Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

Yamagishi, Kazumasa; Koyanagi, Izumi; Takahashi, Isao; Amano, Hodaka; Takeoka, Shinji; Morimoto, Yuji; Fujie, Toshinori

doi:10.1038/s41551-018-0261-7

Cited by 159 publications

(128 citation statements)

References 32 publications

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“…A number of studies have reported the successful use of phototherapy, such as PTT and photodynamic therapy (PDT), in the treatment of cancers [41][42][43][44][45][46] . In our study, PTT only moderately delayed the tumor growth.…”

Section: Discussionmentioning

confidence: 99%

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

et al. 2020

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The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), as well as vascular and interstitial barriers. To overcome the abovementioned obstacles, we report a nano-pathogenoid (NPN) system that can in situ hitchhike circulating neutrophils and supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogenassociated molecular patterns of native bacteria, NPNs are effectively recognized and internalized by neutrophils. The neutrophils migrate towards inflamed tumors, extravasate across the blood vessels, and penetrate through the tumors. Then NPNs are rapidly released from neutrophils in response to inflammatory stimuli and subsequently taken up by tumor cells to exert anticancer effects. Strikingly, due to the excellent targeting efficacy, cisplatinloaded NPNs combined with PTT completely eradicate tumors in all treated mice. Such a nano-platform represents an efficient and generalizable strategy towards in situ cell hitchhiking as well as enhanced tumor targeted delivery.

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Section: Discussionmentioning

confidence: 99%

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

et al. 2020

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“…In the field of medical health, WPT has been employed by implanted wireless devices for monitoring gastrointestinal bleeding, [ 5 ] powering pacemakers, [ 6 ] or treatment of overactive bladder, [ 7 ] diabetes, [ 8 ] and cancer. [ 9 ] Without fragile cables, energy could be introduced into the body, achieving battery‐free working of implanted devices. At the same time, it could also solve the problem that light is hard to pass through the body due to the absorption by the tissues.…”

Section: Methodsmentioning

confidence: 99%

“…[ 16,17 ] Owing to the dense tissue structure of cancer, drug released from the implanted system is difficult to penetrate into the deep cancer, thus photosensitizers are introduced through injection for achieving photodynamic therapy (PDT) which is excited by the implanted light‐emitting diode (LED). [ 9,18 ] Among them, metronomic PDT (mPDT) which used weak and long‐term photoirradiation could reduce thermal effects that may cause thermal damage, while achieved safe PDT. Considering that low‐power devices could be implanted almost anywhere in the body, it is suitable for exciting photosensitizers for long‐term mPDT.…”

Section: Methodsmentioning

confidence: 99%

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Peng

et al. 2020

Advanced Materials

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Traditional phototherapies face the issue that the insufficient penetration of light means it is difficult to reach deep lesions, which greatly reduces the feasibility of cancer therapy. Here, an implantable nitric oxide (NO)‐release device is developed to achieve long‐term, long‐distance, remote‐controllable gas therapy for cancer. The device consists of a wirelessly powered light‐emitting diode (wLED) and S‐nitrosoglutathione encapsulated with poly(dimethylsiloxane) (PDMS), obtaining the NO‐release wLED (NO‐wLED). It is found that NO release from the NO‐wLED can be triggered by wireless charging and the concentration of produced NO reaches 0.43 × 10−6 m min−1, which can achieve a killing effect on cancer cells. In vivo anticancer experiments exhibit obvious inhibitory effect on the growth of orthotopic cancer when the implanted NO‐wLED is irradiated by wireless charging. In addition, recurrence of cancer can be prevented by NO produced from the NO‐wLED after surgery. By illumination in the body, this strategy overcomes the poor penetration and long‐wavelength dependence of traditional phototherapies, which also provides a promising approach for in vivo gas therapy remote‐controlled by wireless charging.

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“…As existing PDT uses optical fibers or a laser as optical sources, it must be injected into the body. Yamagishi et al proposed a metronomic PDT (mPDT) device based on a wireless‐powered ILED that can be inserted into the body . They implemented mPDT by attaching the LED device to the endothelium of the skin without inserting the optical source.…”

Section: Advanced Applications Of Smart Sensing Systems Based On Optomentioning

confidence: 99%

Smart Sensing Systems Using Wearable Optoelectronics

Hwang

et al. 2020

Advanced Intelligent Systems

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A wearable smart sensing system is capable of continuously monitoring biometric information such as respiration, pulse, and body temperature while attached to an arbitrary surface on the user's body to be utilized freely during activities. Research conducted on new materials, fabrication processes, structure of electrodes, and wireless communication technologies has made constant progress in the development of smart sensing systems that use entirely wearable forms of devices to go beyond conventional devices that are based on intrinsically rigid components, such as silicon. Among various platforms that can be used in the development of smart sensing systems, optoelectronics provides innovative sensing functions (e.g., human–machine interfaces and phototherapy) that can be transferred from traditional healthcare to smart healthcare, such as point of care. Optoelectronics are light‐mediated displays that allow a light source to be controlled and a large light spectrum to be detected. Recently, this platform that uses smart and wearable optoelectronic sensing systems has become increasingly advanced to better help human beings treat their diseases through self‐healthcare. Herein, recent advanced technologies in materials, structures, and wireless platforms for smart sensors using wearable optoelectronics are reviewed.

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Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

Cited by 159 publications

References 32 publications

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Smart Sensing Systems Using Wearable Optoelectronics

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