

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Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

et al. 2014

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Background/Aim: Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic sealing with FG might be due to the mechanical/physical properties, the increased healing of the anastomoses or both. The aim of this systematic review was to evaluate the existing evidence on the healing effects of FG on gastrointestinal anastomoses. Methods: PubMed, EMBASE and the Cochrane databases were searched for studies evaluating the healing process of gastrointestinal anastomoses after any kind of FG application. The search period was from 1953 to December 2013. Results: Twenty-eight studies were included in the qualitative synthesis. These studies were all experimental studies, since no human studies used histological or biochemical evaluation of healing. In 7 of the 28 studies, a positive effect of FG on healing was found, while 8 studies reported a negative effect and 11 studies found no effect. Furthermore, 2 studies reported unclear results. The difference in the study outcome was independent of the study design and the type of FG used. Conclusion: In the available studies, FG did not consistently have a positive influence on the healing of gastrointestinal anastomoses. It is consequently plausible that the positive effect of FG sealing of gastrointestinal anastomoses, if there is any, may be due to a mechanical sealing effect rather than due to improved healing per se.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

et al. 2014

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“…In many cases, they have concluded that fibrin-based biological adhesive reduces the occurrence of postoperative fistula. However, most of these studies were not controlled, so they lacked sufficient power to affirm this hypothesis and recommend the systematic use of adhesives in gastrointestinal anastomoses as a method of preventing leakage [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs

Oliver¹,

Garijo²,

Estéves³

et al. 2015

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Abstract:Objective: To analyse hospital costs in the pre-, and intra-and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo ® ). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.

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“…При изучении вопроса о влиянии клеев, защит-ных пленок и других средств на предотвращение НШКРА значимых различий не выявлено [30,39,43]. Однако у пациентов, которым применялась пленка ЭСБАДХ, частота недостаточности была в 2 раза ниже -7,6 против 16,5 % [13].…”

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Colorecral Anastomosis Failure (Literature Review)

Шайхутдинович¹,

Иванович²

2016

Sib. onkol. ž.

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Tissue adhesives in gastrointestinal anastomosis: a systematic review

Cited by 110 publications

References 64 publications

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs

Colorecral Anastomosis Failure (Literature Review)

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