Tissue accumulation of DDT and its metabolites in the domestic fowl

Noakes, Diana N.; Benfield, C. A.

doi:10.1002/jsfa.2740161201

Cited by 27 publications

(3 citation statements)

References 4 publications

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“…It is known that o,p'-DDT accumulates to a much lesser extent than its para,para' isomer (Cummings et al, 1966). In the study of Noakes and Benfield (1965), only a few eggs at the beginning of the laying period were analyzed, so we cannot treat their data too seriously.…”

Section: Ddtmentioning

confidence: 99%

Accumulation of organochlorine pesticides in poultry: a review

Kan¹

1978

J. Agric. Food Chem.

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Accumulation ratios (level of pesticide in fat or egg to its level in the feed) of hexachlorobenzene (HCB),•, ß-, and 7-hexachlorocyclohexane (HCH), heptachlor and its epoxide, DDT, dieldrin, aldrin, endrin, and methoxychlor in laying hens and broilers are discussed. The pesticides can be grouped into several categories according to accumulation ratios: highly accumulating like HCB, d-HCH, heptachlor epoxide, dieldrin, aldrin; intermediate like heptachlor, endrin; low like a-and 7-HCH; and very low like methoxychlor. Depletion of residues of the pesticides in laying hens and eggs is correlated with the accumulative properties. Depletion of residues in broilers is mostly governed by growth rate and thus by dilution in the fat.

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Section: Ddtmentioning

confidence: 99%

Accumulation of organochlorine pesticides in poultry: a review

Kan¹

1978

J. Agric. Food Chem.

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“…Because of the stable and lipophilic nature of many organochlorines (Noakes & Benfield 1965;Ecobichon & Saschenbrecker 1968), they show both environmental persistence (Herman, Garrett & Rudd 1968;Dimond & Sherburne 1969) and 'biological magnification' (Hickey, Keith & Coon 1966). By these mechanisms many species of birds of prey have become highly contaminated with organochlorines.…”

Section: Introductionmentioning

confidence: 99%

DDE-Induced Eggshell-Thinning in the American Kestrel: A Comparison of the Field Situation and Laboratory Results

Lincer¹

1975

The Journal of Applied Ecology

116

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“…I,orsque le barbital est ad~ninistri par voie intraveineuse, le jeiine ne modifie pas la concentration sanguine du barbital, nlais il riduit neanmoins le temps d'induction au sommeil. I,a concentra- (usually 2.5, 5, and 10 min) .I from adipose tissue to other tissues (Dale et al 1962;Noakes and Benfield 1965;Wesley et al 1966Wesley et al , 1969Harvcy 1967;Donaldson et al 1968;Ecobichon and Saschenbrecker 1969;Brown 1970).…”

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Influence of Starvation on Absorption, Distribution, and Action of Barbital in Mice and Rats

Brodeur¹,

Lalonde²,

Leroux³

1974

Can. J. Physiol. Pharmacol.

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BROI,E~R, J., LALONDE, S.. and LEROUX, J. 1974. Influence of starvation on absorption, distribution, and action of barbital in mice and rats. Can. J. Physiol. Pharmacol. 52, 1192-1200 The influence of food deprivation on the disposition of barbital during the early phase following ~dministration of the drug was studied in mice and rats. Starvation consisted of withholding solid food, but not water, for 24-72 h in mice, and 72 h in rats. The results show that starvation leads to higher blood concentrations of barbital given intraperitoneally (i.p.1 and subcutaneously to mice and rats, apd intramuscularly to rats. This effect was observed 2.5-10 min following the injection of the barbiturate. In mice, starvation significantly reduced the interval between injection of the drug and loss of the righting reflex. but it extended the tluration of the sleeping period. When barbital was given intravenously, starvation no longer resulted in higher blood comncentrations of the drug, although starved mice went to sleep more rapidly than fed controls. At the moment of loss of the righting reflex. starved mice had significantly lower concentrations of barbital in the brain than fed controls. The total blood and plasma volumes of starved animals were tnoderately increased when expressed as a percentage of the body weight. These results suggest that starvation tnight influence the early phase of barbital absorption following its parenteral administration. There is also an indication that starvation could induce a state of hypersensitivity of the central nervous system to barbital. R R~D E U R , J., LALONDE, S. et I[,EROUX, J . 1974. Influence of starvation on absorption, distribution, and action of barbital in mice and rats. Can. J. Physiol. Pharmacol. 52, 1192-1200. Nous avons CtridiC l'influence d'une ptriode de jeiine aigri sur le sort metabolique du barbital au cours des quelques minutes qui suivent son administration. chez In souris et le rat. Nous avons enlev6 toute nourriture solidc, rr~ais norm l'eau de brenvage, pendant tine pkriode de 24 L 72 h chez la souris, et pendant une pCriode de 72 h c h e~ Ie rat.Ides r6sultats obtenus nlontrent que le jeijne entraine une augmentation de la concentration sanguine du barbital administrt par voie intrap6ritonCale et sous-cutanke, chez la souris et le rat, ainsi que de celle du barbital adtninistrC par voie intrn-musculaire, chez 1e rat. Get effet s'observe au cours des qtlelques 2.5 & 10 nlin qui suivent I'injection du barbital. Chez la souris, le jeiine rCduit le temps d'induction au somnmeil, suite & l'administration du barbital. rnais prolonge la durCe totale du somrneil. I,orsque le barbital est ad~ninistri par voie intraveineuse, le jeiine ne modifie pas la concentration sanguine du barbital, nlais il riduit neanmoins le temps d'induction au sommeil. I,a concentration cCrCbrale du barbituriqrie est abaissCe chez les souris i jeun par rapport aux souris contrbles, au moment ou les animaux s'endorment. Enfin, le jei~ne entraine une augmentation relative des volun~es sanguin et...

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Tissue accumulation of DDT and its metabolites in the domestic fowl

Cited by 27 publications

References 4 publications

Accumulation of organochlorine pesticides in poultry: a review

Accumulation of organochlorine pesticides in poultry: a review

DDE-Induced Eggshell-Thinning in the American Kestrel: A Comparison of the Field Situation and Laboratory Results

Influence of Starvation on Absorption, Distribution, and Action of Barbital in Mice and Rats

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