TIR signal promotes interactions between lipase-like proteins and ADR1-L1 receptor and ADR1-L1 oligomerization

Z, Wu; Tian, Lei; Liu, Xueru; Zhang, Yuelin; Li, Xin

doi:10.1093/plphys/kiab305

Cited by 58 publications

(59 citation statements)

References 16 publications

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“…It has become increasingly evident that in angiosperms, the EDS1 family has evolved to function cooperatively with helper RNLs, by forming distinct signalling modules of EDS1:PAD4:ADR1 and EDS1:SAG101:NRG1 (Lapin et al 2019 ; Wu et al 2019 , 2021 ; Sun et al 2021 ). This view is indirectly supported by phylogenetic observations of co-occurrence of ADR1 and PAD4 and NRG1 and SAG101 orthologs in specific lineages.…”

Section: Downstream Pathways—the Eds1 Family and Helper Rnls Control ...mentioning

confidence: 99%

“…For instance, NRG1 and SAG101 orthologs are present in most angiosperms except Caryophyllales and monocots, and both families are absent in gymnosperms (Collier et al 2011 ; Lapin et al 2019 ). The Arabidopsis pad4 single and adr1 triple mutants are similarly more susceptible to pathogens, compared to wild-type plants, and their phenotype is similar in combined knockouts of pad4 and adr1s (Sun et al 2021 ; Wu et al 2021 ), suggesting that these two components operate in the same pathway. Similarly, sag101 nrg1 triple mutants phenocopy sag101 single or nrg1 double mutants, displaying enhanced susceptibility upon activation of the TNL pair RPS4:RRS1 in Arabidopsis (Sun et al 2021 ; Wu et al 2021 ).…”

Section: Downstream Pathways—the Eds1 Family and Helper Rnls Control ...mentioning

confidence: 99%

“…The Arabidopsis pad4 single and adr1 triple mutants are similarly more susceptible to pathogens, compared to wild-type plants, and their phenotype is similar in combined knockouts of pad4 and adr1s (Sun et al 2021 ; Wu et al 2021 ), suggesting that these two components operate in the same pathway. Similarly, sag101 nrg1 triple mutants phenocopy sag101 single or nrg1 double mutants, displaying enhanced susceptibility upon activation of the TNL pair RPS4:RRS1 in Arabidopsis (Sun et al 2021 ; Wu et al 2021 ). Exchanging components of the EDS1:RNL combinations or knockout of all RNLs result in further increased susceptibility to pathogens (Sun et al 2021 ; Wu et al 2021 ).…”

Section: Downstream Pathways—the Eds1 Family and Helper Rnls Control ...mentioning

confidence: 99%

“…Similarly, sag101 nrg1 triple mutants phenocopy sag101 single or nrg1 double mutants, displaying enhanced susceptibility upon activation of the TNL pair RPS4:RRS1 in Arabidopsis (Sun et al 2021 ; Wu et al 2021 ). Exchanging components of the EDS1:RNL combinations or knockout of all RNLs result in further increased susceptibility to pathogens (Sun et al 2021 ; Wu et al 2021 ). These results suggest that the integrity of each intact module is required; the two branches can operate in parallel pathways, differentially contributing to common functions; and they may also have compensatory functions when either module is missing.…”

Section: Downstream Pathways—the Eds1 Family and Helper Rnls Control ...mentioning

confidence: 99%

“…In addition, gymnosperms and angiosperms have acquired lipase-like proteins that belong to the EDS1 (enhanced disease susceptibility 1) family, which are involved in a broad range of plant innate immune responses (Lapin et al 2020 ). Recent studies suggest that the EDS1 family members likely relay signals from activated sensor NLRs to helper NLRs (Sun et al 2021 ; Wu et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Structural basis of NLR activation and innate immune signalling in plants

et al. 2022

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Animals and plants have NLRs (nucleotide-binding leucine-rich repeat receptors) that recognize the presence of pathogens and initiate innate immune responses. In plants, there are three types of NLRs distinguished by their N-terminal domain: the CC (coiled-coil) domain NLRs, the TIR (Toll/interleukin-1 receptor) domain NLRs and the RPW8 (resistance to powdery mildew 8)-like coiled-coil domain NLRs. CC-NLRs (CNLs) and TIR-NLRs (TNLs) generally act as sensors of effectors secreted by pathogens, while RPW8-NLRs (RNLs) signal downstream of many sensor NLRs and are called helper NLRs. Recent studies have revealed three dimensional structures of a CNL (ZAR1) including its inactive, intermediate and active oligomeric state, as well as TNLs (RPP1 and ROQ1) in their active oligomeric states. Furthermore, accumulating evidence suggests that members of the family of lipase-like EDS1 (enhanced disease susceptibility 1) proteins, which are uniquely found in seed plants, play a key role in providing a link between sensor NLRs and helper NLRs during innate immune responses. Here, we summarize the implications of the plant NLR structures that provide insights into distinct mechanisms of action by the different sensor NLRs and discuss plant NLR-mediated innate immune signalling pathways involving the EDS1 family proteins and RNLs.

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Section: Downstream Pathways—the Eds1 Family and Helper Rnls Control ...mentioning

confidence: 99%

Section: Downstream Pathways—the Eds1 Family and Helper Rnls Control ...mentioning

confidence: 99%

Section: Downstream Pathways—the Eds1 Family and Helper Rnls Control ...mentioning

confidence: 99%

Section: Downstream Pathways—the Eds1 Family and Helper Rnls Control ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Structural basis of NLR activation and innate immune signalling in plants

et al. 2022

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Research on ADR1s helps understanding the plant immune network

Zhou

2022

Stress Biology

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Plant innate immunity begins with the recognition of pathogens by plasma membrane localized pattern-recognition receptors (PRRs) and intracellular nucleotide-binding domain leucine-rich repeat containing receptors (NLRs), which lead to pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), respectively. For a long time, PTI and ETI have been regarded as two independent processes although they share multiple components and signal outputs. Increasing evidence shows an intimate link between PTI and ETI. PTI and ETI mutually potentiate each other, and this is essential for robust disease resistance during pathogen infection. An ancient class of NLRs called RNLs, so named because they carry a Resistance to Powdery Mildew 8 (RPW8)-like coiled-coil (CC) domain in the N terminus, has emerged as a key node connecting PTI and ETI. RNLs not only act as helper NLRs that signal downstream of sensor NLRs, they also directly mediate PTI signaling by associating with PRR complexes. Here, we focus on Activated Disease Resistance 1 (ADR1), a subclass of RNLs, and discuss its role and mechanism in plant immunity.

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