Tip110, the Human Immunodeficiency Virus Type 1 (HIV-1) Tat-interacting Protein of 110 kDa as a Negative Regulator of Androgen Receptor (AR) Transcriptional Activation

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

“…[14][15][16][17] We demonstrated previously that TIP110 regulates the transcription of HIV-1 and cellular genes. 18,19 It is considered a mammalian homolog of the yeast Prp24 protein, and functions as a general pre-mRNA splicing factor. 20 Using molecular, cellular, and genetic strategies, including TIP110 transgenic (TIP110 TG ) and conditional knockout (TIP110 ϩ/Ϫ ) mice, ectopic expression, and shRNA knockdown, we found that TIP110 regulates HPC/HSC function, effects likely involving cell-cycle regulation, reciprocal control of the expression of TIP110 and CMYC, and GATA2 control of TIP110 expression.…”

Role of Tat-interacting protein of 110 kDa and microRNAs in the regulation of hematopoiesis

“…It was also later called squamous cell carcinoma antigen recognized by T cells 3 (SART3), as it was found to encode tumor epitopes that were capable of inducing cytotoxic T lymphocytes [3], or called p110/p110 nrb for its RNA-binding activity [4,5]. We have shown that Tip110 mRNA is expressed in human tissues including the brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, and peripheral blood lymphocytes [6]. We and several other groups have also found that Tip110 protein is expressed in many different cancer cell lines and tissues at a much higher level than normal cells and tissues [3,[7][8][9][10].…”

“…Analysis of Tip110 sequence using the Simple Modular Architecture Research Tool reveals several structural motifs from the N terminus to the C terminus: seven half-a-tetratricopeptide repeats in its N terminus, two RNA-recognition motifs, a nuclear localization signal, and an LXXLL motif [6]. Several Tip110 functions were initially inferred from these structural motifs.…”

Tip110 Protein Binds to Unphosphorylated RNA Polymerase II and Promotes Its Phosphorylation and HIV-1 Long Terminal Repeat Transcription

“…Human Tip110 was found to encode a tumor rejection antigen in various cancers; it is expressed in a number of cancer cell lines as well as the majority of cancer tissues (28 -30). In addition, Tip110 also binds to the androgen receptor through the nuclear receptor box and functions as a repressor of androgen receptor transcription activation through interference with the complex formation between the androgen receptor and androgen receptor-responsive element (31).…”