Tiotropium/Olodaterol Improves Pulmonary Function and Physical Activity in Patients with Treatment-Naïve COPD

Takahashi, Koichiro; Uchida, Masataka; Kato, Go; Takamori, Ayako; Sadamatsu, Hironori; Tanaka, Masahide; Tajiri, Ryo; Inoue, Hiroshi; Kinoshita, Takashi; Kojima, Kensuke; Yoshida, Makoto; Kobayashi, Hiromi; Tashiro, Hiroki; Hayashi, Shinichiro; Kawaguchi, Atsushı; Sueoka‐Aragane, Naoko; Kawayama, Tomotaka

doi:10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2552

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“…Clinical trials have demonstrated that tiotropium/ olodaterol improves breathlessness 56,57 (including during exercise tests 58 ), lung hyperinflation 59 and inspiratory capacity 58,60 compared with its monocomponents, and activity-related breathlessness and breathing discomfort versus placebo 60 . This combination has also been shown to increase exercise capacity during walking and cycling tests 60,61 versus placebo and improve physical activity in treatment-naive patients, as indicated by reductions in breathlessness and in the amount of time spent in a sedentary position 59,[62][63][64][65] . Notably, in a multicentre, multinational clinical trial, improvements from baseline in exercise endurance time for both cycling (19%) and walking (20%) were observed in patients with COPD following 6 weeks of treatment with tiotropium/olodaterol 66 .…”

Section: The Role Of Bronchodilators On Physical Activity In Copd: Re...mentioning

confidence: 99%

Targeting exertional breathlessness to improve physical activity: the role of primary care

Román-Rodríguez

Kocks

2021

npj Prim. Care Respir. Med.

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Primary care physicians (PCPs) play a crucial role in the diagnosis and management of chronic obstructive pulmonary disease (COPD). By working together with patients to target exertional breathlessness and increase physical activity, PCPs have an important role to play, early in the disease course, in improving patient outcomes in both the short and long term. In this article, we consider how physical activity affects disease progression from the PCP perspective. We discuss the role of pharmacological therapy, the importance of an holistic approach and the role of PCPs in assessing and promoting physical activity. The complexity and heterogeneity of COPD make it a challenging disease to treat. Patients’ avoidance of activity, and subsequent decline in capacity to perform it, further impacts the management of the disease. Improving patient tolerance of physical activity, increasing participation in daily activities and helping patients to remain active are clear goals of COPD management. These may require an holistic approach to management, including pulmonary rehabilitation and psychological programmes in parallel with bronchodilation therapy, in order to address both physiological and behavioural factors. PCPs have an important role to optimise therapy, set goals and communicate the importance of maintaining physical activity to their patients. In addition, optimal treatment that addresses activity-related breathlessness can help prevent the downward spiral of inactivity and get patients moving again, to improve their overall health and long-term prognosis.

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Section: The Role Of Bronchodilators On Physical Activity In Copd: Re...mentioning

confidence: 99%

Targeting exertional breathlessness to improve physical activity: the role of primary care

Román-Rodríguez

Kocks

2021

npj Prim. Care Respir. Med.

View full text Add to dashboard Cite

show abstract

Tiotropium/Olodaterol Improves Pulmonary Function and Physical Activity in Patients with Treatment-Naïve COPD

Abstract: Saga naive COPD physical activity evaluation (SCOPE) study investigator group;

Cited by 1 publication

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Targeting exertional breathlessness to improve physical activity: the role of primary care

Targeting exertional breathlessness to improve physical activity: the role of primary care

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