Tirbanibulin and solar lentigo clearance: an aesthetically pleasing side effect?

Abstract

Tirbanibulin and solar lentigo clearance: an aesthetically pleasing side effect? Dear Editor, Tirbanibulin is a novel topical agent for the treatment of actinic keratosis (AK). 1 It inhibits tubulin polymerization and Src kinase signaling. 1 The simple way of administration and limited range of adverse events make it a suitable option for patients. 1

Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience

“…Moving to the anti-aging effects, to date, only a case report has recently been reported about the efficacy of tirbanibulin ointment in a 78-year-old man with multiple flat, erythematous, scaly lesions on the scalp, with solar lentigos the field of cancerization as well [ 15 ]. After 2 months, clearance of AKs and solar lentigo was detected in the field of application.…”

“…However, although these effects are documented for some AK therapies, they have not yet been explored with the topical application of tirbanibulin 1% ointment. While data about its efficacy and safety profile are already available [ 11 – 14 ], its impact on photodamage, usually associated with AKs in the context of field cancerization, has recently been reported only in a recent case report [ 15 ]. On this topic, we report a retrospective case series of patients affected by AKs on the face and scalp treated with tirbanibulin 1% in which the topical treatment caused a striking amelioration of concomitant photodamage, with improvement of both wrinkles and solar lentigo.…”