Tip of the iceberg: Emergence of Langya virus in the postpandemic world

Taseen, Shafaq; Abbas, Munib; Nasir, Filza; Amjad, Syeda Wania; Asghar, Muhammad Sohaib

doi:10.1002/jmv.28173

Cited by 6 publications

(12 citation statements)

References 12 publications

(35 reference statements)

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“…-Main entry is oronasal 17 -No strong evidence on human to human transmission 10,20 -Genetic mutation may increase human to human transmissibility 10,21 Pathophysiology -Viral entry receptor for Henipavirus are Ephrin B2 (arteries, arterioles, and capillaries in multiple organs and tissues) and B3 (nervous system predominant)…”

Section: Criteria Layv Characteristicsmentioning

confidence: 99%

A comprehensive review of Langya virus and framework for future zoonotic disease control

Thien,

Tran,

Uyen

et al. 2024

Reviews in Medical Virology

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First reported in August 2022, the Langya virus (LayV) has emerged as a potential global health threat in the post‐COVID‐19 era. Preliminary reports show that 35 patients near Shandong and Henan, China experienced a febrile acute LayV infection. We conducted this review following the PRISMA protocol to synthesise current knowledge on LayV's characteristics in terms of molecular, clinical, and public health perspectives. This virus belongs to the Paramyxoviridae family and carries a non‐segmented, single‐stranded negative‐sense RNA genome. Shrews may be the natural reservoir of the virus. Clinical symptoms range from mild flu‐like symptoms to severe manifestations involving pneumonia, haematological disorders, and organ dysfunction. Diagnostic methods include PCR and ELISA assays. Despite the absence of established treatments, antiviral drugs such as ribavirin and chloroquine may be useful in some cases. In light of prevention, a comprehensive approach that emphasises multidisciplinary collaboration is crucial for early surveillance and response. Urgent global efforts are needed for vaccine development and preparedness against this potential pandemic threat. As the viral dynamics remain uncertain, a proactive approach is vital to mitigate the impact of not only LayV but also future threats on a large scale in long term.

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Section: Criteria Layv Characteristicsmentioning

confidence: 99%

A comprehensive review of Langya virus and framework for future zoonotic disease control

Thien,

Tran,

Uyen

et al. 2024

Reviews in Medical Virology

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show abstract

“…The scarcity of adequate information and low number of cases detected till date indicate that presently there is no need to fear a worldwide health crisis or a pandemic caused by LayV, however proactive measures are required to be adopted after judging that we are not sitting at the edge of any iceberg, therefore need to be ready to counter any feasible future threat and / possible pandemic potential [11][12][13][14][15]. Strengthening of diagnostic facilities and surveillance activities are essential for monitoring the newer infections and risks of spread of LayV.…”

Section: Prevention and Control Measuresmentioning

confidence: 99%

“…Explorative researches are required to investigate any severity of LayV infection, the means of transmission, and the appraisal of the virus's feasible overall spread in China and the world as a whole [11][12][13][14][15]. Infectious disease researchers have been sounding the alarm for a while now about the potential for zoonotic virus spillovers due to the climate catastrophe and the reckless destruction of natural resources.…”

Section: Prevention and Control Measuresmentioning

confidence: 99%

“…Almost three years after the identification of the novel SARS-CoV-2 virus in China, a new zoonotic virus has been found in the Shandong and Henan provinces, with 35 cases identified so far [6]. This novel phylogenetically distinct Henipavirus strain is known as the Langya Henipavirus or the LayV, and various aspects of this virus and the disease it causes, zoonotic public health concerns and whether it is a virus sitting on tip of the iceberg for causing any major public health concerns need to be investigated with further explorative researches and disease surveillance findings [7][8][9][10][11][12][13][14][15]. There are several Henipaviruses already identified among them Hendra virus and Nipah virus are two of the already known henipaviruses; the other kinds include cedar virus, mojiang virus, and the ghanaian bat virus, which are all considerably less virulent.…”

Section: Introductionmentioning

confidence: 99%

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‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update

Sah¹,

Shah²,

Rao³

et al. 2023

Preprint

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The risk of 'zoonotic spillovers,' or the transmission of viruses from animals to humans, has been raised by climate change and the devastation of nature, as infectious disease experts have long warned. Even as the world works to stop the spread of the currently unfolding pandemic of coronavirus disease 2019 (COVID-19) and the breakout of monkeypox virus (MPXV), a new animal virus, the Langya henipavirus (LayV), has been discovered in humans in Eastern China. The scientists say there is little danger of the virus spreading among humans, but it shares genetic material with Hendra virus and Nipah virus, two other henipaviruses that infect humans and cause life-threatening respiratory diseases. Humans infected with LayV can expect to experience high body temperature, cough, weariness, poor appetite, muscle discomfort, myalgia, nausea and vomiting. It is likely that the virus will spread from animals to humans. Currently, the health authorities of Taiwan and other health organizations are tracking the progress of the ailment to ensure it does not reach humans. Researchers have examined 25 species of small wild animals for presence of the virus, and so far, shrews are the only ones that have tested positive for the virus's RNA. Based on these results, shrews are a possible candidate for the virus's natural reservoir. Too far, no therapies or vaccines have been developed and licensed for henipaviruses like the LayV. When other therapies fail to alleviate viral infections, ribavirin may be the next best thing. The need for novel vaccinations against the LayV infection and the timely delivery of these vaccines to areas at high epidemiological risk is real. To lessen the likelihood of a health calamity being caused by this newly developing virus, it is crucial to conduct active surveillance in a transparent and globally collaborative manner. The questions that have not been answered yet require additional study.

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“…It is, therefore, vital to focus on this epidemic and prevent the virus from spreading. Other than some reports of the activity of ribavirin and favipiravir on the Nipah virus, there are no approved drugs or vaccines for Henipaviruses [ 14 ]. There are no effective treatments for LayV.…”

mentioning

confidence: 99%

Is the emergence of the zoonotic Langya virus amidst COVID-19 and monkeypox a cause for concern?

et al. 2023

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Tip of the iceberg: Emergence of Langya virus in the postpandemic world

Abstract: Recently, a new animal virus with the potential to infect humans has been discovered in eastern China, known as Langya henipavirus (LayV). 1 This Henipavirus belongs to the Paramyxovirus family containing enveloped, single-stranded RNA. Among five identified

Cited by 6 publications

References 12 publications

A comprehensive review of Langya virus and framework for future zoonotic disease control

A comprehensive review of Langya virus and framework for future zoonotic disease control

‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update

Is the emergence of the zoonotic Langya virus amidst COVID-19 and monkeypox a cause for concern?

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