Tip enhanced Raman spectroscopy imaging of opaque samples in organic liquid

Touzalin, Thomas; Dauphin, Alice L.; Joiret, S.; Lucas, Ivan T.; Maisonhaute, Emmanuel

doi:10.1039/c6cp02596j

Cited by 42 publications

(42 citation statements)

References 33 publications

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“…TERS in liquid environments was first demonstrated in 2009 using silver-coated AFM probes, with self-assembled molecular monolayers used to protect the tips from contamination [130]. Further applications of liquid TERS have since been demonstrated, including the analysis of lipid bilayers [131], the adsorption of probe molecules on Au(111) [132], and TERS imaging in organic liquids [133]. It has taken several years since the first demonstration of liquid TERS to develop EC-TERS but 2015 saw major advances from two independent groups [134,135].…”

Section: Ec-tersmentioning

confidence: 99%

Advances in surface-enhanced vibrational spectroscopy at electrochemical interfaces

Wain

O’Connell

2017

Advances in Physics: X

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Electrochemical interfaces are ubiquitous, and characterisation tools that allow us to interrogate them on the molecular scale underpin a wide range of technologies. Because of their dynamic nature, in situ or operando measurement is often necessary, and the coupling of electrochemical techniques with spectroscopic methods is a powerful solution to this challenge. Vibrational spectroscopy in particular can provide important insights into the chemical nature of species adsorbed at electrode surfaces. When combined with electrochemistry, the influence of a potential perturbation to the interface can be studied, helping to build a complete picture of molecular processes in complex electrochemical systems. Here, we review the latest advances in vibrational spectroscopy at electrochemical interfaces, with a focus on surfaceenhanced approaches including surface-enhanced Raman scattering, shell-isolated nanoparticle-enhanced Raman spectroscopy, tip-enhanced Raman spectroscopy and surface-enhanced infrared absorption spectroscopy.

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Section: Ec-tersmentioning

confidence: 99%

Advances in surface-enhanced vibrational spectroscopy at electrochemical interfaces

Wain

O’Connell

2017

Advances in Physics: X

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“…In addition, STM-TERS can also be manipulated in liquid. A few studies have been carried out by electrochemical STM-TERS (EC-TERS) [ 53 , 54 , 55 , 56 ], where the STM probe was immersed in some suitable solvent for the electrochemical measurement. In EC-TERS, a suitable liquid is primarily required to maintain the tunneling current, and meanwhile a proper coating on the tip should be satisfied to ensure that the Faradaic current doesn’t interfere with the tunneling current.…”

Section: Tip Enhanced Raman Spectroscopy (Ters) Experimentsmentioning

confidence: 99%

Atomic Force Microscopy Based Tip-Enhanced Raman Spectroscopy in Biology

Gao

Zhao

et al. 2018

IJMS

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Most biological phenomena occur at the nanometer scale, which is not accessible by the conventional optical techniques because of the optical diffraction limitation. Tip-enhanced Raman spectroscopy (TERS), one of the burgeoning probing techniques, not only can provide the topography characterization with high resolution, but also can deliver the chemical or molecular information of a sample beyond the optical diffraction limitation. Therefore, it has been widely used in various structural analyses pertaining to materials science, tissue engineering, biological processes and so on. Based on the different feedback mechanisms, TERS can be classified into three types: atomic force microscopy based TERS system (AFM-TERS), scanning tunneling microscopy based TERS system (STM-TERS) and shear force microscopy based TERS system (SFM-TERS). Among them, AFM-TERS is the most widely adopted feedback system by live biosamples because it can work in liquid and this allows the investigation of biological molecules under native conditions. In this review, we mainly focus on the applications of AFM-TERS in three biological systems: nucleic acids, proteins and pathogens. From the TERS characterization to the data analysis, this review demonstrates that AFM-TERS has great potential applications to visually characterizing the biomolecular structure and crucially detecting more nano-chemical information of biological systems.

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“…Emerging applications of TERS using a liquid medium [180][181][182] and improvements in the data acquisition speed by Van Duyne et al 183 will make this technique a promising tool for imaging structural and dynamic events in live cell membranes. Therefore the sample preparation is easier, and the potential of altering the membrane structure and dynamics during the imaging process is limited.…”

Section: Figurementioning

confidence: 99%

Optical Imaging of the Nanoscale Structure and Dynamics of Biological Membranes

2018

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Biological membranes serve as the fundamental unit of life, allowing the compartmentalization of cellular contents into subunits with specific functions. The bilayer structure, consisting of lipids, proteins, small molecules, and sugars, also serves many other complex functions in addition to maintaining the relative stability of the inner compartments. Signal transduction, regulation of solute exchange, active transport, and energy transduction through ion gradients all take place at biological membranes, primarily with the assistance of membrane proteins. For these functions, membrane structure is often critical. The fluidmosaic model introduced by Singer and Nicolson in 1972 evokes the dynamic and fluid nature of biological membranes.(1) According to this model, integral and peripheral proteins are oriented in a viscous phospholipid bilayer. Both proteins and lipids can diffuse laterally through the two-dimensional structure. Modern experimental evidence has shown, however, that the structure of the membrane is considerably more complex; various domains in the biological membranes, such as lipid rafts and confinement regions, form a more complicated molecular organization. The proper organization and dynamics of the membrane components are critical for the function of the entire cell. For example, cell signaling is often initiated at biological membranes and requires receptors to diffuse and assemble into complexes and clusters, and the resulting downstream events have consequences throughout the cell. Revealing the molecular level details of these signaling events is the foundation to understanding numerous unsolved questions regarding cellular life.

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Tip enhanced Raman spectroscopy imaging of opaque samples in organic liquid

Cited by 42 publications

References 33 publications

Advances in surface-enhanced vibrational spectroscopy at electrochemical interfaces

Advances in surface-enhanced vibrational spectroscopy at electrochemical interfaces

Atomic Force Microscopy Based Tip-Enhanced Raman Spectroscopy in Biology

Optical Imaging of the Nanoscale Structure and Dynamics of Biological Membranes

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