TIP120B: A Novel TIP120-Family Protein That Is Expressed Specifically in Muscle Tissues

Aoki, Tsutomu; Okada, Nami; Ishida, Michiko; Yogosawa, Shingo; Makino, Yasutaka; Tamura, Tomohiro

doi:10.1006/bbrc.1999.1147

Cited by 34 publications

(43 citation statements)

References 16 publications

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“…Although FAF-X might be expected to bind to the Ub moiety of the Ub-UbcH5A fusion protein, we think it more likely that FAF-X bound to another protein in the eluate, because we eliminated proteins with high affinity for Ub early in the purification (see "Experimental Procedures"). TIP120B is a putative transcriptional regulator that interacts with TATA-binding protein (38); TIP120A, a closely related protein, has been detected in a complex that contains several proteasomal ATPases (39). Peptides from both TIP120 proteins were present in the band marked TIP120 in Fig.…”

Section: Fig 3 E3 Affinity Purification Using Linear Ub-ubch5a Fusimentioning

confidence: 92%

A HECT Domain E3 Enzyme Assembles Novel Polyubiquitin Chains

You

Pickart

2001

Journal of Biological Chemistry

123

128

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Section: Fig 3 E3 Affinity Purification Using Linear Ub-ubch5a Fusimentioning

confidence: 92%

A HECT Domain E3 Enzyme Assembles Novel Polyubiquitin Chains

You

Pickart

2001

Journal of Biological Chemistry

123

128

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“…Because TIP120A is a major cullin binding protein, we renamed it CANDl for cullin-associated neddS-dissociated protein 1 (see below). We have also noticed the existence of a TIP120A homolog, TIP120B, in the EST and the GenBank databases (Aoki et al, 1999). The close homology between T1P120A and B suggests that T1P120B might also be a cullin binding protein.…”

Section: Resultsmentioning

confidence: 75%

Use p27(KIPI) Degradation for Breast Cancer Diagnosis and Therapy

Zhang¹

2003

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“…Specifically, CAND2 is believed to be induced during embryogenesis and is localized only in muscle, whereas TIP120A has ubiquitous expression [1]. Also, CAND2 is a transcription factor that regulates myogenesis by suppressing the ubiquitination of myogenin.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of CAND2 and WNT7a as Candidate Genes for Congenital Idiopathic Clubfoot

Shyy

Dietz

Dobbs³

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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Congenital idiopathic clubfoot is a common pediatric musculoskeletal deformity with no known etiology. The deformity reportedly follows a Mendelian pattern of inheritance. Recent work has demonstrated linkage in chromosome 3 and 13 in a large, multigeneration, highly penetrant family with idiopathic clubfoot. From the linkage region on chromosome 3, we selected the candidate genes CAND2 and WNT7a, which are involved in lower extremity development, and hypothesized mutations in these genes would be associated with the phenotype of congenital idiopathic clubfoot. The CAND2 gene was sequenced in 256 clubfoot patients, and 75 control patients, while WNT7a was screened using 56 clubfoot patients and 50 control patients. We found a polymorphism in each gene, but the single nucleotide change in CAND2 was a silent mutation that did not alter the amino acid product, and the single nucleotide change in WNT7a was in the upstream, non-coding or promoter region before the start codon. Based on these results it is unlikely CAND2 and WNT7a are the major genes that causes clubfoot, however WNT7a might be one of many genes that could increase susceptibility to develop clubfoot but do not directly cause it.

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TIP120B: A Novel TIP120-Family Protein That Is Expressed Specifically in Muscle Tissues

Cited by 34 publications

References 16 publications

A HECT Domain E3 Enzyme Assembles Novel Polyubiquitin Chains

A HECT Domain E3 Enzyme Assembles Novel Polyubiquitin Chains

Use p27(KIPI) Degradation for Breast Cancer Diagnosis and Therapy

Evaluation of CAND2 and WNT7a as Candidate Genes for Congenital Idiopathic Clubfoot

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