Tissue Adhesives for Repairing Inguinal Hernia: A Preliminary Study

Kato, Yoshifumi; Yamataka, Atsuyuki; Miyano, Go; Tei, Eri; Koga, Hiroyuki; Lane, Geoffrey J.; Miyano, Takeshi

doi:10.1089/lap.2005.15.424

Cited by 28 publications

(26 citation statements)

References 15 publications

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“…In order to satisfy these requirements, animal models have been used to determine whether surgical glue injection can be used to maintain closure of the PPV [2,3,15].…”

Section: Discussionmentioning

confidence: 99%

A human case study demonstrating the safety and effectiveness of laparoscopic surgical glue injection hernioplasty for pediatric indirect inguinal hernia

Park

Hong

Chang

et al. 2014

Journal of Pediatric Surgery Case Reports

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a b s t r a c tThe purpose of this pediatric case report was to provide clinical evidence supporting the safety and effectiveness of laparoscopic surgical glue injection hernioplasty (LSGIH) in humans for indirect inguinal hernia repair. We performed LSGIH on a female newborn for a right indirect inguinal hernia that was incidentally discovered during a laparoscopic right salphingo-oophorectomy for prenatal right ovarian cyst torsion. Under laparoscopic control, the internal ring was closed by injection of Histoacryl Ò into the internal opening of the patent processus vaginalis. One month later, the patient underwent another laparoscopic operation due to torsion of a newly developed contralateral ovarian cyst. During the second operation, we were able to clearly observe the previous LSGIH site. Despite partial absorption of the injected Histoacryl Ò , the opening of the internal ring remained closed without any evidence of adhesions. This case supports LSGIH as a simple, safe, and useful technique for pediatric inguinal hernioplasty. However, more clinical trials should be performed to confirm the long-term reliability and safety of LSGIH in humans.

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“…In order to satisfy these requirements, animal models have been used to determine whether surgical glue injection can be used to maintain closure of the PPV [2,3,15].…”

Section: Discussionmentioning

confidence: 99%

A human case study demonstrating the safety and effectiveness of laparoscopic surgical glue injection hernioplasty for pediatric indirect inguinal hernia

Park

Hong

Chang

et al. 2014

Journal of Pediatric Surgery Case Reports

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“…La primera comunicación relacionada con la utilización de N-butilcianocrilato en hernioplastia inguinal con malla fue realizada en Inglaterra por Farouk 4 , siguiéndolo posteriormente otros estudios que demuestran la factibilidad de esta técnica 5,6 con resultados promisorios, incluso por vía laparoscópica 7,8 . Hubo un puntaje bajo de dolor postoperatorio, y aún ausencia de molestias locales al seguimiento de corto plazo en estos casos, lo que también se ha comunicado en los otros trabajos mencionados.…”

Section: Discussionunclassified

Hernioplastia inguinal con malla sin tensión: Experiencia con adhesivo N-butil-cianoacrilato

2008

Rev Chil Cir

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RESUMENLa hernioplastia de Lichtenstein es en la actualidad una de las técnicas más utilizadas en la reparación de hernia inguinal por su baja morbilidad y recurrencia y la reproducibilidad de sus resultados. Sin embargo, no está exenta de problemas postoperatorios como dolor e irritación local crónica atribuidos a las suturas para la fijación de la malla. El propósito del presente trabajo es mostrar los resultados a corto plazo utilizando en esta técnica un adhesivo biodegradable como medio de fijación, en reemplazo de suturas. Material y Método: Estudio prospectivo de 13 pacientes con hernia inguinal, 5 de ellas bilaterales, operados con la técnica de Lichtenstein, con un total de 18 hernioplastias. Para la fijación de la malla de polipropileno se empleó N-butil-cianocrilato. La edad media del grupo fue 45,8 años, con extremos de 25 y 62. El 84,6% fueron de sexo masculino. El 50% y 39% eran, respectivamente, hernias tipo II y IIIa de Nyhus. Se excluyeron las hernias crurales y recidivadas. Se incluye una escala lineal análoga de 0 a 10 para evaluación del dolor postoperatorio. Seguimiento a corto plazo, media 8 meses, con extremos de 1 a 18 meses. Resultados: Estadía hospitalaria media 1,46 días. Escala lineal del dolor media 1er día 1,8 + 1,1 y 7° día 0. Evolución satisfactoria en todos los casos. Un paciente presenta hematoma leve en postoperatorio inmediato, de resolución espontánea. No hubo complicaciones mayores ni atribuibles al adhesivo. Sin recurrencias hasta cierre del estudio. Conclusiones: El N-butil-cianocrilato, para fijación de la malla en la técnica de Lichtenstein, presentó buenos resultados inmediatos, reforzando los beneficios y características de libre de tensión de la técnica, evitando la morbilidad del uso de suturas. Por otra parte, los costos de suturas y cantidad de adhesivo son comparables en su utilización PALABRAS CLAVE: Hernia inguinal, Lichtenstein, uso de adhesivos tisulares. SUMMARYBackground: Lichtenstein hernioplasty is one of de most popular methods for inguinal hernia repair, due to its low rate of complications and recurrence. However it has some postoperative problems such as pain and local chronic irritations attributed to sutures for mesh fixation. Aim: To report the short term results of the use of a biodegradable adhesive to fix the mesh in Lichtenstein technique, instead of sutures. Material and Methods: Prospective study of 13 patients aged 25 to 62 years (11 men) with inguinal hernia, 5 bilateral,

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“…In addition, there is a clinical report of the successful use of photopolymerized PEG adhesives for repairing ventricular wall rupture following mitral valve replacement [58]. In experimental models, the sealants have demonstrated efficacy for repairing acute aortic dissection [59], coronary artery anastomoses [60], inguinal hernia [61], pancreatic-jejunal anastomoses [62], and intestinal anastomoses [63], as well as for prevention of peritendinous adhesions following flexor tendon repair surgery [64]. However, despite desirable characteristics A second PEG-based sealant system is the PEG-PEG platform.…”

Section: Hydrogels For Wound Dressings and Wound Closurementioning

confidence: 99%

Hydrogel Materials

Holowka

Bhatia

2014

Drug Delivery

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In Chap. 2, we discussed the fundamental behavior behind the release of drug molecules from matrix species in response to degradation (i.e., chemical or enzymatic), erosion (i.e., surface or bulk), and swelling (i.e., crosslinks). In the case of swellable systems, we limited our focus only to the adjustment of swelling characteristics based on changing the crosslink density, polymer molecular weight between crosslinks, and hydrophilicity. These underlying features provide information regarding the pharmacokinetics of the system; however, they provide little indication of the physical requirements for actual therapeutic applications. For example, what if a swellable system reached a point within the human body where the matrix could not sustain its own structural integrity? What would be the consequences of the system breaking apart? Could we see premature drug release [1], an inflammatory response [2], or perhaps worse, the occlusion of an artery [3]? When we use swellable systems in physiological environments, care must be taken to understand the properties, both chemical and physical, to which it will be exposed throughout its life cycle within the body.In this chapter, we will discuss aqueous swellable systems classified as hydrogels [4], and their applications as implantable [5] and injectable [6] systems. Hydrogels are a species of crosslinked, hydrophilic, polymer molecules that absorb large amounts of water (≤99 %) to form a three-dimensional network. There is a broad application base for hydrogel materials, ranging from tissue engineering scaffolds [7] to breast implants [8] to contact lenses [9] (discussed in Chap. 2, Sect. 2.3). For the purposes of our current discussion, we will focus on implantable biosensors for diabetes treatment [10] and injectable hydrogels for cartilage repair [11]. We begin

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Tissue Adhesives for Repairing Inguinal Hernia: A Preliminary Study

Abstract: Our results suggest that laparoscopic injection of Db into the IHS is simple, safe, reliable, virtually scarless, and may be a reasonable alternative to standard open surgical inguinal hernia repair.

Cited by 28 publications

References 15 publications

A human case study demonstrating the safety and effectiveness of laparoscopic surgical glue injection hernioplasty for pediatric indirect inguinal hernia

A human case study demonstrating the safety and effectiveness of laparoscopic surgical glue injection hernioplasty for pediatric indirect inguinal hernia

Hernioplastia inguinal con malla sin tensión: Experiencia con adhesivo N-butil-cianoacrilato

Hydrogel Materials

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